生命早期使用抗生素与儿童哮喘的关联性研究

doi:10.3969/j.issn.1006-5253.2020.01.00５

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Abstract Objective To explore the effect of antibiotics on pediatric asthma (6 to 10 years old) in early life (0 to 1 years old). Methods A retrospective study was conducted. Three hundred and fifty children with asthma in our hospital from October 2015 to October 2018 were selected as the case group, and 350 non-asthmatic children who underwent health examination during the same period were selected as the control group. Results The use of antibiotics in early life was a risk factor for pediatric asthma. The use rate of antibiotics in asthmatic children was 84.3% in the case group and 52.0% in the control group. The χ2 test results showed that when antibiotics were used more than twice, or when macrolides and cephalosporins were used, the risk of pediatric asthma was increased significantly, with P<0.05. The multinomial logistic regression analysis showed that, comparisons between severe onset and mild onset, when antibiotics were used four times or more, they were more likely to suffer from severe illness (OR=3.012,95%CI=1.084-8.370).Compared with moderate onset and mild onset, when antibiotics were used four times or more and three times, they were more likely to cause moderate illness(OR=2.813，95%CI=1.358-5.826) and (OR=2.337，95%CI=1.139-4.796). The macrolide type antibiotics was more prone to moderate onset (OR=2.870，95%CI=1.483-5.555). Conclusion The use of antibiotics in early life is a risk factor for increasing the incidence of pediatric asthma. And the number and type of antibiotics used are related to the severity of asthma.

Key words： antibiotic early life pediatric asthma morbidity

Received: 20 May 2019

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	Fu Lingsu
	Huang Dike
	Zhang Keyun.

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Fu Lingsu,Huang Dike,Zhang Keyun.. Research on the correlations between antibiotics use in early life and pediatric asthma[J]. journal1, 2020, 27(1): 32-35.

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http://manu58.magtech.com.cn/Jwk_zgyytj/EN/10.3969/j.issn.1006-5253.2020.01.00５ OR http://manu58.magtech.com.cn/Jwk_zgyytj/EN/Y2020/V27/I1/32

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