丝裂原蛋白活化激酶信号通路与癌症相关研究进展

doi:10.19739/j.cnki.issn1001-9510.2021.04.016

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (918 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Nowadays, cancer is a serious threat to human life and health, and the incidence of cancer increases significantly year by year. Therefore, exploring the relevant signal pathways of cancer occurrence and development plays a key role in the treatment of cancer. Mitogen-activated protein kinases (MAPKs) signaling pathway exists widely in most cells in vivo, mainly transducing extracellular signals to the nucleus, and plays an important regulatory role in the proliferation, migration, invasion, apoptosis and autophagy of tumor cells. This pathway mainly includes four classical parallel pathways: JNK/SAPK, ERK1/2, ERK5 and p38 /MAPK signaling pathways, and different pathways play different roles on tumor cells after activation. In this paper, the effects of different MAPK-related signal pathways on tumors will be described.

Key words： cancer MAPKs signal transduction tumor

Received: 30 November 2020

PACS:

R730.2

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CHENG Tingting
	WANG Cheng
	PAN Xiaohong

Cite this article:

CHENG Tingting,WANG Cheng,PAN Xiaohong. Research progress of MAPKs signaling pathway in cancer[J]. 滨州医学院学报, 2021, 44(4): 302-305.

URL:

http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2021.04.016 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2021/V44/I4/302

[1] 余冬梅,安输,杨洋,等.JNK激酶在细胞凋亡中的作用及其与癌症的关系[J].中国药理学通报,2015,31(12):1641-1645.
[2] PAN L, DE SMET I. Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks[J]. Front Plant Sci, 2020, 11:1220.
[3] 周琦,刘晓瑜,刘树民.中药调控MAPK信号通路在疾病治疗中的研究进展[J].中药药理与临床,2019,35(6):176-180.
[4] ZHENG H Y, SHEN F J, TONG Y Q, et al. PP2A Inhibits Cervical Cancer Cell Migration by Dephosphorylation of p-JNK, p-p38 and the p-ERK/MAPK Signaling Pathway[J]. Curr Med Sci, 2018, 38(1):115-123.
[5] 邹俊勇.MAPK在人非小细胞肺癌中的表达及其通路在白藜芦醇抗A549细胞系增殖效应中的作用研究[D].杭州:浙江大学,2007.
[6] YANG S H, SHARROCKS A D, WHITMARSH A J. MAP kinase signalling cascades and transcriptional regulation[J]. Gene, 2013,513(1):1-13.
[7] WAGNER E F, NEBREDA A R. Signal integration by JNK and p38 MAPK pathways in cancer development[J]. Nat Rev Cancer, 2009, 9(8):537-549.
[8] MAIK-RACHLINE G, HACOHEN-LEV-RAN A, SEGER R. Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer[J]. Int J Mol Sci, 2019, 20(5):1194.
[9] PANDIAN J, PANNEERPANDIAN P, DEVANANDAN H J, et al. Identification of the targeted therapeutic potential of doxycycline for a subset of gastric cancer patients[J]. Ann N Y Acad Sci, 2020, 1467(1):94-111.
[10] YANG S, LIU G. Targeting the Ras/Raf/MEK/ERK pathway in hepatocellular carcinoma[J]. Oncol Lett, 2017, 13(3):1041-1047.
[11] JIN H R, DU C H, WANG C Z, et al. Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death[J]. Phytother Res, 2019, 33(3):610-617.
[12] WANDERI C, KIM E, CHANG S, et al. Ginsenoside 20(S)-Protopanaxadiol Suppresses Viability of Human Glioblastoma Cells via Down-regulation of Cell Adhesion Proteins and Cell-cycle Arrest[J]. Anticancer Res, 2016, 36(3):925-932.
[13] PENG B, HE R, XU Q, et al. Ginsenoside 20(S)-protopanaxadiol inhibits triple-negative breast cancer metastasis in vivo by targeting EGFR-mediated MAPK pathway[J]. Pharmacol Res, 2019, 142:1-13.
[14] MAO J D, WU P, HUANG J X, et al. Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma[J]. World J Gastroenterol, 2014, 20(35):12542-12550.
[15] ZHOU G, YANG J, SONG P. Correlation of ERK/MAPK signaling pathway with proliferation and apoptosis of colon cancer cells[J]. Oncol Lett, 2019, 17(2):2266-2270.
[16] CAPPELLO P, BLASER H, GORRINI C, et al. Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells[J]. Oncogene, 2014, 33(18):2375-2384.
[17] FAN W D, CHEN T, LIU P J. NIMA related kinase 2 promotes gastric cancer cell proliferation via ERK/MAPK signaling[J]. World J Gastroenterol, 2019, 25(23):2898-2910.
[18] XIE H, PALLERO M A, GUPTA K, et al. EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCgamma signaling pathway[J]. J Cell Sci, 1998,111(Pt 5):615-624.
[19] PROVENZANO P P, INMAN D R, ELICEIRI K W, et al. Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage[J]. Oncogene. 2009, 28(49):4326-4343.
[20] CAO Q, MAO Z D, SHI Y J, et al. MicroRNA-7 inhibits cell proliferation, migration and invasion in human non-small cell lung cancer cells by targeting FAK through ERK/MAPK signaling pathway[J]. Oncotarget, 2016, 7(47):77468-77481.
[21] LIN W, ZHONG M, LIANG S, et al. Emodin inhibits migration and invasion of MHCC-97H human hepatocellular carcinoma cells[J]. Exp Ther Med, 2016, 12(5):3369-3374.
[22] CHENG B, RONG A, ZHOU Q, et al. CLDN8 promotes colorectal cancer cell proliferation, migration, and invasion by activating MAPK/ERK signaling[J]. Cancer Manag Res, 2019, 11:3741-3751.
[23] 姚琴,任明姬,赵鹏伟.MAPK转导通路在肿瘤发生发展中的作用[J].内蒙古医学杂志,2014,46(10):1198-1201.
[24] SANTEN R J, SONG R X, MCPHERSON R, et al. The role of mitogen-activated protein (MAP) kinase in breast cancer[J]. J Steroid Biochem Mol Biol, 2002, 80(2):239-256.
[25] 谢瑶.RN181通过p38-MAPK对肝癌细胞HepG2凋亡及自噬的影响[D].衡阳:南华大学,2016.
[26] BECCAFICO S, MOROZZI G, MARCHETTI M C, et al. Artesunate induces ROS- and p38 MAPK-mediated apoptosis and counteracts tumor growth in vivo in embryonal rhabdomyosarcoma cells[J]. Carcinogenesis, 2015, 36(9):1071-1083.
[27] XU Y, SUN Q, YUAN F, et al. RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway[J]. J ExpClin Cancer Res, 2020, 39(1):174.
[28] OJULARI O V, CHAE J B, LEE S G,et al. Apoptotic effect of jaceosidin on MCF-7 human breast cancer cells through modulation of ERK and p38 MAPK pathways[J]. Nat Prod Res, 2020, 14: 1-5.
[29] GAN L, WANG J, XU H, YANG X. Resistance to docetaxel-induced apoptosis in prostate cancer cells by p38/p53/p21 signaling[J]. Prostate, 2011, 71(11):1158-1166.
[30] SALIM H, AKBAR N S, ZONG D, et al. miRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence[J]. Br J Cancer, 2012, 107(8):1361-1373.
[31] LIM S J, LEE Y J, LEE E. p38MAPK inhibitor SB203580 sensitizes human SNU-C4 colon cancer cells to exisulind-induced apoptosis[J]. Oncol Rep, 2006, 16(5):1131-1135.
[32] HO C J, GORSKI S M. Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer[J]. Cancers (Basel), 2019, 11(11):1775.
[33] WANG J, LI J, CAO N,et al. Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK[J]. Onco Targets Ther, 2018, 11:7777-7786.
[34] CHRISTOWITZ C, DAVIS T, ISAACS A,et al. Mechanisms of doxorubicin-induced drug resistance and drug resistant tumour growth in a murine breast tumour model[J]. BMC Cancer, 2019, 19(1):757.
[35] BRYANT K L, STALNECKER C A, ZEITOUNI D, et al. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer [J]. Nat Med, 2019, 25(4):628-640.