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15 December 2018, Volume 41 Issue 6
    

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  • VNTR analysis of molecular typing of Pseudomonas aeruginosa in nosocomial infection
    MENG Wei, LIU Yongyun, JI Bing, LI Jinling, AN Xinye
    滨州医学院学报. 2018, 41(6): 401-403.
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    Objective To investigate the effect of multi-loci VNTR analysis on molecular typing of multi-drug-resistance pseudomonas aeruginosa.Methods Seventy-eight strains of multi-drug-resistance pseudomonas aeruginosa were isolated from 13 departments of our hospital from May 2015 to May 2017,and their DNA was extracted.Eight sites of pseudomonas aeruginosa were randomly selected from the genome of pseudomonas aeruginosa,and the DNA was amplified by VNTR amplification.The products were extracted by capillary electrophoresis.The relative molecular mass of the amplified product and the number of VNTR repeats at different sites of the strain were calculated.Multidrug-resistant pseudomonas aeruginosa was subjected to cluster analysis and homology analysis based on the relative molecular mass of the amplified product and the number of VNTR repeats at different sites.Results The repeat base sequence size of 8 VNTR sites was 7-128 bp,the polymorphism index was 0.47-0.89,and the distribution was relatively uniform.VNTR analysis was applied to divide 78 multi-drug-resistance pseudomonas aeruginosa into 5 groups.In 6 patients,the repeat number of different isolates was the same at 8 sites.Conclusion VNTR analysis method has high application value in the genotyping study and the control of epidemic tracing of pseudomonas aeruginosa. It can provide a basis and technical method for the control of nosocomial infection, which requires high attention.
  • Effects of Betulinic Acid on the proliferation and apoptosis of glioma U251 cells
    LI Yuanyuan, SUN Ruili, ZHANG Yuanyuan, ZHU Shuxia
    滨州医学院学报. 2018, 41(6): 404-406.
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    Objective To observe the effects of Betulinic Acid (BA) on proliferation and apoptosis of human glioma U251 cells, and explore its possible mechanism.Methods Different concentrations (0,2.5,5,10,20,40,80 μg/mL) of BA was added in U251 cells which grew in logarithmic phase and stable status, and the cells were cultured for 24,48,and 72 hours.CCK-8 method and Annexin V-FITC/PI double staining method were used to detect the proliferation and apoptosis of U251 cells.Western blotting was used to detect the expression changes of apoptosis related proteins including Bcl-2 and Bax, and signaling pathway proteins including Akt and phosphorylated Akt (p-Akt).Results Within the range from 0 to 80 μg/mL,BA could inhibit U251 cells' s proliferation and promote the apoptosis (P＜0.05).In addition, the results manifested the concentration and time dependence,and with the increase of concentration of BA and the extension of time, the expression level of Akt in U251 cells had no obvious change (P＞0.05),while the expression level of P-Akt and Bcl-2 gradually reduced (P＜0.05),and Bax expression level increased (P＜0.05).Conclusion BA can obviously inhibit the proliferation and induce apoptosis of U251 cells, which may be related to the down regulation of the signal transduction pathway protein PI3K/Akt.
  • Clinical value of autofluorescence bronchoscopy for the diagnosis of central airway lung cancer
    ZHAI Nailiang, LIU Jinping, CAO Guohong, XIA Yongfu, CUI Shuhua, WANG Xiaozhi, LYU Changjun
    滨州医学院学报. 2018, 41(6): 407-410.
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    Objective To investigate the value of using autofluorescence bronchoscopy (AFB) for the detection of central airway lung cancer.Methods Totally 72 patients suspected of lung cancer were examined by AFB and white light bronchoscopy (WLB).All abnormal findings were recorded and biopsies were taken for pathological examination.Finally, the sensitivity and specificity of the two methods were compared.Results Among the 72 patients, 61 were classified as positive by pathology,including 3 severe dysplasia,19 small cell lung cancer and 39 non-small cell lung cancer which included 25 squamous carcinoma,11 adenocarcinoma and 3 without classification. AFB was used to detect 57 abnormal cases and 54 cases were pathologically confirmed as positive.WLB was used to detect 46 cases and 39 cases were confirmed positive.The relative sensitivity of AFB and WLB in the detection of central airway lung cancer was 88.5 % and 63.9 %, respectively,with statistical significant difference (P＜0.05).The specificity was 78.6% vs 61.1 %, without statistical difference (P＞0.05).Conclusion The sensitivity of AFB combined with WLB was better for the diagnosis of central airway lung cancer, especially helpful for the early diagnosis of lung cancer.
  • Clinical and imaging studies of pulmonary benign metastasizing leiomyoma
    WANG Min, LIU Jian, ZHANG Zhiqiang, QI Kai, WANG Shuo, WANG Liangjie
    滨州医学院学报. 2018, 41(6): 411-413.
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    Objective To study the clinical and imaging findings of pulmonary benign metastasizing leiomyoma.Methods The clinical and imaging findings of 21 cases of PBML in China and 1 case of PBML in our hospital were summarized and analyzed.Results All PBML patients were female,with an average age of 44 years.All patients had a history of uterine leiomyoma surgery.50% of the PBML cases were found in physical examination.The time from the first uterine fibroids operation was from 1 month to 23 years, and the median time was 10 years. The imaging findings were as follow: double lung or single lung multiple nodules in 82% cases; 5% showed bilateral lung scattered in miliary tubercle;5% combined with subpleural mass;9% combined with other site metastasis and bone destruction; all cases had no lymph node enlargement and pleural effusion; in 3 enhanced scan cases,2 cases showed significant enhancement, and 1 case showed no enhancement; 4 cases underwent PET-CT, while there were no obvious radioactivity. 86% cases ER and PR were (+), 5% was only ER (+),and 5% was only PR (+).Conclusion Most of the PBML patients are women of childbearing age, most of which have the history of hysteromyoma surgery. There are no obvious clinical symptoms, and the imaging features are not typical, just like double lung metastasis.Therefore, women with childbearing age have several lesions in the lungs after myomectomy for several years. We should take BML into account without the history of malignant tumors.
  • Analysis of risk factors related to Ventricular Aneurysm formation in Acute anterior wall Myocardial Infarction
    SUO Baojuan, KAN Xiaoyu, LI Yang, CHENG Yanli
    滨州医学院学报. 2018, 41(6): 414-417.
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    Objective To analyze the risk factors related to the formation of left ventricular aneurysm (LVA) after acute anterior wall myocardial infarction.Methods Totally 114 patients with acute anterior wall myocardial infarction were divided into the LVA group (44 cases) and the non-LVA group (70 cases) according to the occurrence of LVA.Routine check was performed including brain natriuretic peptide (BNP), hypersensitive C-reactive protein (hs-CRP), and echocardiography.Results The levels of BNP and hs-CRP in the LVA group were significantly higher than those in the non-LVA group (P＜0.05).The time between the admission to the hospital and percutaneous coronary intervention (PCI) in the LVA group was significantly longer than that in the non-LVA group (P＜0.05).Conclusion The levels of BNP and hs-CRP may be helpful for the formation of LVA in acute anterior wall myocardial infarction, and the early opening of PCI can effectively reduce the incidence of LVA.
  • Selection of surgical procedures between PPECD and TcPECD
    SUN Ning, HUANG Zhen, LIU Xin, LI Rui, REN Jiabin, LI Yuefei, SUN Zhaozhong
    滨州医学院学报. 2018, 41(6): 418-420.
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    Objective To analyze operative efficacy and complications of posterior percutaneous endoscopic cervical discectomy (PPECD) and transcorporeal percutaneous endoscopic cervical discectomy (TcPECD),providing a basis for selection of surgical procedures.Methods Totally 38 patients with single segment cervical spondylosis were treated in our department from May 2014 to April 2015. There were 32 cases of PPCED in group A including 20 female cases and 12 male cases, and 6 cases of TcPECD in group B including 4 female cases and 2 male cases.The operation time, the height of the responsible intervertebral space before and after operation,postoperative complications,hospital stay and other clinical parameters were counted.Visual analogue score was used to evaluate the incision pain one day,two days and three days after operation, and the neck pain and upper extremity radiation pain one month, three months, six months and twelve months after operation.The cervical spine of all patients was examined by CT+ and MRI in the follow-ups one month, three months, six months and twelve months after operation.Results ]The VAS scores of postoperative neck pain and upper extremity radiation pain in both groups were lower than those before operation. There was no significant difference between the two groups one month, three months, six months and twelve months after operation (P＞0.05). VAS scores of the incision pain of the two groups decreased to different degrees one day to three days after operation, and there was no significant statistical difference. Postoperative imaging showed that the operation site was accurate, the height of intervertebral space in group A had no significant change after surgery, while that in group B was significantly lower than that before surgery.The difference between the two groups was statistically significant. In group A, there were 4 cases of skin hypoesthesia, and 1 case of swelling of left thumb and index finger;while in group B 1 case of slight collapse of vertebral body and 3 cases of reduction of intervertebral space.Conclusion The two methods of operation are satisfactory.TcPECD is more suitable for cervical spondylotic myelopathy with central protrusion (free) from the intervertebral space horizontally upward or downward.PPECD is more suitable for cervical spondylotic myelopathy with nerve root type and paracentral type.
  • Curative effect of cervical posterior single open-door laminoplasty plus single lateral mass screw-rod for myelopathic cervical spondylosis with cervical kyphosis
    SHAO Bin, WANG Dawei, XING Jianqiang, SUN Jinchuan, ZHANG Zheng, ZHAO Wei, YE Weikang, FANG Qingmin
    滨州医学院学报. 2018, 41(6): 421-424.
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    Objective To investigate the curative effect of cervical posterior single open-door laminoplasty plus single lateral mass screw-rod internal fixation for myelopathic cervical spondylosis with cervical kyphosis.Methods From Jan.2013 to June 2016,23 patients with cervical spondylotic myelopathy treated with cervical posterior single open-door laminoplasty plus lateral mass screw-rod were selected,including 11 males and 12 females, with the ages from 55 to 72 years old and with a mean age of 65 years old. All of them received cervical posterior single open-door laminoplasty plus lateral mass screw-rod.Three days and one year after the operation,the cervical vertebra X ray and MRI were reviewed and the changes of cervical curvature were observed.One year after the operation,JOA scoring statistics were performed on the neurological function of patients,and the improvement rate of neurological function was calculated.Results All the 23 patients received cervical posterior single open-door laminoplasty plus lateral mass screw-rod Under the general anesthesia.The mean operative time was 65min ranging from 50 to 80min. The mean volume of blood loss was 120ml ranging from 50ml to 200ml. Preoperative JOA score was from 5 to 10,with the average 7.5±2.0, while one year after the operation the score of JOA was from 10 to 16,with the average of 13.3±2.1, which was significantly higher than the preoperative score.Preoperative cervical Cobb angle was from -21to -29° with the average 26.1±2.3°.Three days after the surgery,X showed a Cobb Angle of -6.5±2.9°,which was better than that before the surgery, and the patient was significantly relieved.One year after the surgery,the Cobb Angle was shown to be -7.2±2.6°, which was better than that before the surgery.Conclusion These results indicate that the cervical posterior single open-door laminoplasty plus single lateral mass screw-rod can improve cervical curvature and has reliable curative effect.
  • A clinical randomized controlled study of different timing of oxytocin in preventing hemorrhage after cesarean section
    ZHANG Huifang, WANG Xue, WANG Liting, WANG Chengxiang, LI Qingchun
    滨州医学院学报. 2018, 41(6): 425-427.
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    Objective To comparatively analyze the clinical effects of different clinical application of oxytocin to prevent hemorrhage after cesarean section (CS).Methods Totally 100 primiparas received transverse CS in the lower segment of the uterus under combined spinal and epidural anesthesia, and were divided into the experiment group and the control group according to random number table method.The experiment group were injected 10 IU oxytocin into the uterine body after the umbilical cord amputation and another 10 IU oxytocin were dissolved in 500mL 0.9% NS for intravenous infusion. While in the control group,20 IU oxytocin were dissolved in 500mL 0.9%NS for intravenous infusion. Indicators were observed including the amount of blood loss during CS,postoperative blood loss 2 hours and 24 hours after CS,the overall blood loss, the use of additional uterotonics, the changes of blood pressure and heart rate, and operation time.Results In the experimental group, the amount of bleeding during CS and the total bleeding decreased in comparison with the control group, and the difference was statistically significant (P＜0.05).The difference of the decrease of hemoglobin and hematocrit in the two groups was statistically significant (P＜0.05).There were no statistical significant differences between both groups about other observational indicators (P＞0.05) .Conclusion Oxytocin intrauterine injection combined with intravenous drip during elective CS can achieve a good hemostatic effect. It can effectively reduce the total loss of blood in the operation and post operation, and there are no additional risks for parturients, so it can effectively replace the intravenous drip of oxytocin after the umbilical cord clipping in the single pregnancy cesarean section.
  • Research on the implementation countermeasures of health-care grading system in China based on multi-angle analysis
    DU Qing, ZHAO Yongjun, HE Xiaomin, CHEN Rentai, LIAN Wu
    滨州医学院学报. 2018, 41(6): 428-430.
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    Objective To analyze the main problems faced in our health-care grading system and provide countermeasures.Methods Literature review and policy analysis were used to analyze the implementation of health-care grading system from multiple angles.Results The top-level design of health-care grading system is not perfect,the soft power of the primary medical institutions needs to be improved, the role of economic leverage has not been exerted, the social rules for solving the problem of “difficult and expensive to see a doctor” have not been established,and the concept of medical treatment needs to be changed.Conclusion The implementation of health-care grading system is not going well,needs to prudently advance it as a systematic project.
  • Investigation and analysis on the children’s life quality under the policy of “two-children” policy
    CONG Jianni, LI Qinglin, DU Qing, ZHAO Yongjun, HUANG Xiaomin
    滨州医学院学报. 2018, 41(6): 431-432.
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    Objective To know the effect of the second child's birth on the quality of children's life and to provide the basis for improving the quality of children's life.Methods The children of the second grade were investigated by PedsQL4.0 in lanzhou city.Results 216 children were investigated.The life quality score differences were not statistically significant (P＞0.05) for the boys and girls,the physiological function score of children who had brothers or sisters was lower than that of only children(P＜0.05) with statistical significance,and other differences had no statistical significance (P＞0.05).Conclusion The overall life quality of children was low.We should strengthen health education for children especially for those who have brothers or sisters.The parents should give more love and respect,increase children’s security sense,and improve the quality of life.
  • Studying on the factors to influence breastfeeding in the city under the overall two-child policy LIU Kun ZHAO Yongjun GUO Sirou YUAN Jing DU Qing
    LIU Kun, ZHAO Yongjun, GUO Sirou, YUAN Jing, DU Qing
    滨州医学院学报. 2018, 41(6): 433-436.
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    Objective To study the status of breastfeeding and its influencing factors,and provide references for improving it.Methods The research using quantitative and qualitative research methods of 234 maternal.Quantitative data used SPSS 22.0 to analysis and qualitative data integrated after transcribing.Results The rate of exclusive breastfeeding is 63.25% and lower than the national standards.Breastfeeding has Statistically significant in different educations、delivery ways、knowledge and confidence(P＜0.05).Conclusion Effective measures should be taken to overcome the obstacles, and confidence and establish good social support should be built up,so as to raise the rate of breastfeeding.
  • Study on the cognition of osteoporosis and healthy behaviors of postmenopausal women in Muping District
    SHANG Weijing, JIANG Wei, HAN Ying, XU Qiuli, MENG Xiaoni, ZHAO Hantong, WANG Jiu
    滨州医学院学报. 2018, 41(6): 437-440.
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    Objective To study the cognition of osteoporosis and health behaviors of postmenopausal women so as to provide reference for the prevention of osteoporosis.Methods Two hundred postmenopausal women over 45 years old in Muping District were selected by stratified sampling method.Questionnaires were used to investigate the cognition, healthy behavior and preventive attitude.Results Totally 195 valid questionnaires were recovered.Only 20.5% of postmenopausal women knew the main cause of osteoporosis,and only 15.9% of postmenopausal women had regular bone mineral density.There were statistical differences in osteoporosis cognition and osteoporosis related health behaviors among postmenopausal women with different monthly income and cultural level (P＜0.05),postmenopausal women with higher monthly income had higher cognitive level and more relevant healthy behaviors,and those with higher education had higher cognitive level.There were statistical differences in health behaviors related to osteoporosis among different profession (P＜0.001).Conclusion The cognition and knowledge of postmenopausal women in Muping District is relatively insufficient, and the proportion of health behaviors is relatively low. In view of the problems in the investigation, relevant government departments should strengthen the prevention of osteoporosis and give full play to the role of mass media in the prevention of osteoporosis.
  • Investigation on the epidemic-situation of high-risk population with sheep Brucellosis
    ZHENG Fengying, HU Jianhua, GUO Hongping
    滨州医学院学报. 2018, 41(6): 441-443.
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    Objective To find out the prevalence and trend of brucellosis among high-risk population in Zhanhua District, and to provide scientific basis for prevention and control of brucellosis.Methods The antibody detection and diagnosis of brucellosis were carried out among the high-risk population in Zhanhua District from 2015 to 2017.Results Totally 1232 people at high risk of brucellosis were investigated in Zhanhua District,and the average positive rate of brucellosis antibody was 13.39%.The highest positive rate of Brucellosis antibody was 15.98% in 2017.And the difference of the positive rates of 2015 and 2016 was statistically significant (χ2=5.80 P＜0.05).The difference of positive rates of 2015 and 2017 was statistically significant(χ2=8.93 P＜0.05).The positive rate of antibody was 14.19% in the group of 21 to 70 years old and 5.26% in the age group of over 71 years old. The difference between the two groups was statistically significant(χ2=14.16,P＜0.05).The positive rate of brucella antibody in males was 16.48% and that in females was 8.64%.The difference was statistically significant (χ2=15.62,P＜0.05). Conclusion In the past three years,the positive rate of brucellosis antibody in high-risk population in Zhanhua District has been on the rise.The propaganda and education of brucellosis should be carried out by Disease Control Center and Animal Husbandry Bureau to improve the awareness of self-protection and reduce the infection rate of the population,so as to eliminate brucellosis.
  • Analysis of physical health of junior-senior high school students in rural area of Xinxiang city,Henan province
    WANG Fan, XUE Ping, LI Yushan, QI Zhihong, ZHANG Ming, LI Hongbin
    滨州医学院学报. 2018, 41(6): 444-446.
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    Objective To evaluate the physical health of adolescents in rural area of Xinxiang and provide scientific basis for promoting the health work of rural adolescents.Methods Totally 2 663 junior-high school students were selected with stratified random sampling from rural area of Xinxiang in 2017,whose health examination was carried out from three aspects including body shape,physiological function and physical quality,and the results were compared with the corresponding national indexes in 2014.Results Students aged 12 to 18 in rural areas of Xinxiang had a total detection rate of 7.96%,and the total rate of overweight and obesity was 9.61%.The lung capacity of both sexes was higher than that of the national level,and the difference was statistically significant(P＜0.001).The comprehensive score of physical fitness is divided by excellent,good, passing and failing grades, and female scored better overall than male.Conclusion The rate of low body weight,overweight and obesity of 12-18-year-olds in rural areas of Xinxiang city was high,and the level of physical fitness was lower than that of the national level in 2014.Timely intervention should be carried out to improve the physical health of rural students.
  • Value of IVIM sequence in diagnosis of prostate cancer and benign prostatic hyperplasia
    WANG Jing, MA Longbo, WANG Qianqian
    滨州医学院学报. 2018, 41(6): 447-449.
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    Objective To investigate value of the parameters of intravoxel incoherent motion (IVIM) sequence in the differential diagnosis of prostate cancer and prostatic hyperplasia.Methods Fifty cases of prostate cancer and 45 cases of benign prostatic hyperplasia were examined by magnetic resonance IVIM sequence and DWI sequence,and the ADC value,the pure diffusion coefficient (Dslow), the pseudo diffusion coefficient (Dfast) and perfusion fraction (f) value of the patients with prostate cancer and prostatic hyperplasia was compared.The parameters of prostate cancer and benign prostatic hyperplasia were established,and the ROC curve was established.The area under the ROC curve (AUC)was analyzed, and the diagnostic efficiency of each parameter was compared.Results The value of ADC and Dslow of prostate cancer was significantly lower than that of benign prostatic hyperplasia,and the value of F was higher than that of benign prostatic hyperplasia.The difference of P≤0.05 was statistically significant,and the difference of Dfast value was not statistically significant.The AUC of the Dslow below the ROC curve was the largest and the diagnostic efficiency of Dslow was the highest.Conclusion ADC, Dslow and F can differentiate prostate cancer from benign prostatic hyperplasia, but Dslow has the highest diagnostic efficiency.
  • Inhibitory effect of YC-1 on induction of Glut1 and VEGF genes in Oral squamous cell carcinoma
    WANG Fang, WANG Jingjing, LI Jianwei, MA Xiangrui, NIU Wenjuan
    滨州医学院学报. 2018, 41(6): 450-454.
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    Objective To study the function and mechanism of YC-1 on activity of Glut1 and VEGF genes in Oral squamous cell carcinoma.Methods (1) HIF-1α,Glut1 and VEGF proteins were detected by immunohistochemical methods in 60 cases of oral squamous cell carcinoma and 12 cases of normal tissue adjacent to tumor. (2) Human tongue squamous cancer cell line Tca8113 were incubated under hypoxic or normoxia conditions and were divided into the hypoxia group and the normoxic group. Different concentrations of YC-1 (0, 10, and 100 μmol/L) were added to both groups.RT-PCR was used to detect the HIF-1α,Glut1 and VEGF mRNA.Results The positive expression rate of HIF-1α,Glut1 and VEGF in OSCC was higher than that in normal tissue. Positive correlation was found between HIF-1α and Glut1,VEGF expression (P＜0.05).RT-PCR results showed that after the adding of YC-1,the expression of HIF-1α in both groups decreased,with statistical significant difference (P＜0.05).With different YC-1 concentration,the expression of HIF-1α in the hypoxia group had no dose dependence,with no statistical significant difference (P＞0.05).Glut1 and VEGF molecular expressions in human tongue squamous cancer cell line Tca8113 decreased significantly in different YC-1 concentrations (P＜0.05).The expressions of Glut1 and VEGF had dose dependence in the hypoxia group with the increase of YC-1 concentrations (P＜0.05).Conclusion The expression levels of HIF-1α,Glut1 and VEGF in oral squamous cell carcinoma are higher than those in the normal tissues.YC-1 inhibits HIF-1α,Glut1 and VEGF expressions in Tongue squamous cancer cell line Tca8113. YC-1 inhibits the growth of OSCC possibly through down-regulating the expressions of HIF-1α,Glut1 and VEGF.
  • Preliminary study on the effect of Odaph on enamel development
    ZHANG Zhen, GAO Yuguang
    滨州医学院学报. 2018, 41(6): 455-459.
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    Objective To investigate the effects of Odaph on enamel development using a transgenic animal model of Runx2 conditional knockout mice.Methods The genotypes of transgenic mice were identified by PCR,and real-time quantitative PCR was used to detect the relative expression of Amelx,Ambn,Enam,Amtn,Odam,Scpppq1 and Odaph mRNA in the mandibular molar region of Runx2loxp/loxp and K14-cre-Runx2loxp/loxp knockout mice.Finally, the expression of Runx2 and Odaph in the mandibular molar of knockout mice was detected by immunohistochemistry.Results Real-time quantitative PCR showed that compared with WT mice,the relative expression levels of Amelx,Ambn,Enam mRNA in PN10 cKO mice were up-regulated, and the expressions of Amtn,Odam,Scpppq1 and Odaph were significantly decreased.The results of immunohistochemical staining showed that anti-Runx2 was negatively expressed in the nucleus of ameloblasts of PN10 null mice,and anti-Odaph was strongly detected in the distal end of ameloblasts of PN10 WT mice.However,in cKO mice, the staining was not very obvious.Conclusion Odaph plays an important role in enamel development.
  • Effect of health education based on empowerment theory on readiness for hospital discharge of patients with acute myocardial infarction after PCI
    LI Congcong, LIUXiujing, SUN Yifen, HUO Jinqiu, SONG Qiong, LI Ming’e
    滨州医学院学报. 2018, 41(6): 460-462.
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    Objective To explore the effect of health education based on empowerment theory on readiness for hospital discharge of patients with acute myocardial infarction after PCI.Methods Based on the inclusion and exclusion criteria,92 patients enrolled in this research who were diagnosed with acute myocardial infarction and received PCI from January to September in 2018.All patients were randomly divided into the control group and the observation group.Patients in the control group accepted routine health education after PCI, while patients in the observation group accepted health education based on empowerment. The difference of the two groups of readiness for hospital discharge was assessed.Results The total score(93.55±4.21) of readiness for hospital discharge in the observation group was higher than that in the control group (89.20±2.44), with a significant difference.Conclusion Health education based on empowerment improves the readiness for hospital discharge of patients with acute myocardial infarction after PCI compared with those patients educated with routine health education,so it is worthy of application.
  • Self-concept of profession of nurses in infectious ward from General Hospitals in Shandong Province and its influencing factors
    ZHANG Yuhong, XU Qiuxian, HOU Xianghua, ZHANG Xiaoli
    滨州医学院学报. 2018, 41(6): 463-466.
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    Objective To investigate the status and influencing factors of professional self-concept of nurses in infectious wards from some general hospitals in Shandong Province, and then to provide theoretical basis for improving their professional self-concept. Methods Totally 422 nurses from 20 general hospitals above grade 2 in Shandong Province were investigated by convenience cluster sampling,general data questionnaire and Professional Selfconceptor Nurses lnstrument (PSCNI).The effect of general data on professional self-concept of nurses in general hospital infectious ward was analyzed by variance analysis.Results The total score of professional self-concept of nurses in general hospital infectious ward was (88.06+9.85),and the average score of its items was (2.94+0.33),which tended to be positive.The score of skill dimension (3.28+0.48) was the highest while the score of communication dimension (2.72+0.38) was the lowest.Age,length of career, professional title,job satisfaction in the infectious ward and the intention of leaving the present position (F= 4.063,5.743,3.762,4.276,3.285,all P＜0.05) affected the professional self-concept of nurses.Conclusion The professional self-concept of nurses in infectious ward in general hospitals could be improved in a large extent, although it is positive. Health administrative departments and hospital administrators should pay attention to optimizing the nursing working environment, implementing welfare benefits, improving career planning and management, and promoting the professional self-concept of nurses.
  • Analysis of adverse drug reaction reports of 259 cases
    WANG Tengfei, DAI Shixiao, JIANG Huiping, HAN Naiwei
    滨州医学院学报. 2018, 41(6): 467-469.
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    Objective To investigate the characteristics of the adverse drug reaction ( ADR) in this hospital,so as to provide reference and basis for clinical rational drug application.Methods ADR reports from Jan.2017 to Dec.2017 were collected for statistical analysis.Results Among the 259 ADR reports, the proportion of patients aged over 60 years was the highest, and most of the 259 cases were given intravenous administration. Among all the drugs that might induce ADR,anti-infection agents and proprietary Chinese medicine preparations had the large proportions.Clinical manifestations of the injuries in skin and its appendages and digestive system adverse reactions were the two main ADR manifestations.Conclusion We should pay great attention to the reporting and monitoring of ADR and analyze the characteristics of the ADR on a regular basis in hospitals so as to promote the rational use of drugs and ensure safe medication in patients.
30 June 2025, Volume 48 Issue 3
Journal of Binzhou Medical University
Bimonthly, Established in March 1987
ISSN 1001-9510，CN 37-1184/R
Responsible Institution
Shandong Provincial Department of Education
Sponsor
Binzhou Medical University
Editor-in-Chief: Huang Fei
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