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Analysis of the characteristics of hospitalized patients with systemic lupus erythematosus in the Yellow River Delta |
GE Fengmei, YAN Xiuqing, WANG Fangfang, WANG Xinyun, SHI Fang, WANG Xuebin |
Department of Rheumatology and Immunology,Binzhou Medical University Hospital, Binzhou 256603,P.R.China |
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Abstract Objective To analyze the clinical characteristics,treatment and progonsis of hospitalized patients with systemic lupus erythematosus (SLE) in the Yellow River Delta.Methods The clinical characteristics,laboratory test,pathology and therapeutic regimen of 351 cases with SLE were retrospectively analyzed.Results The ratio of male and female was 1∶10.7. The most common clinical symptoms was joint pain, which accounted for 41%,and followed by fever accounted for 35%, rash accounted for 30%,swelling accounted for 10%,fatigue accounted for 9%.Kidney was the most commonly affected organ, the largest number of pathological types was type Ⅳ lupus nephritis.Total mortality of patients was 2.2%, and the death in patients with infection accounted for 1.4%.Conclusion SLE primarily occurs in childbearing aged women,and its clinical presentation is complex and varied.Preventing the infection can improve the prognosis of SLE.
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Received: 19 June 2018
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[1] 中华医学会风湿病学分会.系统性红斑狼疮诊断及治疗指南[J].中华风湿病学杂志,2010,14(3):342-346. [2] Chung S A,Taylor K E,Graham R R,et al.Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production[J].PLoS Genet,2011,7(3):e1001323. [3] Tan E M,Cohen A S,Fries J F,et al.The 1982 revised criteria for the classification of systemic lupus erythematosus[J].Arthritis Rheum,1982,25(11):1271-1277. [4] Hochberg M C.Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus[J].Arthritis Rheum,1997,40(9):1725. [5] Walker S E.Estrogen and autoimmune disease[J].Clin Rev Allergy Immunol,2011,40(1):60-65. [6] Ray A,Ficek M.Immunomodulatory effects of anti-estrogenic drugs[J].Acta Pharm,2012,62(1):141-155. [7] Kisiel B M,Kosinska J,Wierzbowska M,et al.Differential association of juvenile and adult systemic lupus erythematosus with genetic variants of oestrogen receptors alpha and beta[J].Lupus,2011,20(1):85-89. [8] Svenson J L,EuDaly J,Ruiz P,et al.Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse[J].Clin Immunol,2008,128(2):259-268. [9] Zhu X,Xu J,Li S,et al.Role of abnormal anterior pituitary hormones-growth hormone and prolactin in active systemic lupus erythematosus[J].Int J Clin Exp Med,2015,8(10):19223-19231. [10] Li M,Zhang W,Leng X,et al.Chinese SLE Treatment and Research group (CSTAR) registry: I.Major clinical characteristics of Chinese patients with systemic lupus erythematosus[J].Lupus,2013,22(11):1192-1199. [11] Berden J H. Lupus nephritis[J].Kidney Int,1997,52(2):538-558. [12] Shen Y,Sun C Y,Wu F X,et al.Association of intrarenal B-cell infiltrates with clinical outcome in lupus nephritis: a study of 192 cases[J].Clin Dev Immunol,2012:967584. [13] Agmon-Levin N,Damoiseaux J,Kallenberg C,et al.International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies[J].Ann Rheum Dis,2014,73(1):17-23. [14] Linnik M D,Hu J Z,Heilbrunn K R,et al.Relationship between anti-double-stranded DNA antibodies and exacerbation of renal disease in patients with systemic lupus erythematosus[J].Arthritis Rheum,2005,52(4):1129-1137. [15] Olsen N J,Schleich M A,Karp D R.Multifaceted effects of hydroxychloroquine in human disease [J].Semin Arthritis Rheum,2013,43(2):264-272. [16] D'Cruz D P,Khamashta M A,Hughes G R.Systemic lupus erythematosus[J].Lancet,2007,369(9561):587-596. [17] Feldman C H,Hiraki L T,Winkelmayer W C,et al.Serious infections among adult Medicaid beneficiaries with systemic lupus erythematosus and lupus nephritis[J].Arthritis Rheumatol,2015,67(6):1577-1585. |
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