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| Advances in the application of routine cytological examination based on cerebrospinal fluid in the diagnosis of central nervous system diseases |
| GAO Yue1, ZHANG Caixia2, LI Tongtong1, WANG Tao1,* |
1 Department of Clinical Laboratory,Binzhou Medical University Hospital, Binzhou 256603,Shandong, P.R.China;
2 Department of Pharmacy,Binzhou Medical University Hospital, Binzhou 256603,Shandong, P.R.China |
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Abstract Routine examination of cerebrospinal fluid is a common clinical examination item of cerebrospinal fluid. It is an indispensable monitoring item in the diagnosis, treatment and evolution of various diseases of the central nervous system. However, in the aspect of cell classification and counting, because routine examination is wet-film microscopy, it only relies on refractive power to observe and classify cells roughly and is easily disturbed by various factors to produce errors. The cerebrospinal fluid cytology examination is a meticulous microscopic examination of cells after cell collection and staining by various methods. It not only makes up for the shortcomings of routine examination, but also has its unique advantages in the identification of central nervous system diseases and cancer cells. With the development of technology, cerebrospinal fluid cytology is also developing. Many new technologies, such as the detection of lymphocyte subsets in cerebrospinal fluid by immunology and the accurate diagnosis of central nervous system tumors by cytochemical methods, have emerged. The future research route of CSF should start from three aspects: structural research, information research and hierarchical research.
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Received: 04 April 2020
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