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| Thyroid hormone level analysis of island area pregnant women in different pregnant periods and gestational age |
| Wu Xianfeng1, Xu Haigeng2 |
1.Department of Gynecology, Zhoushan Hospital, Zhoushan 316000, China;
2.Department of Gynecology, Maternal and Child Care Service Hospital of Zhoushan |
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Abstract Objective To analyze thyroid hormones changes of island area pregnant women in different pregnant periods and gestational age. Methods Totally 3000 healthy pregnant women in island area were taken as the observation group and 600 healthy pregnant women were taken as the control group. The levels of serum total triiodothyronine (TT3), total thyroxine TT4, free FT3, FT4 and TSH levels were compared in different pregnant periods and gestational age. Median (M) and bilateral limit (P2.5, P97.5) were adopted to indicate reference range for thyroid hormone levels Results Compared with the control group, the levels of TT3 and TT4 in the early, middle and late stage of pregnancy increased significantly (P<0.05). The levels of FT3 and FT4 in early, middle and late stage of pregnancy and the levels of TSH in early and middle stage of pregnancy were lower significantly (P<0.05). TT3 and TT4 in 20 to 30 years old, 31 to 35 years old and 36 to 45 years old groups were much higher than those of the control group (P<0.05). FT3, FT4 and TSH were significantly lower than those of the control group (P<0.05). Levels of FT3, FT4 and TSH were significantly different between 20 to 30 years old group and 36 to 45 years old group, and there was no significant difference between 31~35 years old group and 36~45 years old group (P>0.05) as to various indicators. Conclusion The thyroid hormones during pregnancy change obviously in different gestational stages, and have close relationship with gestational ages. Pregnant women, especially those over 35 years old, should carry out thyroid function tests as early as possible to reduce the incidence of adverse pregnancy outcomes and improve our population and reproductive quality.
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Received: 12 December 2017
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