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| The effects of tea leaves on learning,memory and cholinergic system in aged mice |
| XU Yong1, LI Jinlian2, WANG Guihua2, LUAN Haiyun1 |
1 Department of Pharmacology,College of Pharmacy,Binzhou Medical University,Yantai 264003 P.R China;
2 Functional Laboratory,Experimental Teaching Management Center, Binzhou Medical University |
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Abstract Objective To investigate the effects of 3 kinds of tea extract on learning and memory,and the effects on cholinergic nerve function in natural aging mice.Methods Eighty Kunming mice were randomly divided into 5 groups: control group,model group,green tea extract group,Qimen black tea extract group and Ya'an black tea extract group.Three-month-old mice were used in the control group,and the other groups were given 16-month-old mice.At the end of fourth week,morris water maze test analysis system was used to detect changes in learning and memory abilities of mice,and the activity of SOD,GSH and MDA in brain,the activity of ChAT in hippocampus,respectively.Results The 3 tea extract group mice displayed promote of learning and memory ability in Morris water maze test.The mice in the tea group spent significantly less time swimming towards the former position of the hidden platform compared control,and crossed the former location of the platform significantly less frequently than controls.The activities of SOD,GSH-PX and MDA in the brain were significantly increased in the tea group,and the activity of ChAT in the hippocampus was increased.Conclusion Tea extract can improve the spatial learning and memory ability of aging mice,and its mechanism may be related to enhancing the function of the central cholinergic system.
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Received: 02 April 2017
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