Objective To investigate the clinical value of ultrasound real-time shear wave elastography (SWE) in evaluating renal function in patients with diabetic kidney disease (DKD), and thus to provide evidence for elary diagnosis and clinical treatment of DKD. Methods Sixty-two patients with DKD and 14 cases with normal renal function were collected from June 2016 to May 2019.There were 21,24 and 17 cases in the early nephropathy,clinical nephropathy and uremia groups among the DKD patients,respectively.All subjects received conventional ultrasound,SWE and99mTc-DTPA renal dynamic imaging examination. The differences of conventional ultrasound parameters,mean Young′s modulus Emean) and glomerular filtration rate (GFR) were analyzed. The nonlinear relationship between GFR and Emean was fitted according to the scatter diagram, and the quation was established.Results There was no significant difference in conventional ultrasound parameters (length, physical evidence, volume) between steps groups (P >0.05). SWE parameters-Emean was gradually increased in left kidney, right kidney and both kidneys from the early nephropathy group (lowest) to the uremia group (highest), and the difference was statisticalally significant compared with the control group (P <0.05). Among the subgroups of DKD,the uremia group was the highest,and the early nephropathy group was the lowest, and the difference between each DKD subgroup was statistically significant (P <0.05). The level of total GFR in each DKD subgroup decreased, and the difference was statistically significant, compared with that in the control group (P <0.01). As the total GFR level of radiolabels decreases,the average Emean value gradually increases. Growth curve fitting was made to establish the equation E (Y)=exp (5.789-0.417X)(P <0.001), and the fitting effect was good (R2=0.918). The sensitivity ands pecificity were 77.4% and 83.1% while Emean threshold was 3.53 kPa in the early stage group,sensitivity and specificity were 80.8% and 90.2 while Emean threshold was 4.49 kPa in the clinical nephropathy group,and sensitivity and specificity were 83.5% and 92.6% while Emean threshold was 5.47 kPa in the uremia group,respectively.Conclusion SWE possesses high diagnostic efficiency in the diagnosis of renal dysfunction in DKD,which has important clinical significance in the early diagnosis and treatment of DKD.
Objective To explore the prognosis and is risk factors of acute cerebral infardt (ACI) patients after the treatment with venous thrombdlysis.Methods Totally 178 ACI patients after treatment of venous thrombolysis were caried out a following-up survey within 3 months.These patients were divided into the good prognosis group(102 cases)and the por progno-sis group(76 cases)according to the evaluation of prognosis. The incidencerate o por prognosis of ACI patients after venous thrmbolysis treatment was descriled, and the risk factors of por prognosis were screened.Results The incidence rate of poor prognosis of ACI patients after enous thrombolyis reatment was 42.70%(76/178).The risk factos of por prognosis included hypertension(OR =6.589),thrombolysis time window(OR=3.162),NIHSS score before thrombolsis(OR=6.058),blod glucse before thrombolysis(OR=3.452)and cerebral hemorhage after thrombolysis(OR =4.039),but improwement of neuro-logical symptoms after 24h of thromblysis(OR=0.135)was the protective factors of poor prognosis. Conclusion ACI patients sill have a high incidence mte of por prognosis after venous thrombolyis. To aim directly at these above high risk factors,ACI patients should be caried out venous thrombolyis in the thrombolysis time window, and prevention measures should be early a-doped, to improve prognosis of ACI patients.
Objective To analyze the hospitalization expenses under the missed abortion clinical pathway managementmodel,and to provide a basis for controlling the unreasonable growth of medieal expenses and realizing the effective use of medical resources.Methods The data of clinical path with missed abortion patients from tertiary hospitals of Shenzhenwere colleeted,descriptive analysis,cluster analysis and single factor analysis of variance(anova) were used to analyze the medical expenses structure and compare the medical expenses level. Results The cost of hospitalization varied greatly among patients withmissed abortion in clinical pathway in different hospitals. Diagnosis expenses, comprehensive medical service expenses and treatment expenses were the main components of the hospitalization expenses for the missed abortion patients.The results showedthat,in hospitals with high total hospitalization expenses,the expenses of all items were higher or the expenses of some itemswere higher than those in other hospitals.Conclusion With the implementation of clinical pathway treatment for the same disease,there is a large gap in medical charges between hospitals,and the distribution difference of various medical expenses is different.Hospitals should strengthen clinical pathway management,standardize diagnosis and treatment behavior,guarantee medical quality,and control unreasonable increase of hospitalization expenses
Objective To explore the risk factors of suicide behavior of bipolar disorder (BPD)patients, and proride prevention measures for it. Methods Totally 540 BPD patients were carried out a follow-up survey,and these patients were divided into the suicide behavior group (194 cases) and the non-suicide behavior group(346 cases)according to suicide behavior. The risk factors of suicide behavior of BPD patients were respectively screened by single factor and multiple factors stepwise Logistic regression methods.Results The rate of suicide behavior in these 540 cases of BPD was 35.93%.The risk factors of suicide behavior of BPD patients included female (OR=1.846),family suicide history (OR=3.117),history of major trauma (OR=4.154),depression degree (OR=5.254),poor interpersonal relationships (OR=2.801) and a sense of worthlessness or guilt(OR=3.615). Conclusion BPD patients have a high rate of suicide behavior, and there are many independent riskf actors affecting suicide behavior. Psychiatrists should pay atteation, and prevention measures should be adopted early, to reducesuicidal tendencies and suicide behavior.