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| Nested casecontrol study on risk factors of acute kidney injury of critically ill patients |
| Li Xiuyuan1, Gao Jinxia2, Zhang Zenglei1, Lü Hengjuan1, Song Qiuying1, Li Qiang1, Ye Hongting2 |
1 .Hongqi Hospital, Mudanjiang Medical College, Mudanjiang 157011, China;
2 .School of Public Health, Mudanjiang Medical College |
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Abstract Objective To explore the risk factors of acute kidney injury (AKI) in critically ill patients.Methods In a prospective nested casecontrol study, critically ill patients who were admitted to the ICU ward of a tertiary hospital were followed up as a cohort. They were divided into the case group and the control group according to the acute kidney injury, and the clinical basic characteristics of both groups were compared. Multivariate logistic regression was used to analyze the influencing factors of AKI in critically ill patients.Results Totally 426 critically ill patients meeting the inclusion criteria entered the cohort, with 112 patients in the case group and 314 patients in the control group. There were significant differences between both groups in gender, age, APACHE II score, number of extrarenal organ failure, severe infection, CKD, hypertension, diabetes, surgery, arterial oxygen partial pressure, lactic acid, blood calcium, serum creatinine, platelets, blood urea nitrogen, serum creatinine, aspartate aminotransferase, and brain natriuretic peptide (P<0.05). Multivariate logistic regression analysis showed that the risk factors for AKI of critically ill patients included age, APACHE II score, and extrarenal organ failure. number, severe infection, CKD, surgery, serum creatinine, and brain natriuretic peptide, with the probability lower than 0.001.Conclusion Old age, high APACHE II score, extrarenal organ failure, severe infection, CKD, surgery, elevated serum creatinine, and elevated brain natriuretic peptide were major risk factors for AKI of critically ill patients, and the abovementioned abnormal indicators suggest increased risk of AKI in patients, so attention should be paid in the c
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Received: 20 October 2018
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