Home
|
About Us
|
Editorial Board
|
Instruction
|
Subscribe
|
Advertising
|
Messages Board
|
Contact Us
|
中文
滨州医学院学报
Office Online
Online Submission
Peer Review
Office Work
Journal Online
Forthcoming Articles
Current Issue
Archive
Read Articles
Download Articles
Email Alert
2019 Vol. 42, No. 2
Published: 2019-04-15
81
Health economic evaluation related to nosocomial infection of patients with surgery of hypertensive intracerebral hemorrhage
TIAN Xiaoling, WANG Hongyan, SUN Jihua, ZHANG Xiaoqin, SUN Liandong, XU Hongmei
DOI: 10.19739/j.cnki.issn1001-9510.2019.02.001
Objective
To investigate the prevalence of nosocomial infection in hypertensive intracerebral hemorrhage patients by analyzing retrospective investigation of nosocomial infection in 272 patients with neurosurgical hypertensive intracerebral hemorrhage in a III-A general hospital,and to analyze the related factors of nosocomial infection and find out the infection key factors and links, in order to improve the clinical diagnosis, treatment and nursing work.
Methods
Totally 272 patients with hypertensive intracerebral hemorrhage were selectedina III-A hospital from January 1, 2015 to December 31, 2016. A retrospective survey of hospital infection in all patients with hypertensive intracerebral hemorrhage.The survey included gender, age, awareness status, presence or absence of other diseases, length of hospital stay,catheter retention time,and invasive operation and so on.The data were measured by the standard deviation, the rate and the percentage.The
χ
2
test was used to compare the count data. The T test and the rank sum test were used to measure the data. Multivariate analysis was logistic regression and
P
＜0.05 was taken as statistically significant.
Results
A total of 272 patients underwent hypertensive intracerebral hemorrhage surgery,57 patients with nosocomial infection,and the incidence of infection was 20.96%. Infection occurred in 69 cases, with the incidence 25.37%.Between 2015 and 2016,the incidence of nosocomial infection was declining.Lower respiratorytract ranked first in the parts of patients with hypertensive intracerebral hemorrhage, accounting for 59.42%.Bacterial culture was carried out for 36 infected patients and 43 strains were detected including 32 strains of Gram-negative bacteria,mainly Acinetobacter baumannii; 6 strains of Gram-positive strains,of which the most common was Staphylococcus aureus.Whether the ICU stay and the number of ICU stay days in the hospital were the independent risk factorsof hospital infection.
Conclusion
The incidence of nosocomial infection of patients with hypertensive intracerebral hemorrhage is higher than that of the general nosocomial infection in the same period.Theadmission to ICU, and the hospitalization days in ICU, is an independent risk factor for nosocomial infection in patients with hypertensive intracerebral hemorrhage.Control measures should be taken to prevent these risk factors, to shorten the time of stay in ICU, and to reduce the hospital infection rate. Hospital infection resulted in an increase in hospitalization costs and prolonged hospitalization. Increased hospitalization costs and prolonged hospitalization days were different at the sites of infection and the patients’age.
2019 Vol. 42 (2): 81-83 [
Abstract
] (
144
)
HTML
(1 KB)
PDF
(1133 KB) (
153
)
84
A meta-analysis of risk factors for neuropsychiatric lupus erythematosus
ZHOU Jun, JIN Lairun, TAO Mengjun, YUAN Hui
DOI: 10.19739/j.cnki.issn1001-9510.2019.02.002
Objective
To investigate the risk factors for neuropsychiatric lupus erythematosus (NPSLE) and provide reference for the prevention and control of this disease.
Methods
Database including CNKI,Wanfang database,Weipu database, Pubmed, Cochrane were searched for studies on the risk factors of NPSLE (including central nervous lupus and lupus encephalopathy), and Stata 12.0 was used for the meta analysis.
Results
A total of 14 studies were included, with 1 028 cases in the case group(NPSLE group) and 2 101 cases in the control group(SLE group).A total of 26 possible risk factors were investigated in this study, among which were statistically significant as follows:white ball ratio (A/G decline or A/G inversion) (OR=2.491,95%CI=1.635~3.784),red blood cell decline(OR=2.086,95%CI=1.043~4.168),platelet decrease (OR=1.512,95%CI=1.037~2.203),erythrocyte sedimentation rate (ESR) (OR=2.415,95%CI=1.665~3.503),Alanine aminotransferase (ALT) increased (OR=3.536,95%CI=2.246~5.566),aspartate aminotransferase (AST) increased (OR=5.587, 95%CI=3.582~8.713), and urinary red blood cells increased (OR=2.906,95%CI=2.079~4.064),elevated creatinine (OR=4.6053,85%CI=1.872~11.326), elevated urea nitrogen or urea (OR=3.451,95%CI=2.372~5.022),anti-ribose The body P protein antibody was positive (OR=4.779,95%CI=3.053~7.483).Subgroup analysis of NPSLE risk factors showed that the above factors except for thrombocytopenia (OR=1.305,95%CI=0.808~2.108), butterfly erythema (OR=1.634,95%CI=1.110~2.406),blood vessels Inflammation (OR=1.810,95%CI=1.224~2.678),Anti Smith(Sm) antibody positive (OR=1.638,95%CI=1.202~2.232) are risk factors for NPSLE in Chinese population.
Conclusion
The occurrence of NPSLE is related to many factors, and there may be some differences between the risk factors of this disease in Chinese population and foreign populations. However, due to limited research, the Conclusion needs further proof.
2019 Vol. 42 (2): 84-87 [
Abstract
] (
224
)
HTML
(1 KB)
PDF
(995 KB) (
112
)
88
Study on the difference of postoperative pain status of lung cancer treated by combined intravenous anesthesia and general anesthesia with epidural anesthesia
HAN Nianping
DOI: 10.19739/j.cnki.issn1001-9510.2019.02.003
Objective
To investigate the difference of postoperative pain status of lung cancer with total intravenous anesthesia (TIVA) combined with general anesthesia combined with epidural analgesia (CGEA).
Methods
A total of 91 patients with lung cancer who underwent surgical treatment were randomly divided into the TIVA group (45 cases) and the CGEA group (46 cases).In the TIVA group, midazolam 0.04 to 0.06 mg/Kg was intravenously administered intravenously;0.4 to 0.6 μg/Kg of sufentanil,0.15 mg/Kg of atracurium cis-benzensulfonate,and 1.0 mg/Kg of propofol.After induction of anesthesia was completed, laryngoscope tracheal intubation was performed and mechanical ventilation was performed. Maintenance of anesthetic method:A micropump was pumped with atracurium sulfoxamate 2 ug/(Kg·min), propofol 5 mg/(Kg·h), and remifentanil 0.15 μg/(Kg·min).CGEA group:Induction of anesthesia was the same as above.T7-T8 disc space was selected as the puncture site.Epidural puncture was performed and an epidural catheter was placed.Anesthesia was maintained. 0.5% lidocaine hydrochloride was administered through the catheter every 30 minutes.Dosing once,5 mL each time.
Results
The patients in the CGEA group were superior to the TIVA group in terms of extubation time and recovery time.The incidence of infection was lower in the CGEA group than in the TIVA group. The scores in the CGAA group were better than those in the TIVA group at 5 hours and 10 hours after the operation.
Conclusion
The choice of CGEA anesthesia for lung cancer patients can effectively improve postoperative pain and reduce complications.
2019 Vol. 42 (2): 88-89 [
Abstract
] (
215
)
HTML
(1 KB)
PDF
(976 KB) (
107
)
90
Meta analysis of efficiency and safety of air versus liquid enema reduction in the treatment of children with intussusception
SUN Shuai, GENG Lei, XU Xiaoliang, DING Guojian, ZHENG Bufeng, LIU Xijie, FENG Wenyu, FU Tingliang
DOI: 10.19739/j.cnki.issn1001-9510.2019.02.004
Objective
To compare the efficiency and safety of air versus liquid enema reduction for intussusception in children.
Methods
PubMed,Medline,Cochrane Library,Embase,VIP,CNKI,CBMdisc and Wanfang Database were retrieved.The retrieval time was from the establishment of the database to March 1st ,2018. After the detected literatures being screened,extracted and evaluated,a Meta-analysis was performed using RevMan 5.3 software.
Results
Finally,a total of 140 articles including 76 reporting air enema and 64 reporting liquid enema with 41 292 patients were enrolled.In 75 articles (24 550 patients), the combined success rate of air enema was 88% (95% CI,86%～89%;I
2
=95%), and in 64 articles (16 092 patients) of liquid enema,it was 80% (95%CI,78%～83%;I
2
=96%).In 57 articles (20 290 patients),the combined perforation rate for air enema was 1% (95% CI,1%～1%;I
2
=53%),and in 36 articles (10 486 patients) of liquid enema,it was 1% (95% CI,0%～1%;I
2
=0%).Among 5 430 patients (20 articles) undergoing air enema reduction, the rate of recurrence was 7% (95% CI,5%～9%;I
2
=85%), and in 10 articles (1 792 patients) of liquid enema,it was11% (95% CI,7%～15%;I
2
=71%).
Conclusion
Air enema is superior to liquid enema for intussusception in children. The success rate of air enema is significantly higher than that of liquid enema, and the recurrence rate is significantly lower than that of liquid enema.There is no significant difference in perforation rate.
2019 Vol. 42 (2): 90-95 [
Abstract
] (
259
)
HTML
(1 KB)
PDF
(2251 KB) (
124
)
96
Clinical study of the correlation between HBV-DNA quantification, liver hardness value and hepatitis B cirrhosis with esophageal and gastric varicose endoscopy for early rebleeding
LIU Puhui, LIU Yipin, XU Ning, CAO Xiaoling, LI Xia, JIANG Weiwei, MOU Shaojiao
DOI: 10.19739/j.cnki.issn1001-9510.2019.02.005
Objective
To investigate the clinical value of HBV-DNA quantification and liver stiffness in patients with hepatitis B cirrhosis complicated with esophagogastric variceal bleeding (EVB) after endoscopic treatment.
Methods
Patients with EVB who underwent endoscopic treatment from August 2016 to July 2018 were divided into the bleeding group (27 cases) and the non-bleeding group (201 cases) according to whether early bleeding occurred after treatment.The risk factors that may lead to rebleeding after EVB were assigned,and then Logstic regression analysis was performed to explore the risk factors of rebleeding after EVB.The correlation between HBV-DNA quantification,liver stiffness and prediction of rebleeding after endoscopic therapy was observed by describing the subject work curve (ROC). The specificity and sensitivity of the combined detection were calculated and the value of the combined detection was observed.
Results
(1)Among 228 EVB patients in this study,27 cases had early rebleeding after EVB.The early rebleeding rate after EVB endoscopy was 11.84%.(2)The HBV-DNA content and liver stiffness of patients with early rebleeding were significantly higher than those of patients without bleeding (
P
＜0.01).(3) Logistic regression analysis showed that HBV-DNA, liver stiffness,fasting blood glucose and the number of varices were risk factors for early rebleeding after EVB.(4)ROC curve showed that HBV-DNA content and liver stiffness could significantly improve the sensitivity and specificity of predicting rebleeding after EVB.
Conclusion
HBV DNA quantification and liver stiffness were significantly increased in patients with rebleeding after EVB.HBV DNA quantification and liver stiffness could be used to evaluate the risk of rebleeding after EVB.
2019 Vol. 42 (2): 96-98 [
Abstract
] (
182
)
HTML
(1 KB)
PDF
(986 KB) (
142
)
99
Clinical observation of femtosecond laser small incision lenticule extraction in the treatment of myopia and astigmatism
SU Yue, DING Dongmei, FU MengJun, ZHANG Haorun, ZHANG Shaobin, HUO Lei
DOI: 10.19739/j.cnki.issn1001-9510.2019.02.006
Objective
To observe the clinical effect of femtosecond laser small incision lenticule extraction in the treatment of myopia and astigmatism.
Methods
In the prospective case study,45 cases with 90 eyes received SMILE surgery treatment. The average equivalent spherical mirrors for preoperative was (-4.05±1.36) D. The smile surgeries used 500 KHZ VisuMax femtosecond laser and the energy was 115 nj.The point spacing was 3.0 microns and spot size was 1.5 microns.The micro lens diameter was 6.0 to 6.5 mm. The base thickened was 10 microns and the corneal cap was 6.8 to 7.5 mm in diameter.The thickness of the cap was 130-140 microns and the edge cut was 2 mm with the location of 120 degrees.The changes of the surface curvature before and after operation were observed. The mean follow-up time was 3 months.
Results
All patients achieved or exceeded the best corrected visual acuity before surgery, and none of them lost the best corrected visual acuity.There was a statistically significant difference in vision between 1d postoperative and 1mo postoperative and 3mo postoperative (
P
＜0.05).Comparison of postoperative residual equivalent spherical lens with postoperative 1d, postoperative 1wk, postoperative 1mo and postoperative 3mo could not be considered statistically significant (
P
＞0.05).Comparison between 1d postoperative,1wk postoperative,1mo postoperative and 3 mo postoperative after intraocular pressure cannot be considered statistically significant (
P
＞0.05).There were statistically significant differences between 1d postoperative and 1wk postoperative,1mo postoperative and 3mo postoperative after anterior corneal surface curvature (
P
＜0.05).Comparison of postoperative 1mo and postoperative 3mo on the posterior corneal surface before surgery, 1d after surgery and 1wk after surgery cannot be considered statistically significant (
P
＞0.05).
Conclusion
Femtosecond laser small incision lens removal has good predictability, safety, predictability and stability in the correction of myopia and astigmatism. The corneal remodeling process after SMILE was mainly caused by the changes in the curvature of the anterior surface of the cornea, which reached a stable state about 3 months later.
2019 Vol. 42 (2): 99-101 [
Abstract
] (
183
)
HTML
(1 KB)
PDF
(986 KB) (
192
)
102
Effect of pre-etching time on the marginal microleakage of the V caves after the composite resin filling
HUI Min, MIAO Detian, WANG Xinxin, ZHOU Han, ZHANG Xiaoming
DOI: 10.19739/j.cnki.issn1001-9510.2019.02.007
Objectives
To reduce the time of pre-etching on the basis of preacid etching 15 s,and to study the effect of reducing the preacid etching time on the marginal microleakage of the V caves after the composite resin filling.
Methods
Eighty freshly extracted molar teeth were randomly divided into four groups,20 in each group, which were treated by pre acid etching time 0 s, 3 S, 10 s and 15 s respectively.Then the Results were analyzed with the evaluation criteria of the 0～4 level microleakage.
Results
The microleakage of all pre-etching groups was significantly lower than that of the non pre-etching group,but there was no significant difference in microleakage between different etch groups.
Conclusion
Reducing the time of pre etching can reduce the marginal microleakage of V class cavity after composite resin filling,nothing to do with pre-etching time.Dentists can reduce acid etching time to reduce the adverse effect of acid etching on dentin adhesion.
2019 Vol. 42 (2): 102-105 [
Abstract
] (
116
)
HTML
(1 KB)
PDF
(1134 KB) (
169
)
106
A study on the correlation between migraine and right-to-left shunt by contrast enhanced transcranial Doppler (c-TCD)in the Yellow River Delta region
ZHAO Bin, MA Wenbin, ZHANG Qingqing, LIU Xiangjun, WANG Yueping
DOI: 10.19739/j.cnki.issn1001-9510.2019.02.008
Objective
The association between RLS and migraine is still debated. The aim of this study is to investigate the prevalence and grade of RLS in he Yellow River Delta region patients with migraine and to evaluate the relationship between RLS and migraine.
Methods
Two hundred and sixteen cases of migraine patients and 127 healthy volunteers as control group using contrast enhanced transcranial Doppler ( c-TCD) or diagnosis of RLS and grade the positiverate of the two groups were statistically analyzed.
Results
In the case group,the positive rate of RLS was 47.2%(102 /216).In the control group,the positive rate of RLS was 22.8% ( 29 /127) .Comparison of two groups of the total positive rate,the total positive rate of case group was higher than the control group,there wasstatistically significant difference (
P
＜0.001,
χ
2
= 20.15) . Large shunt rate in case group was significantly higher than thecontrol group (
P
＜0.001,
χ
2
= 21.582) ,but the two groups of small shunt rate had no significant difference (
P
=0.231,
χ
2
=1.430).
Conclusion
This multi-centre case-control study suggested that there is an association between RLS and migraine, especially when the shunt is large.
2019 Vol. 42 (2): 106-109 [
Abstract
] (
180
)
HTML
(1 KB)
PDF
(1000 KB) (
96
)
110
Diagnostic value of routine MRI scan combined with DWI and 3D-ASL in adult medulloblastoma
LIU Songguo, ZHAO Lei, YU Xiuying, HAN Guang, MENG Xiangfu, ZHANG Fuli
DOI: 10.19739/j.cnki.issn1001-9510.2019.02.009
Objective
To evaluate the value of conventional MRI scan combined with DWI and 3D-ASL in the diagnosis of adult posterior fossa medulloblastoma.
Methods
Twelve cases of adult medulloblastoma confirmed by operation and pathology were retrospectively analyzed. All cases underwent conventional and DWI scanning, and 6 cases underwent 3D-ASL scanning.
Results
There were 6 cases in cerebellar hemisphere (50%),3 cases in cerebellar vermis (25%),2 cases in fourth ventricle (16.7%) and 1 case in cerebellopontine angle region (8.3%).MRI showed isointense or slightly low signal on T1WI,isointense or slightly high signal on T2WI and FLAIR,high signal on DWI and low signal on ADC.There were 11 cases of cystic degeneration or necrosis in tumor,1 case of calcification in tumor and 1 case of hemorrhage in tumor.The solid part of most tumors was obvious enhancement.Six cases of ASL showed hypoperfusion,and there was a significant difference between the CBF value of tumor and the CBF value of mirror side (
P
＜0.05).
Conclusion
Conventional MRI combined with DWI and 3D-ASL is of great value in the diagnosis and differential diagnosis of adult posterior fossa medulloblastoma.
2019 Vol. 42 (2): 110-112 [
Abstract
] (
167
)
HTML
(1 KB)
PDF
(1730 KB) (
215
)
113
Study about preparation and release rate in vitro of Potassium chloride wax matrix sustained-release tablets
BAO Yusheng, MA Chong, YUAN Xiaoli, TAO Li YE Hai
DOI: 10.197391j.cnki.issn1001-9510-2019.02.010
Objective
To prepare the wax matrix sustained-release tablets of potassium chloride baseing on the hot-melt extrusion technology,and investigate the in-vitro release consistency between homemade and reference preparation,which will provide eference for domestic enterprises to carry out the consistency evaluation of this product.
Methods
Hydrogenated vegetable oil was used as a wax skeleton material,and Pharma 16 hot-melt extruder was used to prepare a potassium chloride sustained-release tablet by a hot melt granulation process.In addition,an in vitro release curve was examined.
Results
When the amount of hydrogenated vegetable oil was 25%, the release profile was similar to the reference formulation, and the f2 factor in the aqueous medium was 76. The extrudate obtained by the extruding operation with the extrusion temperature parameter setting between 60～65°C had good melting effect.
Conclusion
The main prescription factor affecting on the in vitro release of potassium chloride was the amount of hydrogenated vegetable oil.The main process factor was the size of the granules after the crushed whole extrudate.
2019 Vol. 42 (2): 113-118 [
Abstract
] (
218
)
HTML
(1 KB)
PDF
(1537 KB) (
169
)
119
Study on the effects of hawthorn proanthocyanidins on anti-oxidation,removing nitrite and inhibiting nitrosamine synthesis
MI Wei, HAN Lizhen, HAN Fulei, ZHANG Hongping, JIANG Wei LI Wenyang, YANG Linghua, HUANG Xuzhao, TIAN Lijun
DOI: 10.197391j.cnki.issn1001-9510.2019.02.011
Objective
To study the effects of hawthorn procyanidins (HPC) on anti-oxidation, removing nitrite,and blocking the synthesis of nitrosamines.
Methods
HPC and vitamin C concentrations were 20mg / L,80mg / L,140mg / L,200mg /L, 260mg /L, 320mg /L.Spectrophotometer was used in the HPC group to measure the ability to remove superoxide anion radicals(O
-
2·
), hydroxyl radicals(·OH),and DPPH·,the ability of total antioxidant capacity,and the ability to remove nitrite and block nitrosamine synthesis, and the Results were compared between the two groups.
Results
The hydroxyl free radical(·OH)scavenging rate of HPC group was significantly higher than that of vitamin C group (
P
＜0.05) in the concentration range from 20mg/L to 260 mg/L.Under the setting concentration range,the DPPH free radical scavenging and total antioxidant capacity of HPC group were higher than those of vitamin C group (
P
＜0.05),And its free radical scavenging capacity and total antioxidant capacity were proportional to the concentration.HPC showed strong scavenging capacity against nitrite, and the scavenging capacity increased with the increasing concentration in the range of test concentration. In the range from 140mg/L to 320 mg/L, the scavenging rate of HPC for nitrite was higher than that of vitamin C group (
P
＜0.05).
Conclusion
HPC has a strong anti-oxidant effect, can effectively remove nitrite and block the synthesis of nitrosamines, and has a positive effect on the body's anti-aging and cancer prevention.
2019 Vol. 42 (2): 119-122 [
Abstract
] (
211
)
HTML
(1 KB)
PDF
(1363 KB) (
141
)
123
The effect of continuing nursing based on Omaha system on PICC outcomes in tumor patients
MA Zhenzhen, WANG Yujie, ZHOU Jing, WANG Xiaoxiao, ZHANG Min, LUAN Shunlian, XU Hongmei
DOI: 10.19739/j.cnki.issn1001-9510.2019.02.012
Objective
To explore the inflence of continuous care based on the Omaha system on PICC care outcomes in tumor patients.
Methods
From February to December 2017,46 patients with PICC catheters were selected as the control group and adopted the routine nursing model.Fifty patients were selected as experimental group and carried out the continuation of nursing based on the Omaha system.The cognition, behavior, and status of patients'nursing problems were evaluated,and the improvement of nursing outcomes in the two groups was compared at the first time the catheters placed in, the first time of chemotherapy, second chemotherapy and the third of chemotherapy.
Results
Seventeen nursing issues of two groups of patients in the cognition, behavior, status in the field of environmental, psychosocial, physiological, health-related behavioral are growing with the evaluation time and time effect between the difference had statistical significance (
P
＜0.05) Patients in the experimental group have higher scores than that in the control group in the area of cognition,behavior,status in the fields of community resources,social,mental health,neglect,cognition,pain,skin, neuromuscular,circulation,infection,personal care,health care supervision,compliance issues and Income,health problem cognition,role change,physical activity problem cognition,behavioral dimension.There was a statistically significant difference between the groups (
P
＜0.05).However, the scores of income,health problems,status,role changes and physical activity problems were higher than those in the control group,but the difference between the groups was not statistically significant (
P
＞0.05).
Conclusion
The continuing nursing based on Omaha system can improve the cognition,behavior and status of PICC environment,psychosocial,physiological and health-related behaviors of tumor patients,improve nursing outcomes comprehensively,and achieve better nursing results.
2019 Vol. 42 (2): 123-129 [
Abstract
] (
152
)
HTML
(1 KB)
PDF
(1060 KB) (
78
)
Copyright © Editorial Board of 滨州医学院学报
Supported by:
Beijing Magtech
