Objective To investigate the status of exercise self-efficacy in patients with lung cancer and analyze its main influencing factors.Methods Totally 257 lung cancer patients who received chemotherapy in our hospital from January 2021 to June 2022 were selected as the research objects. General information questionnaire, Cancer Fatigue Scale and Exercise Self-Efficacy Scale for Lung Cancer Patients were used for investigation. Multiple linear regression analysis was used to analyze the influencing factors of exercise self-efficacy in patients with lung cancer.Results The score of cancer-related fatigue in lung cancer patients was (33.62±6.01). The score of exercise self-efficacy was (82.87±6.28). Cancer-related fatigue, education level and regular exercise habit were the main influencing factors of exercise self-efficacy in lung cancer patients (P<0.01).Conclusion The level of exercise self-efficacy of patients with lung cancer is low, and cancer-related fatigue can affect the level of exercise self-efficacy of patients. It is necessary to strengthen the health education of lung cancer patients to improve the level of exercise selfefficacy.