白藜芦醇抗垂体泌乳素瘤作用机制的研究进展

doi:10.19739/j.cnki.issn1001-9510.2020.01.018

Abstract
Figure/Table
References
Related Citation (2)

Download: PDF (936 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Prolactin-type pituitary adenoma is the highest clinically occurring pituitary tumor. Hyperprolactinemia is caused by excessive secretion of pituitary prolactin by pituitary prolactin cells, which leads to impotence infertility in male patients or menstrual disorders or infertility in female patients. At present, oral dopamine receptor agonists such as bromocriptine or cabergoline are the first choice for clinical treatment. These drugs directly affect the pituitary gland to inhibit the secretion of prolactin, thereby reducing the blood prolactin level. Approximately one-quarter of patients who remained on oral medication did not return to normal levels. Resveratrol is a polyphenolic compound extracted from plants. It is widely present in plants such as Polygonum cuspidatum and grapes, and has a variety of biological activities in the literature, such as phytoestrogens, antitumor, and cardiovascular protection. This article reviews the mechanism of resveratrol against pituitary prolactinoma and provides a new idea for the treatment of prolactin pituitary tumor.

Key words： Prolactin-type pituitary adenoma resveratrol mechanism of action

Received: 23 April 2019

PACS:

R739.4

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Bo

Cite this article:

WANG Bo. Advances in research on the mechanism of action of resveratrol against pituitary prolactinoma[J]. 滨州医学院学报, 2020, 43(1): 65-67.

URL:

http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2020.01.018 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2020/V43/I1/65

[1] 姚勇,柳夫义,王任直.垂体泌乳素腺瘤研究现状[J].神经疾病与精神卫生,2008, 8(6):480-483.
[2] ZOLI M, GUARDLDI F, FAUSTINI M,et al.Myasthenia gravis imitating pituitary apoplexy in macroprolactinoma[J].Hormones (Athens),2018,17(3):423-426.
[3] ARAUJO B,BELO S,CARALHO D.Pregnancy and Tumor Outcomes in Women with Prolactinoma[J].Exp Clin Endocrinol Diabetes,2017,125(10):642-648.
[4] WONG A, ELOY J A, COULDWELL W T,et al.Update on prolactinomas. Part 2: Treatment and management strategies[J].J Clin Neurosci, 2015 ,22(10):1568-1574.
[5] CAO S, SHEN Z, WANG C,et al.Resveratrol improves intestinal barrier function, alleviates mitochondrial dysfunction and induces mitophagy in diquat challenged piglets[J].Food Funct, 2019,10(1):344-354.
[6] YOUSEF M, VLACHOGIANNIS I A, TSIANI E.Effects of Resveratrol against Lung Cancer: In Vitro and In Vivo Studies [J]. Nutrients,2017,19(11): E1231.
[7] BAEIANI M V, CORREA F, LEISHMAN E,et al.Resveratrol protects from lipopolysaccharide-induced inflammation in the uterus and prevents experimental preterm birth[J].Mol Hum Reprod, 2017,23(8):571-581.
[8] ABED , DELALANDRE A, LAJEUNESSE D.Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts[J].Arthritis Res Ther, 2017,19(1):151.
[9] FUJIWARA K, YATABE M, TOFERZAL A,et al.Identification of M2 macrophages in anterior pituitary glands of normal rats and rats with estrogen-induced prolactinoma[J].Cell Tissue Res, 2017,368(2):371-378.
[10] ZHANG T, ZHAO B, LI J,et al.Pituitary gene expression differs in D-galactose-induced cell senescence and steroid-induced prolactinomas[J].Mol Med Rep, 2015,11(4):3027-3032.
[11] DRASTIKOVA M, BERANEK M, GABALEC F,et al.Expression profiles of somatostatin, dopamine, and estrogen receptors in pituitary adenomas determined by means of synthetic multilocus calibrators[J].Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub,2016,160(2):238-243.
[12] JENG Y J, WASTON C S.Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - the involvement of rapidly activated kinases and caspases[J].BMC Cancer,2009, 9: 334.
[13] SHIN J A, OH S, AHN J H,et al.Estrogen receptor-mediated resveratrol actions on blood-brain barrier of ovariectomized mice[J].Neurobiol Aging, 2015,36(2):993-1006.
[14] JENG Y J, KOCHUKOV M Y, WATSON C S.Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cells[J].J Mol Signal,2009,9: 334.
[15] CHAO W, XXEXIN Z, JUN S,et al.Effects of resveratrol on cell growth and prolactin synthesis in GH3 cells[J].Exp Ther Med, 2014 ,7(4):923-928.
[16] NIKNEJAD H, YAZDANPANAH G, AHMADIANI A.Induction of apoptosis, stimulation of cell-cycle arrest and inhibition of angiogenesis make human amnion-derived cells promising sources for cell therapy of cancer[J].Cell Tissue Res,2016,363(3):599-608.
[17] WANG C, HU Z Q, CHU M,et al.Resveratrol inhibited GH3 cell growth and decreased prolactin level via estrogen receptors[J].Clin Neurol Neurosurg,2012,114(3):241-248.
[18] VOELLGER B,KIRCHES E,WILISCH-NEUMANN A, et al. Resveratrol decreases B-cell lymphoma-2 expression and viability in GH3 pituitary adenoma cells of the rat[J].Onco Targets Ther,2013,9: 1269-1276.
[19] VOELLGER B,WALDT N,RUPA R,et al.Combined effects of resveratrol and radiation in GH3 and TtT/GF pituitary adenoma cells[J].J Neurooncol,2018,139(3):573-582.