|
|
|
| Analgesic effect of compound lidocaine cream in lymphocyte immunotherapy |
| Ye Xiayan1, Lu Yifei2, Zheng Jiayong1, Zhang Hongping1, Xu Xiaomin1, Huang Peipei1, Zhang Xianbing1, Xia Shuqi1 |
1 Obstetrics and Gynecology Department of Wenzhou People′s Hospital, Wenzhou 350000, China;
2 Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University |
|
|
|
|
Abstract Objective To investigate the analgesic effect of compound lidocaine cream in lymphocyte immunotherapy for women with recurrent spontaneous abortion (RSA). Methods A non-randomized controlled crossover design was adopted including 110 patients with RSA who were receiving lymphocyte immunotherapy. There were two groups in this study. 30 patients, who were in group 1, used compound lidocaine cream in the first two cycles (test group). And they used placebo cream in the next two cycles (control group). The group 2 contained 80 patients. They used placebo cream in the first two cycles (control group) and compound lidocaine cream in the next two cycles (test group). After 1 hour, intradermal injection was conducted. We used numerical rating scale (NRS), Faces pain scale (Wong-Banker score) and behavioral assessment scale to assess the degree of pain. Results For test group, the mean of NRS score, Wong-Banker score and behavioral assessment scale were 5.22±0.14, 5.23±0.14 and 3.98±0.13, which were lower than the corresponding scores in the control group. For the latter, the mean of NRS score, Wong-Banker score and behavioral assessment scale were 5.78±0.14, 5.85±0.15 and 4.78±0.15. For the three assessment methods, the differences of them were statistically significant (P<0.001). However, the effects of compound lidocaine cream or placebo cream in different treatment cycles showed no significant difference (P>0.05). Conclusion For women with recurrent spontaneous abortion, compound lidocaine cream can relieve pain in the treatment of lymphocyte immunotherapy and it is worthy to be popularized in clinical practice.
|
|
Received: 19 October 2015
|
|
|
|
[1] SOMERSET DA, ZHENG Y, KILBY MD, et al. Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset[J]. Immunology, 2004,112(1):38-43.
[2] 孟庆勇,林萍,王鸣,等.配偶淋巴细胞免疫治疗反复自然流产91例分析[J].中国优生与遗传杂志,2005,13(12):57-58.
[3] PANDEY MK, THSKUR S, AGRAWAL S. Lymphocyte immunotherapy and its probable echanism in the maintenance of pregnancy in woman with recurrent spontaneous abortion[J]. Arch Gynecol Obstet, 2004, 269(3):161-172.
[4] 梅喜雪,王斌,向红,等.复方利多卡因乳膏表面麻醉效果观察[J].中国美容医学,2007,16(8):1134.
[5] 龚桂芳,鲍敏,肖青,等.复方利多卡因乳膏应用于淋巴细胞免疫治疗中的镇痛效果[J].广东医学, 2014, 35(18): 2918-2919. |
|
|
|
