血清维生素D水平与哮喘患儿病情严重程度及病情控制的相关性分析

doi:10.3969/j.issn.1006-5253.2015.04.010

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Abstract Objective To investigate the correlation between serum vitamin D₃ level and disease severity and disease control in children with asthmatic. Methods 144 cases of children with asthma were divided into mild intermittent group (n=35 cases), mild group (n=36 cases), moderate group (n=48 cases) and severe group (n=25 cases) according to the degree of the disease, and 50 cases of healthy children were selected as control group. Serum 25-(OH)D₃ level was detected in control children and asthma children and the childhood asthma control test (C-ACT) was used for evaluation of children with asthma control after 4 weeks treatment. All asthma children were divided into not controlled group, partly controlled group and completely controlled group according to the C-ACT, and serum 25-(OH)D₃ levels were compared between groups. Results There were statistically significant differences in serum 25-(OH)D₃ levels among the control group, mild intermittent group, mild group, moderate group, and severe group (P<0.05), and from control group to severe group serum, serum 25-(OH)D₃ levels gradually decreased (P<0.05). There were statistically significant differences in serum 25-(OH)D₃ levels among not controlled group, partly controlled group and completely controlled group (P<0.05), and from completely controlled group to not controlled group, serum 25-(OH)D₃ levels gradually decreased (P<0.05). Spearman correlation analysis showed that serum 25-(OH)D₃ level was negatively correlated with disease severity (r_s=-0.489, P<0.05), and serum 25-(OH)D₃ level was also negatively correlated with C-ACT score (r_s=-0.470, P<0.05). Multivariable logistic regression analysis showed that risk ratio of asthma children with severity and C-ACT score <19 points of value increased gradually when the serum 25-(OH)D₃ level decreased. Conclusion Serum 25-(OH)D₃ level is closely related to asthmatic severity and disease control, and early detection of serum vitamin D level has a certain significance in evaluation asthmatic severity and recent prognosis in children with asthma.

Key words： Asthma 25 hydroxyl vitamin D₃ Childhood asthma control test

Received: 27 March 2015

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	Zhu Bijun
	Zhang Chengwei

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Zhu Bijun,Zhang Chengwei. Correlation between serum vitamin D level and disease severity and disease control in children with asthmatic[J]. journal1, 2015, 22(4): 270-273.

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http://manu58.magtech.com.cn/Jwk_zgyytj/EN/10.3969/j.issn.1006-5253.2015.04.010 OR http://manu58.magtech.com.cn/Jwk_zgyytj/EN/Y2015/V22/I4/270

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