银杏叶提取物联合巴曲酶治疗突发性耳聋疗效的<span>Meta分析</span>

doi:10.3969/j.issn.1006-5253.2019.02.002

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Abstract Objective To systematically evaluate the efficacy of ginkgo biloba extract (ginaton) combined with batroxobin in the treatment of sudden hearing loss and the incidences of ADRs.Methods ubmed, Cochrane Library, Wanfang Data, VIP and CNKI databases were searched with a computer. Randomized controlled trials (RCTs) of ginkgo biloba extract combined with batroxobin in the treatment of sudden hearing loss were collected. According to the requirements of Cochrane 5.1 manual, the researches were selected, the data were extracted and the quality of the research was evaluated. RevMan 5.1 software was used for metaanalysis.Results ight literatures including 899 subjects were included in this study. Compared with the control group, ginkgo biloba extract combined with batroxobin can improve the total effective rate of sudden deafness, with statistical difference ［OR=4.18, 95% CI (2.66, 6.57), P<0.00001］. The total effective rate of ginkgo biloba extract combined with batroxobin in the treatment of sudden deafness was significantly better than that of the control group, with statistical difference ［OR=2.30, 95% CI (1.70, 3.10), P<0.000 01］; and the incidence of adverse reactions (ADR) was significantly less than that of the control group.Conclusion Ginkgo biloba extract combined with batroxobin in the treatment of sudden hearing loss is effective, better than its single use, and the incidence of ADR is slight, so it is worthy of clinical promotion. However, the above conclusions need to be verified by more highquality largesample clinical controlled trials.

Key words： ginkgo biloba extract batroxobin sudden hearing loss Metaanalysis

Received: 15 February 2019

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	Liu Huiling
	Yu Wangmei
	Zheng Caixia

Cite this article:

Liu Huiling,Yu Wangmei,Zheng Caixia. Efficacy of ginkgo biloba extract combined with batroxobin in the treatment of sudden hearing loss: a Meta analysis[J]. journal1, 2019, 26(2): 85-88.

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http://manu58.magtech.com.cn/Jwk_zgyytj/EN/10.3969/j.issn.1006-5253.2019.02.002 OR http://manu58.magtech.com.cn/Jwk_zgyytj/EN/Y2019/V26/I2/85

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