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| Effects of EGCG on pain behavior of mice with neuropathic pain |
| LIU Hongyan1, XU Bin2, YUE Deyong2, XU Qiao2, HU Lvping2, YANG Zhongying2, WANG Haiyan2 |
1 Department of Periodicals, Binzhou Medical University, Yantai 264003, P.R.China;
2 Xin Hua Hospital Chongming Branch Affiliated to Shanghai Jiao Tong University School of Medicine |
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Abstract Objective To investigated the anti-nociceptive effects of EGCG on neuropathic pain induced by chronic constriction of sciatic nerve injury (CCI) in mice.Methods Establish the models of the chronic constriction injury of sciatic nerve, using the von Frey, plantar, cold-plate, to assess the effect of different doses of EGCG (100, 65, 20 mg/kg) on mechanical, radiant, thermal respectively.Results Compared with CCI group,EGCG of 100, 65 mg/kg could improve the operated lateral paw withdrawal threshold, prolong the operated lateral paw withdrawal latency and reduce the counts of the operated lateral paw withdrawal (P<0.05). Conclusion EGCG can alleviate CCI-induced neuropathic pain.
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Received: 07 March 2019
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