|
|
|
| Expression and the clinical significance of SCIN in ovarian cancer |
| MENG Xuan1, HOU Jianqing2 |
1 School of Medicine,Qingdao University,Qingdao 266000,P.R.China;
2 Department of Gynaecology and Obstetrics, QingDao University Affiliated Yantai Yuhuangding Hospital |
|
|
|
|
Abstract Objective To investigate the expression and the clinical significance of SCIN in epithelial ovarian cancer.Methods Immunohistochemistry assay and western blot were used to detect the expression of SCIN in epithelial ovarian cancer tissues and normal ovarian tissues.Results The expression of SCIN in epithelial ovarian cancer tissues was significantly higher than that in normal ovarian tissues, and there was statistical significance between the two groups. The expression of SCIN was correlated with the clinical stage, grade of differentiation, lymph node metastasis and pritoneal seeding, while it is not correlated with age. The gray level of SCIN in epithelial ovarian cancer cells was significantly higher than that in normal ovarian cells, and there was statistical significance between the two groups.Conclusion The expression level of SCIN in epithelial ovarian cancer tissues is high, which indicates that it may participate in the occurrence and development of ovarian cancer, and it may become a tumor marker for clinical early diagnosis and a new target gene for treatment of ovarian cancer.
|
|
Received: 10 September 2018
|
|
|
|
|
|
[1] Lejen T,Pene T D,Rosé S ,et al.The role of different Scinderin domains in the control of F-actin cytoskeleton during exocytosis[J].Ann N Y Acad Sci,2002,971(1):248-250.
[2] Liu J J, Liu J Y,Chen J,et al.Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients[J].Cancer Letters,2016,376(1):110-117.
[3] Guillou H,Depraz-Depland A,Planus E,et al.Lamellipodia nucleation by filopodia depends on integrin occupancy and downstream Rac1 signaling[J].Exp Cell Res,2008,314(3):478-488.
[4] Wang D,Sun S Q,Yu Y H,et al.Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest[J].International Journal of Oncology,2014,44(1):161-166.
[5] Vantaku V,Donepudi S R,Ambati C R,et al.Expression of ganglioside GD2,reprogram the lipid metabolism and EMT phenotype in bladder cancer[J].Oncotarget,2017,8(56):95620-95631.
[6] Sweeney J B,Murphy C D,Mcdonnell K.Development of a bacterial propionate-biosensor for anaerobic digestion monitoring[J].Enzyme Microb Technol,2018,109:51-57.
[7] Mody H R, Hung S W,Naidu K,et al.SET contributes to the epithelial-mesenchymal transition of pancreatic cancer[J].Oncotarget,2017,8(40):67966-67979.
[8] Wieczorek K,Wiktorska M,Sacewicz-Hofman I,et al.Filamin A upregulation correlates with Snail-induced epithelial to mesenchymal transition (EMT) and cell adhesion but its inhibition increases the migration of colon adenocarcinoma HT29 cells[J].Experimental Cell Research,2017,359(1):163.
[9] Gurzu S,Banias L,Bara T,et al.The Epithelial-Mesenchymal Transition Pathway in Two Cases with Gastric Metastasis Originating from Breast Carcinoma, One with a Metachronous Primary Gastric Cancer[J].Recent Pat Anticancer Drug Discov,2018,13(1):118-124.
[10] Lee H K,Lee D S,Park J C.Nuclear factor I-C regulates E-cadherin via control of KLF4 in breast cancer[J].BMC Cancer, 2015,15(1):1-11.
[11] Nowrin K,Sohal S S,Peterson G,et al.Epithelial-mesenchymal transition as a fundamental underlying pathogenic process in COPD airways:fibrosis,remodeling and cancer[J].Expert Review of Respiratory Medicine,2014,8(5):547.
[12] Chen X M,Guo J M,Chen P,et al.Suppression of scinderin modulates epithelialmesenchymal transition markers in highly metastatic gastric cancer cell line SGC7901[J].Molecular Medicine Reports,2014,10(5):2327.
[13] Dinicola S,Fabrizi G,Masiello M G,et al. Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement[J].Experimental Cell Research,2016,345(1):37-50.
[14] Anastas J N,Moon R T.WNT signalling pathways as therapeutic targets in cancer[J].Nature Reviews Cancer,2013,13(1):11-26.
[15] Hasmim M,Badoual C,Vielh P,et al.Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells[J].Bmc Cancer,2013,13(1):592.
[16] Lejen T,Pene T D,Rosé S D,et al.The role of different Scinderin domains in the control of F-actin during exocytosis[J].Annals of the New York Academy of Sciences,2002,971(1):248-250.
[17] Agarwal N,Adhikari A S,Iyer S V,et al.MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4[J].Oncogene,2013,32(4):462-470.
[18]Li Y,Zhang Z,Zhou X,et al.The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling[J].Cancer Letters,2014,355(2):288-296. |
|
|
|
