宁波市鄞州区孕妇<span>HBV感染现状及HBV宫内感染相关危险因素调查研究</span>

doi:10.3969/j.issn.1006-5253.2019.0４.024

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Abstract Objective To explore the status quo of HBV infection in pregnant women in Yinzhou District of Ningbo City and related risk factors of HBV intrauterine infection, and provide reference for clinical HBV prevention.Methods Questionnaire analysis was conducted on 1 100 pregnant women who first established health cards in the hospital, simultaneously chemiluminescence was used to detect serum hepatitis B markers in pregnant women. According to the results, 182 pregnant women with hepatitis B surface antigen (HBsAg) positive were followed up until the pregnant woman gave birth, and the placental tissue and cord blood of pregnant women during childbirth were collected. The umbilical cord blood HBsAg was detected with enzyme linked immunosorbent assay (ELISA), the blood and blood HBV-DNA of pregnant women was detected with realtime PCR, and the HBsAg of the placenta tissue was detected with immunohistochemistry. Unconditional logistic regression analysis and ^χ2test were used to analyze the influence factors of HBV intrauterine infection.Results Among the 1 100 pregnant women, 182 pregnant women were found to be HBsAg positive, and the HBV infection rate was 16.55%. Through cord blood test, a total of 36 HBV intrauterine infections occurred in 182 pregnant women, and the HBV infection rate was 19.78%. The survey results showed that The main risk factors for HBV intrauterine infection in pregnant women included prepregnancy overweight, placental HBsAg positive, and maternal serum hepatitis B E antigen (HBeAg) positive (OR=3.377, 5.155, 4.651, P<0.05).Conclusion For obese pregnant women with HBsAg and HbeAg positive, the incidence of HBV intrauterine infection is large, so they must be given high priority, and they need to improve their own protection awareness, strengthen preventive measures, so as to avoid the risk of infection.

Key words： pregnant woman HBV infection HBV intrauterine infection risk factor investigation

Received: 16 November 2018

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	Articles by authors
	Zeng Xiaoyi
	He Xiaoling
	Xu Lili
	Huang Mengjia

Cite this article:

Zeng Xiaoyi,He Xiaoling,Xu Lili, et al. Investigation on HBV infection status of pregnant women and risk factors of HBV intrauterine infection in Yinzhou District of Ningbo City[J]. journal1, 2019, 26(4): 319-320.

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http://manu58.magtech.com.cn/Jwk_zgyytj/EN/10.3969/j.issn.1006-5253.2019.0４.024 OR http://manu58.magtech.com.cn/Jwk_zgyytj/EN/Y2019/V26/I4/319

［1］刘晶华，蒋佩茹.围产期乙型肝炎病毒母婴垂直传播的防治［J/CD］.中华产科急救电子杂志，2017，6(3):175-179.

［2］世界卫生组织.慢性乙型肝炎病毒感染预防、关怀和治疗指南［J］.中国病毒病杂志，2015，17(5):342-346.

［3］杨松静，黄桢翔，陈碧钦，等.孕妇乙型肝炎病毒宫内感染相关危险因素研究［J］.中华疾病控制杂志，2017，21(1):44-47.

［4］ZHANG WL，JI ZH，WANG L，et al.The prevalence of hepatitis B virus infection in China is decreasing:A metaanalysis on HBsAgpositive rate among general Chinese populations aged 159 years［J］.Infectious Diseases，2015，47(12):878-888.

［5］黄睿，曹引丽，高洁，等.西安市HBV宫内感染的发生情况及其影响因素研究［J］.华南预防医学，2017，43（6）:507-511.

［6］JARCUSKA P,JANICKO M, KRUZLIAK P, et al.Hepatitis B virus infection in patientswith metabolic syndrome:a complicated relationship. Results of a population based study［J］. Eur J Intern Med，2014，25(3):286-291.

［7］许艳丽，刘华放，康晓迪，等.代谢综合征对慢性HBV感染孕妇母婴结局的影响［J/CD］.中华实验和临床感染病杂志（电子版）,2016，10(4):396-401.

［8］包依夏姆·阿巴拜克力, 努力比亚·阿不杜克尤木,张跃新.乙肝疫苗联合HBIG接种阻断HBsAg/HBeAg双阳性孕妇HBV母婴传播的效果研究［J］.实用肝脏病杂志，2017，20（2）:248-249.

［9］庞琳，王彩英，何明，等.HBsAg阳性母亲其婴幼儿免疫阻断后无/低应答危险因素及个体化免疫干预效果分析［J/CD］.中华实验和临床感染病杂志（电子版）, 2017，11(5):508-512.

［10］赵燕青，顾梅蕾，张媛媛，等. HBsAg阳性孕妇胎盘组织HBV感染相关因素分析［J/CD］.中华实验和临床感染病杂志（电子版），2015，9(3):393-396.

［11］王璐，代晶芳，张国梅.HBV高病毒载量孕妇与新生儿宫内感染的相关性分析［J］.中华医院感染学杂志，2018，28（4）:586-589.