|
|
|
| Comparison of the efficacy of liver elastic modulus with noninvasive serum score systems in diagnosis of liver fibrosis of patients with chronic hepatitis B |
| ZHANG Wenxiao1 , ZHANG Haijing2, WANG Kun1, LI Rui1, LI Baowei1 |
1 Department of Ultrasonic Medicine , Binzhou Medical University Hospital ,Binzhou 256603, P.R. China;
2 Department of Ultrasonic Medicine, Binzhou People’s Hospital |
|
|
|
|
Abstract Objective To study the liver elastic modulus index(EI) measured by SWE and the four commonly used fibrosis score indexes[ Aspartic acid transaminase platelet ratio index(APRI), Forns, S index, FIB-4] to evaluate the clinical significance of liver fibrosis in patients with chronic hepatitis B. Methods One hundred and twenty patients with chronic hepatitis B who were confirmed by liver biopsy guided by ultrasound from May 2016 to July 2018 were measured with SWE technology, and the relevant serum biochemical indicators were detected. Calculate the patient's APRI, Forns, S index, and FIB-4. The degree of liver fibrosis in all patients was divided into S0-S4, and those who ≥ S2 were considered to have significant liver fibrosis. Using the ROC curve to evaluate the value of liver elastic modulus and four fibrosis scores in the diagnosis of liver fibrosis. Results Liver elastic modulus had a good correlation with liver fibrosis classification (R=0.776, P & lt; 0.05). The area under the ROC curve for the diagnosis of liver fibrosis with liver elastic modulus and four fibrosis evaluation indicators is: 0.86, 0.68, 0.72, 0.74, and 0.72 respectively. Conclusion The elastic modulus of liver is a noninvasive index to evaluate liver fibrosis, and it is related to the fibrosis score index. Its sensitivity and specificity are better than the fibrosis score index, and it can qualitatively evaluate the liver fibrosis degree, and provide basis for clinical diagnosis and treatment.
|
|
Received: 08 April 2019
|
|
|
|
|
|
[1] Chan H L,Sung J J.Hepatocellular carcinoma and hepatitis B virus[J].Semin Liver Dis,2006,26 (2):153-161.
[2] 武桂萍,颜学兵,王兴田,等.声触诊组织量化技术无创评价慢性肝病肝纤维化程度的初步研究[J].中国肝脏病杂志(电子版),2013,5(4):22-28.
[3] 中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(21010年版)[J].中华传染病杂志,2011,29(2):65-80.
[4] 中华医学会传染病与寄生虫病学分会、肝病学分会.病毒性肝炎防治方案[J].中华传染病杂志,2001,19(1):56-62.
[5] Friedrich R M,Buggisch P,de Knegt R J ,et al.Acoustic radiation force impulse imaging for non-invasive assessment ofliver fibrosis in chronic hepatitis B[J].J Viral Hepat,2013,20(9):240-247.
[6] Sarin S K,Kumar M,Lau G K,et al.Asian-Pacific clinical practice guidelines on the management of hepatitis B:a 2015 update[J].Hepatol Int,2016,10(1):1-98.
[7] Bavu E,Gennisson J L,Couade M,et al.Noninvasive in vivo liver fibrosis evaluation using supersonic shear imaging:a clinical study on 113 hepatitis C virus patients[J].Ultrasound Med Biol,2011,37(9):1361-1373.
[8] 安力春,范春芝,温朝阳,等.呼吸时相及探测深度对肝弹性测量值的影响[J].中国医学影像学杂志,2011,19(10):771-774.
[9] Papatheodoridis G V, Manolakopoulos S, Liaw Y F, et al.Follow up and indications for liver biopsy in HBeAg negative chronic hepatitis B virus infection with persistently normalALT:a systematic review[J].J Hepatol,2012,57(1):196-202. |
|
|
|
