YANG Menglu, SUN Weimei, LI Xiaohua, LI Jianchang
Objective To investigate the factors affecting the prognosis of children immune thrombocytopenia,and to establish a clinical scoring system for the prognosis of children immune thrombocytopenia.Methods (1)Data of 206 children with immune thrombocytopenic treated in our hospital from March 2016 to February 2019 were statistically analyzed.Gender,age,i-nitial platelet count,bleeding,infection,and therapeutic effect were recorded,respectively.Moreover,the number of megakaryocytes of 103 children who underwent bone marrow biopsy were recorded.(2)Outpatient and telephone follow-up were conducted for the children.(3)To make univariate and multivariate Logistic regression analysis on the prognostic factors.(4)To assign reasonable scores to risk factors and to calculate the relationship between score and prognosis.Results Among 206 cases with immune thrombocytopenic,170 cases had a good prognosis and 36 had a poor prognosis;among the 103 cases who underwent bone marrow biopsy,76 cases had good prognosis and 27 cases had poor prognosis.The results of statistical analysis showed that there were statistically significant differences in age,prodromal infection,bleeding,initial platelet count and initial Megakaryocyte count,without statistically significant differences in gender or treatment.In the multivariate Logistic regression analysis,the independent risk factors affecting prognosis were age,bleeding,prodromal infection,initial platelet count and initial Megakaryocyte count.The above factors were assigned and the total score was calculated.The results showed that the lower the score was,the better the prognosis was.Conclusion Age,bleeding,prodromal infection,initial platelet count and initial Megakaryocyte count have important predictive significance for the prognosis of immune thrombocytopenia and can be used to guide the treatment.
