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| Applied research of Dexmedetomidine Hydrochloride Injection and Butorphanol Injection in the process of non-invasive ventilation with respect to chronic obstructive pulmonary disease |
| YIN Rui1, TIAN Donghui2, WU Mengmeng1, LI Chunxiao1, ZHENG Wentao1 |
1 Intensive Care Unit(ICU),Binzhou People's Hospital,Binzhou 256600,P.R.China;
2 Department of Neurology,Binzhou People's Hospital |
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Abstract Objective To investigate the effect of Dexmedetomidine Hydrochloride Injection and Butorphanol Injection in the process of non-invasive ventilation with respect to acute exacerbations of chronic obstructive pulmonary disease.Methods There were one hundred and twenty chronic obstructive pulmonary disease patients merging with respiratory failure(type II) who accepted non-invasive ventilation.They were randomly divided into two groups:the experimental group for 60 who accepted sedation and analgesia of Dexmedetomidine Hydrochloride Injection and Butorphanol Injection in the process of non-invasive ventilation and the control group for 60 who accepted sedation of midazolam in the process of non-invasive ventilation.The following indicators were observed in the process of non-invasive ventilation: vital signs indicators such as heart rate,mean arterial pressure,respiratory rate and so on,and physical signs indicators such as oxygenation index, partial pressure of carbon dioxide,PH value and so on.The differences of occurrence rate of delirium, trachea cannula and icu stay time of the two groups were compared.Results After six hours of non-invasive positive pressure,partial pressure of carbon dioxide and heart rate in the experimental group were lower than those in the control group,while mean arterial pressure in the experimental group was higher than that in the control group (P＜0.05).There was no difference in terms of oxygenation index between the two groups. ICU stay time, mechanical ventilation time, delirium case numbers and trachea cannula cases in the experimental group were less than those in the control group.While everyday average calm object time in the experimental group was more than that in the control group.Conclusion In the process of non-invasive ventilation with respect to acute exacerbations of chronic obstructive pulmonary disease patients, Dexmedetomidine Hydrochloride Injection and Butorphanol Injection can improve man-machine synchronism and compliance and noninvasive ventilation efficiency,which is safe and effective.
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Received: 17 March 2018
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