15 February 2019, Volume 42 Issue 1

    

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  Applied anatomy foundation of the I-shaped memory alloy vertebroplasty frame for osteoporotic vertebral compression fracture

  ZHANG Xibing, CHEN Shujun, YAO Xia, WANG Chunxiao, TANG Xiaojie, CAO Haifei, SONG Qinyong

  滨州医学院学报. 2019, 42(1): 1-4. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.001

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  Objective To explore anatomic features of T₁₀～L₂ vertebraes, and provide parameters for the development of the I-shaped memory alloy vertebroplasty frame (IMAV) for osteoporotic vertebral compression fracture (OVCF).Methods Twenty sets of thoracic lumbar spine specimens (T₁₀～L₂) of Chinese normal adults were used to measure the anatomic parameters. IMAVF was designed according to the parameters.Results As L₁ for example:Transverse diameter of the pedicle was about (6.52±1.33) mm,longitudinal diameter of the pedicle was (13.46±2.37) mm,sagittal diameter of the vertebral body was (32.64±2.38) mm, respectively.IMAVF was composed of a I-shaped body and two deformable wings at up and down,including large, medium and small types.Conclusion The designation of IMAVF is feasible anatomically,and it is safe and easy to treat osteoporotic vertebral compression fractures.
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  The analysis of 236 patients with drug eruption in hospital

  DING Changling, MA Zhenzhen, GAO Fei, CHENG Wenna, ZHANG Junhua, DING Zhaoxing, TIAN Yuejie

  滨州医学院学报. 2019, 42(1): 5-8. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.002

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  Objective To analyze the clinical medication,rationality of using drugs and costs of medication in hospital of patients with drug eruption in hospital and provide reference of rational drug use,prevention of drug eruption and establish phytotoxicity compensation system.Methods The aspects of patients` general data,medications,types of drug eruption,hospitalization cost and the length of hospital stay of 236 patients who were treated in hospital for drug eruption were retrospectively analyzed.Results 190 patients were causative drugs identified,including 97 cases of oral administration and 63 cases of intravenous administration.The first causative drug was antibiotics,followed by Chinese patent medicine,antipyretic-analgesic drugs and antiepileptics.221 were slight drug eruption and 15 were severe drug eruption.The average length of hospital stay was (10.75±9.56) days, and the average medical costs were (8356.50 ± 2198.45) Yuan for 236 drug eruption cases.Conclusion Rational use of drug plays an important role in the prevention of drug eruption.Therefore,medical personnel should strengthen rational drug use propaganda and establish phytotoxicity compensation system to ensure the safety of patients.
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  The effects of miRNA-132 on proliferation and apoptosis of leukemia cell line K562

  FAN Yunxiu, LI Jianchang, SUN Weimei, CHEN Bo

  滨州医学院学报. 2019, 42(1): 9-12. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.003

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  Objective To investigate the effect of miRNA-132 on proliferation and apoptosis of leukemia cell line K562, and explore its possible mechanism.Methods K562 cells were transfected with LipofectamineTM 2000.The expression of miRNA-132 was detected by real-time quantitative PCR.The effect of transfection on proliferation and apoptosis of K562 cells was detected by CCK-8 and flow cytometry.The protein expression levels of SRIT1 and P53 were detected by Western Blot.Results The expression of miRNA-132 in normal cells was significantly lower than that in K562 cells.Compared with the blank group and the negative control group,the expression of miRNA-132 was significantly increased in the transfected group.K562 cells’ proliferated and the apoptosis rate decreased significantly after transfection of miRNA-132 mimics.Compared with the blank control group and miRNA-132-NC group,after the high expression of miRNA-132,the expression of SIRT1 protein in the transfected group was significantly decreased,and the expression of P53 protein was significantly increased.Conclusion Highly expression of miRNA-132 significantly inhibits the proliferation of leukemia K562 cells and induces the apoptosis,which may be related to the enhancement of SIRT1 and P53 activity.
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  The clinical effect of proximal fibular osteotomy combined with drilling decompression in the treatment of knee osteoarthritis

  LI Lin, QIU Fengyan, XU Lin

  滨州医学院学报. 2019, 42(1): 13-16. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.004

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  Objective To compare the clinical effects of the proximal fibular osteotomy combined with drilling decompression and simple proximal fibular osteotomy in the treatment of knee osteoarthritis (KOA) dominated by medial compartment lesions.Methods 45 cases of knee osteoarthritis patients were divided into treatment group (23 cases) and control group (22 cases) based on the random number table.Treatment group was given the proximal fibular osteotomy combined with drilling decompression;control group was given the simple proximal fibular osteotomy.The visual analogue scores (VAS) in the static, the hospital special surgery (HSS) scores, femoral tibia angles of the two group patients at different time points were recorded and compared.Results The observation indexes of the two groups were significantly improved compared with those before operation.The VAS scores in the static at different time points after operation of the treatment group was significantly lower than that of the control group.The HSS scores at different time points after operation of the treatment group was significantly higher than that of the control group.There was no significant difference in femoral tibial Angle between the two groups pre-operation and 7 days after operation, the femoral tibia angle of the treatment group was significantly decreased than that of the control group at 3 and 6 month after operation.Conclusion proximal fibular osteotomy combined with drilling decompression can significantly relieve the rest pain of the patients with knee osteoarthritis, and promote the treatment effect of simple proximal fibula osteotomy, and improve the function of knee joint better.
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  Analysis on the distribution and drug resistance of common pathogenic bacteria of ventilator-associated pneumonia

  HUANG Qianqian, HUANG Xianzhong, MA Lan, ZHOU Xiuzhi

  滨州医学院学报. 2019, 42(1): 17-19. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.005

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  Objective To investigate the distribution and drug resistance of pathogenic bacteria of ventilator-associated pneumonia and provide reliable evidence for the early,rational and effective use of antibiotics to avoid the occurrence of multidrug resistance.Methods A total of 51 patients with ventilator-associated pneumonia were analyzed.112 strains of pathogenic bacteria were isolated from sputum samples.The identification of pathogenic bacteria and the detection of drug sensitivity were carried out by using the Mellier identification and drug sensitivity detection system of France.Results Among 112 strains of pathogenic bacteria,Gram-negative bacilli accounted for 75.89%.The main pathogens were Acinetobacter baumannii,Pseudomonas aeruginosa,Klebsiella pneumoniae,eosinophils.Gram-positive bacteria accounted for 16%,mainly Staphylococcus aureus.Fungi accounted for 11%,mainly Candida albicans.Acinetobacter baumannii and Pseudomonas aeruginosa had severe multidrug resistance.Acinetobacter baumannii were more resistant to cephalosporins, penicillin, quinolones and carbapenes than 50%. The resistance rate of Pseudomonas aeruginosa to ampicillin / sulbactam was 100%.Conclusion The rate of multidrug resistance or pan-resistance of pathogenic bacteria of ventilator associated pneumonia is high.According to the data of drug resistance monitoring of bacteria,the antibiotics should be used reasonably in clinic.
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  Analysis of effect of age and drinking on damage mode and severity of electric vehicle accidents

  LI Mintao, SUN Shengfang, JIA Zhuting, DOU Lianfeng, MA Huili, CHEN Xi, LI Jianjun, CUI Shouyong

  滨州医学院学报. 2019, 42(1): 20-23. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.006

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  Objective To investigate the effect of age and drinking on damage mode and severity of electric vehicle accidents to optimize their surgical diagnosis and treatment.Methods A retrospective observational study was performed on 620 adult patients who were admitted to hospital because of electric vehicle accident.According to blood alcohol concentration,all pateints were divided into drinking group and awake group.Their damage mode and severity were analyzed separately.Results The elderly group was more susceptible to limb injury and multiple injuries. Compared with the awake group, the drinking group was prone to head and face injury, and the severity of injury was higher.At the same time, the patients of drinking group were younger.Conclusion In the electric vehicle accidents,the damage mode of the young and middle-aged group and the elderly group was different.The limb injury and multiple injuries were more likely to occur in the elderly group,and the limb injuries were more serious.In addition,drinking alcohol could affect the damage mode of electric vehicle accidents, and increase the risk of head and face injuries.
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  Investigation about blood glucose control and life quality of children with type 1 diabetes mellitus

  LIU Fang, ZHANG Yingxian, WEI Haiyan

  滨州医学院学报. 2019, 42(1): 24-26. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.007

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  Objective To investigate the status of blood glucose control and quality of life in children with type 1 diabetes mellitus (T1DM).Methods A total of 98 children with T1DM were randomly selected for investigation,and the blood samples were collected,and the quality of life control and quality of life status were evaluated by the quality of life measurement scale.Results The glycosylated hemoglobin (HbAlc) level of 98 children was (7.63±1.97) %.The blood glucose control of children with T1DM was related to age,disease duration,diabetes diet,blood glucose self-monitoring,diabetes education,place of residence and economic level.Young age,short disease duration,diet control,frequent monitoring of blood glucose level and diabetes education receiving were protective factors for good control of blood glucose level in T1DM children.The scores of physiological function and psychosocial function and the total score in good blood glucose control group were significantly higher than those in poor blood glucose control group.Conclusion Blood glucose control and quality of life can be improved by means of strengthening diet control, blood glucose monitoring, disease education and other ways.
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  Determination of total flavonoids of Chrysanthemum indicum extract

  SONG Dehai, XU Qianqian, SUN Yingdong, LI Baoyuan, GUO Shijin, ZHANG Jinjie

  滨州医学院学报. 2019, 42(1): 27-29. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.008

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  Objective To determine the total flavonoids content of Chrysanthemum indicum extract by polyamide column. Methods The sample of Chrysanthemum indicum was heated to reflux by 60% ethanol to get the crude extract.The extract was purified by polyamide chromatography column with different concentrations of ethanol,and the content of the total flavonoids in different eluent layers was determined by UV-Vis spectrophotometry.Results The yield of 50% ethanol eluent in Chrysanthemum indicum extract was 0.9753% and the dry ointment rate was the highest. The content of flavonoids in 70% ethanol eluent was 46.51% and the content was the highest.Conclusion The method using polyamide chromatography column is accurate, sensitive, simple and reproducible,and it provides a scientific basis for the enrichment and purification of flavonoids of Chrysanthemum indicum.
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  Content determination of paeoniflorin in chaixiangshugan capsule by HPLC

  XIAO Lu, LI Shucui, LUAN Haiyun, ZHANG Shuping

  滨州医学院学报. 2019, 42(1): 30-32. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.009

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  Objective To determinate the content of Paeoniflorin in Chaixiangshugan Capsule by HPLC.Methods High performance liquid chromatography (HPLC) method was used, which applied InertSustain-C18 column (4.6 mm×150 mm,5 μm) and acetonitrile -0.1% orthophosphoric (14∶86) as mobile phase.The flow rate was 1.0 mL/min, and detection wavelength was 230 nm.Results The linear range was 0.1172～2.344 μg and correlation coefficient was 0.9999.The average recovery was 99.05%, and the relative standard deviation was 2.08%.Conclusion HPLC method can be applied to the determination of Paeoniflorin in Chaixiangshugan Capsule.
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  Investigation about parental stress of parents whose children with nephrotic syndrome

  WANG Jinrong, ZHANG Min, GAO Junfang, LI Ming'e

  滨州医学院学报. 2019, 42(1): 33-35. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.010

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  Objective To investigate the situation of parental stress of parents whose children with nephrotic syndrome and understand the level of parental stress of these parents.Methods The parents of 200 children with nephrotic syndrome were selected,and their parental stress was investigated by self-designed general situation questionnaire and parenting stress index-short from. Results The average score of parental stress of parents whose children with nephrotic syndrome was (93.41±11.09),which was significantly higher than the normal stress.In the three dimensions,the highest score was parental distress,and the lowest score was parent-child interaction disorder.Conclusion Most parents whose children with nephrotic syndrome have higher parental stress. Medical staff should take appropriate intervention measures to help them relieve the psychological and mental stress caused by the children's disease.
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  The influence factors on cognitive impairment of male methamphetamine addicts during withdrawal

  WANG Yan, CHENG Mei

  滨州医学院学报. 2019, 42(1): 36-38. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.011

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  Objective To investigate the influence factors on cognitive impairment of male methamphetamine addicts during withdrawal.Methods A total of 421 male methamphetamine addicts were investigated. The self-designed questionnaire,SAS,SDS,MoCA were used.Results 249 methamphetamine addicts had cognitive impairment in this study.Binary logistic regression analysis indicated that methamphetamine addicts’age,education, depression on cognitive impairment was significant during withdrawal.Conclusion Methamphetamine addicts with older age,lower education,and depressive symptom are more likely to suffer cognitive impairment.Intervention should be implemented for male methamphetamine addicts of differents ages and education to alleviate the symptoms of depression and reduce cognitive impairment.
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  Predictive value of different scales on the risk assessment of deep venous thrombosis in stroke patients

  YANG Ru, XU Renhua

  滨州医学院学报. 2019, 42(1): 39-41. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.012

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  Objective To study the predictive value of Padua scale,Autar scale and Caprini scale on the risk assessment of deep venous thrombosis (DVT) in stroke patients.Methods The clinical data of 162 stroke patients were retrospectively analyzed.According to the Results of Doppler ultrasonography,the patients were divided into DVT group and control group.Padua,Autar and Caprini scales were used to assess the risk of DVT occurrence.The evaluated Results of the scales were compared,and the receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to analyze the predictive value of each scale on the risk of DVT in stroke patients.Results There were 37 cases of DVT in 162 stroke patients, and the incidence rate was 22.84%. The Padua scale score and proportion of high-risk patients in DVT group were higher than those in control group.The ratio of Autar scale and high-risk patients was higher than that of control group,and the Caprini scale score and proportion of extremely high-risk patients were higher than those in control group.The AUC value of Padua scale was greater than that of Autar sclae and Caprini scale, and the difference in the former was not statistically significant, and the difference in the latter was statistically significant, and the AUC value of Autar scale was greater than that of Caprini scale.Conclusion Padua, Autar and Caprini scales all have high accuracy in the assessment of DVT risk in stroke patients, and they are helpful for identifying DVT high-risk factors and adopting targeted preventive measures.
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  Clinical observation of comprehensive nursing intervention in prevention of lower limbs deep venous thrombosis in elderly patients with intertrochanteric fracture during perioperative period

  NIU Yanyan

  滨州医学院学报. 2019, 42(1): 42-45. https://doi.org/10.19739/j.cnki.issn1001-9510.2019.01.013

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  Objective To evaluate the effectiveness of comprehensive nursing intervention on the prevention of deep venous thrombosis (DVT) of lower limbs during perioperative period in elderly patients with intertrochanteric fracture.Methods The incidence of DVT was observed and compared in 120 elderly patients with intertrochanteric fracture by D- dimer monitoring and color doppler ultrasound examination of deep veins in both lower extremities.Results There was no significant difference in D-dimer test Results between the two groups on the postoperation first day, and the comparison of D-dimer test Results at day 7,14,21 postoperation showed statistically significant difference.A total of 10 of the 120 patients had DVT in the lower limbs,including 2 in the experimental group and 8 in the control group.Conclusion Nursing intervention, as a comprehensive nursing measure to prevent deep venous thrombosis, can effectively reduce the incidence of lower limbs DVT.