15 April 2018, Volume 41 Issue 2

    

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  Transplantation of a hepatocye cell line Chang liver cell improves the survival of acute liver faliure

  YANG Tao, WANG Jing, LI Yuming, YU Xingquan, SUN Qinglei, ZHU Jun, SONG Bingtan

  滨州医学院学报. 2018, 41(2): 81-86.

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  Objective To verify the function of hepatocytes by in vitro experiments and in vivo acute hepatic failure model and search for a novel cell source for liver support system.Methods the expressions of specific hepatocyte markers were detected by western-blotting and laser confocal microscopy to evaluate the hepatocytic function of Chang Liver cells in vitro. Related gene expression of hepatic function was detected by RT-PCR.The acute liver failure (ALF) model was established by 90% partial hepatectomy.Chang Liver cells were intra-splenically implanted 24 hours before the surgery and the serum samples were collected per 24 hours to test the liver functions. And the survivals were assessed.Results In vitro, conspicuous expression of hepatocytic markers,such as albumin (ALB),uridine diphosphate glucuronosyltransferase (UGT) and cytochrome P450 3A4 (CYP3A4) in Chang Liver cells.RT-PCR also exhibited the expression of related genes at mRNA level.In vivo,the survival of rats receiving Chang Liver cells was significantly improved and reached 40% against 0% in controls.Liver functions of rats receiving Chang Liver cells were also significantly improved 24 h after ALF,which was evidenced by the decreased levels of alanine transaminase (ALT), aspartate aminotransferase (AST), bilirubin and alkaline phosphates (ALP) in blood samples of rats implanted with Chang liver cells.Conclusion Chang Liver cells express hepatocytic markers and significantly improve liver function and survival after ALF, which can serve for liver support systems cells.
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  Establishment and application of multiplex touchdown PCR system for detection of two kinds of Marine vibrio in Weihai region

  XU Xiaojun, WU Yulong

  滨州医学院学报. 2018, 41(2): 87-89.

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  Objective To develop a multiplex touchdown PCR system for simultaneous detection Vibrio vulnificus and Vibrio alginolyticus and analyze the detection rate of Marine vibrio in weihai foodborne diseases.Methods The fecal specimens of patients with suspected foodborne diseases were separated, cultured and analyzed,two pairs of specific primers were designed based on vvhA gene of Vibrio vulnificus and toxR gene of Vibrio alginolyticus and detected primer specificity with primer-BLAST.The primers were used to establish multiplex touchdown PCR, and detected 93 fecal specimens, and the results were compared with the bacterial culture method.Results 45 cases of Marine vibrio were detected in fecal samples from patients with suspected foodborne diseases, mainly by the Vibrio parahaemolyticus, followed by Vibrio vulnificus and Vibrio alginolyticus.Multiplex touchdown PCR established two genes of pathogenic bacteria (vvhA, toxR) DNA detection limit were 104 CFU/mL, 103 CFU/mL;Compared with the bacterial culture method, the sensitivity and total sensitivity reached 100%. The specificity of vvhA and toxR gene was 96.47% and 95.45% respectively, and the total specificity was 95.95%.Conclusion The system of multiplex touchdown PCR detection we established can be used in the rapid diagnosis and epidemiological investigation of foodborne infection caused by Vibrio vulnificus and Vibrio alginolyticus.
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  Comparison of primary clinical efficacy of traditional decompression with precise decompression in the treatment of cervicalspondylotic radiculopathy in posterior percutaneous endoscopic cervical discectomy

  SUN Ning, SUN Zhaozhong, LIU Xin, LI Rui, REN Jiabin, HUANG Zhen

  滨州医学院学报. 2018, 41(2): 90-93.

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  Objective To compare of primary clinical efficacy of traditional decompression with precise decompression in the treatment of cervicalspondylotic radiculopathy in PPECD.Methods 39 cases of cervicalspondylotic radiculopathy of PPECD surgery were selected and divided into two groups,group A 23 cases of patients with precise decompression,group B16 cases of patients with conventional decompression.The peration time,intraoperative blood loss, intraoperative fluoroscopy,grinding bone window size,visual analogue scale (VAS), the Japanese Orthopaedic Association score (JOA) and the improvement rate of JOA of two groups were compared.Results Two groups of patients could obtain satisfactory clinical efficacy after operation. The perioperative parameters such as operation time, intraoperative blood loss, intraoperative fluoroscopy times, and maximum length of bone window grinding were significantly different between the two groups of A and B. The VAS score and JOA score of the two groups were significantly improved after operation compared with those before operation.Between group comparison,after 1, 3, 6 month, the A score and JOA score in group VAS are significantly better than those in group B; after 3 days and 12 month, there was no significant difference in VAS and JOA scores between the two groups.Conclusion Satisfactory clinical efficacy can be obtained by two PPECD Methods.Compared with the traditional decompression, the precise decompression can effectively reduce the fluoroscopy times and narrow the grinding range of the bone window, reduce the amount of bleeding during operation, shorten the operation time and improve the safety of operation.
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  The therapeutic effect of Roux-en-Y radical gastrectomy combined with gastric bypass surgery on gastric cancer with diabetes mellitus

  SUN Qinglei, LI Yuming, JIANG Hong, JIN Yongjun, WU Fengjie, YU Xingquan, SONG Bingtan, LI Hesheng

  滨州医学院学报. 2018, 41(2): 94-97.

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  Objective To investigate the therapeutic effect of Roux-en-Y radical gastrectomy combined with gastric bypass surgery on gastric cancer with diabetes mellitus.Methods Clinical data of 60 gastric cancer patients with type 2 diabetes mellitus was retrospectively analyzed.The patients were randomly divided into two groups,one group received conventional Roux-en-Y gastric cancer radical operation and the other group Roux-en-Y radical gastrectomy combined with gastric bypass surgery. The postoperative complications,postoperative Length of stay,fasting plasma glucose (FBG) ,2 hours postprandial blood glucose (2hPG) ,Insulin resistance index (HOMA-IR) were tested 1 day before operation and 1 month after operation.Results The two groups of operations were performed successfully with postoperative 10～21 d of hospital stay, all patients recovered well with good status of diet. No severe postoperative complications were found in all patients.The FPG,2 hPG of the group with Roux-en-Y Radical Gastrectomy Combined with Gastric Bypass surgery decreased significantly better than the other group form 1 day before operation to 1 month after surgery, also the insulin sensitivity index of the combined operation group was more obvious improvement, while the patients were no significant difference in body weight loss before and after surgery.The quality of life of all the patients is very well.Conclusion The complication of the Roux-en-Y radical gastrectomy combined with gastric bypass surgery does not increase, this combined operation has no effect on the radical area of gastric cancer, and the patient's diabetes disease improves greatly after the operation. It should to be a more suitable surgical treatment on gastric cancer combined with Type 2 diabetes.
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  The radiosensitive effect of acetazolammide on esophageal carcinoma cell lines E9706

  WAN Jinliang, XING Shaozhi, WANG Feng, ZHANG Weiming, YANG Zhimin, WANG Zhenbo

  滨州医学院学报. 2018, 41(2): 98-100.

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  Objective To investigate the radiosensitizing effect and mechanisms of acetazolammide,a carbonic anhydrase IX inhibitor,on esophageal carcinoma cell lines E9706.Methods Inhibitory effect of acetazolamide on E9706 cells was assayed by MTT assay. After incubation with 1μM acetazolammide,E9706 cells were irradiated by X-ray at different doses (0,2,4,6,8 Gy).The cells were assayed for clonogenic survival to determine the radiosensitizing effect of acetazolammide.Flow cytometry was used to analyze cell cycle.Western blot was used to detect the expression of Bax and Bcl-2.Results Acetazolamide had a dose-dependent and time-dependent inhibitory effect on E9706 cells.At the concentration of 1 μM,acetazolamide has radiosensitizing effect on E9706 and the sensitivity enhancement ratio (SER) was 1.40.Cell cycle analysis showed that acetazolamide increased the proportion of cells in G2/M phase.Western blot showed that acetazolamide upregulated the expression of Bax protein,down regulated the expression of Bcl-2 protein.Conclusion Acetazolamide had radiosensitizing effect on esophageal cancer cell lines E9706 by increasing the proportion of cells in G2/M phase and induced apoptosis.
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  The value of initial clinical data to evaluate the prognosis of patients with acute paraquat poisoning

  LIU Li, SUN Bin, HAN Haixia, MA Shipeng, WANG Ruixia, QIU Jianqing

  滨州医学院学报. 2018, 41(2): 101-104.

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  Objective To analyse the relationship of initial clinical datas with the prognosis of patients with acute paraquat poisoning on admission.Methods Patients with acute paraquat poisoning were retrospectively analyzed.Results The dose and Plasma concentration of paraquat of survival group was lower than that of death group significantly.ALT,AST,DBIL,BUN,CREA,AMY,CK-MB and WBC level of survival group were lower than those of death group significantly.IBIL and neutrophil percentage hadn't obvious difference compared with death group.Logistic regression analysis found that plasma concentration of paraquat had obvious influence on survival.Conclusion Plasma concentration of paraquat is the key factor to the survival of patients. Initial clinical data can be used to preliminarily evaluate the condition of patients with paraquat poisoning, and it can help predict prognosis.
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  Values of promoter hypermethylation of MGMT gene in Bronchoalveolar lavage fluid on the diagnosis of non-small cell lung cancer

  YUAN Qun, ZHANG Jianyin, CHEN Qian, MA Wei, ZHANG Miao, LI Youjin, ZHUAN Bing

  滨州医学院学报. 2018, 41(2): 105-108.

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  Objective To discuss the diagnostic value of the promoter hypermethylation of MGMT gene of Bronchoalveolar lavage fluid (BALF) on non-small cell lung cancer.Methods 98 patients underwent chest surgery were selected as study subjects;63 patients,pathologically diagnosed as non-small cell lung cancer, were enrolled in this study.35 patients with benign lesions were selected as the control group.Serum samples,BALF specimens and biopsy specimens were taken from different groups;MGMT gene promoter methylation level for the specimens was detected.Results The positive rates of promoter methylation of MGMT gene in lung cancer tissues,BALF specimens and the serum samples was 58.7%,52.4% and 27%, respectively.The positive rates of promoter methylation of MGMT gene in lung cancer tissues and the values of BALF specimens coincided with each other.While the consistency of promoter methylation of MGMT gene with lung cancer tissues and that of serum specimens is poor.The sensitivity of benign or malignant tumors detection was lower than that of BALF specimens. In the group of 35 patients with benign lesions,the methylation of the MGMT gen was not detected in the biopsy specimens,the BALF specimens and the serum samples; the incidence of methylation was 0.Conclusion Methylation detection of MGMT gene in BALF had certain clinical application value in the diagnosis of non-small cell lung cancer.
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  The relation between Helicobacter pylori infection and expression of Ki67,EGFR in gastric cancer

  WU Fengjie, ZHU Jun, ZHAO Dahua, HU Baoguang, SUN Changhua

  滨州医学院学报. 2018, 41(2): 109-111.

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  Objective To explore the correlation between HP (Helicobacter pylori) infection and the expression of Ki67,EGFR in patients with gastric cancer.Methods 76 patients with gastric cancer were included in this study.Rapid urease test was used for detection of HP,immunohistochemistry was used to test expression of Ki67 and EGFR.Chi-Square test,Fisher's exact test and Spearman correlation was using to investigate the correlationship between HP infection and expression of Ki67 and EGFR in gastric tumor tissues.Results 41 cases of 76 patients with gastric cancer were HP positive,with a positive rate of 53.94%. Expression of Ki67 and EGFR was significantly higher in HP positive group than that in HP negative group,and an obviously negative correlation was found between HP infection and expression of Ki67 and EGFR.Conclusion The expression of Ki67 and EGFR was significantly higher in gastric cancer patients with HP infection than the patients without HP infection, which indicated that HP could promote development of gastric cancer via promotion of cell proliferation and tumor angiogenesis.
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  A study on the expression and significance of HIF-1α on the maternal-fetal interface of fetal growth restriction

  XIE Shidi, ZHANG Haihong, WAN Bin, LIU Xiuxiang, LUO Yao

  滨州医学院学报. 2018, 41(2): 112-115.

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  Objective To study the expression of HIF-1α on maternal fetal interface between normal full-term newborns and fetal growth restriction (FGR) fetus and discuss the effect of HIF-1α and its target gene in the pathogenesis of FGR.Methods This study used classic ELISA method to detect the content of various substances in maternal blood,umbilical cord blood,cmaternal and child tissue surface of two groups by uniform linear calculation.Conducted a comparative analysis of the content of HIF-1α in poly formaldehyde fixed and wax embedded placental tissue of two groups,the test results were based on the content of HIF-1α calculated by standard curve,after the tissue sections being immunohistochemical stained and fluorescence stained,examine the expression of HIF-1α on the maternal surface and child surface.Microscope was used to observe the histological changes and the display intensity was determined by quantitative analysis by the image analyzer.The changes of inner organization structure in two sample cells were observed through an electron microscope, and the followed analysis is based on above mentioned observations.Results Immunohistochemical stains and immunofluorescence staining showed strong positive on the sub surface of FGR placenta.Compared the maternal surface of FGR with the maternal surface of normal full-term new born,the difference had no statistical significance;compared the placenta sub surface of FGR with the placenta sub surface of normal full-term, the difference had statistical significance;compared the maternal blood of FGR with the maternal blood of normal full-term fetus,the difference had nostatistical significance;compared the umbilical cord blood of FGR with the umbilical cord blood of normal full-term one, the difference had statistical significance.Conclusion The expression of HIF-1α on FGR placenta sub surface and the level of umbilical cord blood are significantly increasing by reducing the blood flow of the sub surface of placenta via inducing vascular endothelial injury, posing impact on the blood supply to the fetus,and induce chronic hypoxia, which plays an important role in the pathogenesis of FGR.
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  Clinical efficacy of bronchoscopic injection of Amikacin in the treatment of bronchiectasis and its influence on inflammatory factors

  ZHANG Xueping, MA Xiaofen, ZHAO Na, WANG Meng, ZHAI Yunqing

  滨州医学院学报. 2018, 41(2): 116-118.

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  Objective To analyze the therapeutic effect of bronchoscopic injection of Amikacin on bronchiectasis and its influence on inflammatory factors.Methods A total of 72 patients with bronchiectasis were selected,they were randomly divided into control group and observation group,two groups were given routine medical treatment.The control group was intravenous injected with Amikacin and bronchoalveolar lavage with physiological saline,and the observation group was given Amikacin by bronchoscope, the clinical effect was synthetically analyzed.Results The total effective rate of the observation group (97.22%) was higher than that of the control group (83.33%);the symptoms disappeared and antibiotic application time was shorter than that in the control group,and the difference was statistically significant (P＜0.05);CRP,MMP-9 and IL-6 inflammatory factors after treatment were significantly lower in the observation group than that in the control group,P＜0.05.Study showed that 25 cases were markedly effective,10 cases effective,1 cases ineffective,the total effective rate was 97.22%,16 cases of control group were markedly effective,14 cases effective,6 cases ineffective, the total effective rate was 83.33%,there was significant difference between groups (χ²=3.9560,P＜0.05).Conclusion Bronchoscopic injection of Amikacin can significantly improve the bronchiectasis symptoms and inflammatory factors and improve the curative effect.
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  The analgesic effect of single-shot femoral nerve blockade combined with local drug injection on knee joint after total knee arthroplasty

  QIU Fengyan, SHEN Mingli, LI Lin, JIN Changzhu

  滨州医学院学报. 2018, 41(2): 119-123.

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  Objective To discuss the analgesic effect of single-shot femoral nerve blockade combined with local drug injection on knee joint after total knee arthroplasty (TKA).Methods 30 patients undergoing unilateral total knee arthroplasty (TKA) were collected and randomly divided into A,B,C three groups, each group of 10 cases.The postoperative analgesia Methods of three groups are as follows:Group A was single-shot femoral nerve blockade;Group B was local drug injection in knee joint;Group C was single-shot femoral nerve blockade combined with local drug injection in knee joint.The VAS pain scores at different times in the three groups of paints after TKA in the static and active state,the numbers of sleep interruption caused by pain in the evening and later night of the postoperative, the number of using PCA (patient control analgesia),the utilization rate of postoperative analgesic drugs and the incidence of postoperative adverse reactions were Observed.Results The VAS scores of group C at different time points after TKA in the static and active state was lower than that of group A and B. The number of sleep interruptions caused by pain in the evening and later night of the postoperative of group C was lower than that of group A and B. The numbers of using PCA (patient control analgesia) and the utilization rate of postoperative analgesic drugs of group C were lower than that of group A and B.There was no significant difference of the incidence of postoperative adverse reactions in the three groups.There was no significant difference on each observation index between group A and B.Conclusion The method of single-shot femoral nerve blockade combined with local drug injection in knee joint had good postoperative analgesic effect on patients with TKA.
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  Comparison of curative effect between two kinds of posture extracorporeal shock wave lithotripsy for treating upper ureteral calculi

  SONG Lichao, ZHANG Zhongjun, ZHANG Hanlin, MA Ben, WANG Jinzhen, JIN Changzhu

  滨州医学院学报. 2018, 41(2): 124-126.

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  Objective To compare the efficacy and safety of extracorporeal shock wave lithotripsy (ESWL) in treating upper ureteral calculi length diameter ≥1.0 cm in upper ureteral calculi by comparing ipsilateral prone position and prone supine position, exploring effective posture for treating upper ureteral calculi by extracorporeal shock wave lithotripsy (ESWL).Methods 30 cases of upper ureteral calculi were collected and randomly divided into ipsilateral prone group and ipsilateral oblique supine group followed by 2 weeks.VAS scores within 24 hours after lithotripsy were statistically significant.Stone drainage rate after 2 days was observed,after 1 week and 2 weeks stone discharge rate after lithotripsy and postoperative complications occurred after lithotripsy.The effectiveness and safety of ESWL therapy for upper ureteral calculi were analyzed compared with those of two postures.Results There were no significant differences between two groups, including sex,age,weight stone,side stone,shock times and stone length diameter.VAS scores of pain within 24 hours after lithotripsy were observed within 24 hours after lithotripsy and there was no significant difference between postoperative 2 days postoperatively.However,there was significant difference between the two groups in stone clearance rate after 1 week and 2 weeks. There was statistical significance between two groups in the incidence of post-lithotripsy hematuria.Conclusion ESWL treatment of upper ureteral calculi with long diameter ≥1.0 cm is less than ipsilateral prone position after ipsilateral oblique supine position and long term stone drainage rate is higher than ipsilateral prone position. It is an effective and safe therapeutic posture.
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  The influence of Acitretin combinating with NB-UVB and calcipotriol on patients with psoriasis and expression of IL-17,IL-22,IL-23

  YANG Pengfei, ZHANG Yujie

  滨州医学院学报. 2018, 41(2): 127-131.

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  Objective To discuss the influence of Acitretin combinating with NB-UVB and calcipotriol on patients with psoriasis and expression of IL-17,IL-22,IL-23.Methods 108 cases of complete information on patients with severe plaque psoriasis vulgaris, according to the random number table were divided into A,B,C three groups:Group A take NB-UVB method of total body irradiation for treatment three times a week;after Group B in the morning and evening after cleaning skin lesions topical calcipotriol ointment; Group C together for joint A and B treatment,all of them were with low-dose oral acitretin.The whole treatment course was eight weeks.Observed and compared the clinical efficacy of the three groups of patients,PASI and DLQI score, tested the changes of levels of IL-17,IL-22,IL-23 in patients with severe plaque psoriasis vulgaris in peripheral blood serum.Results Acitretin combined with NB-UVB and/or calcipotriol ointment treatment of severe plaque psoriasis vulgaris can cause decrease of PASI score,DLQI score and levels of their inflammatory cytokines IL-17,IL-22,IL-23 in patients with severe plaque psoriasis vulgaris in peripheral blood serum were lower than before therapy.And the level of reduce PASI score,DLQI score,IL-17,IL-22,IL-23 was most notable with the patients were treated by Acitretin combinate with NB-UVB irradiation efficacy and calcipotriol ointment.The clinical treatment time can be shortened,and enhance the patient's resistance to improve the quality of life of patients.Conclusions Effects of Acitretin combined with NB-UVB irradiation and calcipotriol treated the patients with severe plaque psoriasis vulgaris were most significantly. Acitretin combined with NB- UVB and calcipotriol can be used to treat severe plaque psoriasis vulgaris and should be popularized.The level of IL-17,IL-22,IL-23 decreased more obviously in the treatment of Acitretin combined with NB- UVB and calcipotriol. The level of IL-17,IL-22,IL-23 in patients' eripheral blood serum can be used to evaluate the severity of psoriasis and therapeutic effect.
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  A retrospective study on the clinical efficacy of spironolactone in the treatment of female acne

  LI Xinxin, FAN Qizhong, BO Mingxiang, HU Limin, WANG Yu, ZHANG Yanmin

  滨州医学院学报. 2018, 41(2): 132-134.

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  Objective To retrospectively study the safety and efficacy of spironolactone in the treatment of female acne.Methods The clinical data of a group of women who received spironolactone to treat acne were selected by an electronic medical records search tool to assess the comprehensive acne severity scale before treatment and at each follow-up.The condition of concurrent and previous treatment and adverse reactions were collected at all follow-up.Results The acne symptom of 94 patients in a total of 110 patients improved and 61 completely cured.16 patients had no improvement and 6 patients were recurrent after initial improvement.The acne of face,chest,back had been improved by 73.1%, 75.9%,77.6%, respectively in female patients.51 patients had adverse reactions,6 patients of who discontinued medication.Conclusion Spironolactone has a good effect on the treatment of female acne and has a low recurrence rate.
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  Curative effect observation of autologous erythropheresis of unilateral total hip arthroplasty

  FANG Kun, REN Xiaoning, SONG Xuezhen, WANG Hua

  滨州医学院学报. 2018, 41(2): 135-136.

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  Objective To provide a more efficient autologous blood preparationstrategy for total hip replacement (THR) and promote the popularization and application of autologous erythropheresis technology in THR surgery.Methods 16 patients underwent unilateral total hip replacement were chosen as the research objects (apheresis group).These patients treated with preoperative autologous erythropheresis and allogeneic blood for intraoperative transfusion.18 THR patients were chosen randomly who were only transfused allogeneic bloods as control objects (control group). The data of blood routine in pre-erythropheresis or pre-operation, the intraoperative blood loss,the volume of allogeneic blood transfusion and the first day blood routine post-operation in were collected and analyzed statistically. Results The volume of allogeneic erythrocyte in the apheresis group was (1.56±1.41) U,compared with (2.67±1.14) U of control group,the difference was statistically significant. However, the rest observation index differences were not statistically significant. Conclusion The application of autologous erythropheresis technology in THR which has a large amount of blood preparation could reduce the amount of transfusion of allogeneic erythrocyte,but caused no significant changes in blood routine indicators and intraoperative blood loss, which is worthy to being used for THR surgery.
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  Effects of long-term hospitalization on the cognitive function in male patients with schizophrenia

  ZHONG Ming, LIU Chuanpeng, LIU Gang, CUI Minghu

  滨州医学院学报. 2018, 41(2): 137-139.

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  Objective To study the effects of long-term hospitalization on the cognitive function in male patients with schizophrenia.Methods 30 male long-stay patients with schizophrenia ( inpatient group),32 male long-term follow-up outpatients with schizophrenia (outpatient group), and 26 healthy controls (control group) were assessed for cognitive function using the Wisconsin Card Sorting Test (WCST),Spatial Span Test,Digital Sequence Test and The Tower Of London Test (TOL).Results The inpatient and outpatient group performed poorer on the entire neuropsychological test than health control group.The scores of inpatient group on every test were significant lower than control, except forward score of the Spatial Span Test.Conclusion Long-term hospitalization aggravates cognitive impairment in male patients with schizophrenia.
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  The clinical research about the application of positron emission tomorgraphy magnetic resonance imaging and conventional magnetic resonance imaging on detecting malignant tumors

  DENG Jing, WU Wenqiang, LI Jiarong, WANG Renguo, HE Zhiwei, ZHAO Zhilin, RUAN Sheng, CHEN Shuilian

  滨州医学院学报. 2018, 41(2): 140-142.

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  Objective To compare the application value of positron emission tomorgraphy magnetic resonance imaging and conventional magnetic resonance imaging on detecting malignant tumors and provide theoretical basis for the clinical diagnosis of malignant tumors.Methods 117 cases of patients with malignant tumor were selected as the study object, and given the conventional magnetic resonance detection (normal group) and magnetic resonance imaging detection (research group),test results of two groups were compared.Results 117 patients with malignant tumor were detected with 110 (94.02% accuracy) and 82 cases (70.09% accuracy).Group and routine group for primary lesion,the transfer of STD focal also differences, tissue invasion detection rate, the team was much higher than that of conventional group.Conclusion Positron emission tomorgraphy magnetic resonance imaging has high diagnostic accuracy in the diagnosis of malignant tumors with high accuracy,and the primary lesion,transfer venereal stove,tissue invasion detection aspect, which shows that positron emission tomorgraphy magnetic resonance imaging has confirmed critical significance in malignant tumor detection.