聚己内酯/纳米羟基磷灰石静电纺纤维膜的制备及其生物活性

doi:10.19739/j.cnki.issn1001-9510.2021.04.012

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Abstract Objective To study the physical-chemical characteristics, biological properties and osteogenic activity of the polycaprolactone/nano-hydroxyapatite composite materials prepared by electrospinning technology.Methods The electrospinning technology was used to fabricate the polycaprolactone/nano-hydroxyapatite composite material, and the physical and chemical characterization were measured. And then MC3T3-E1 cells were used as the model to evaluate the biocompatibility and osteogenic activity of the composite material in order to provide experimental basis for its application in guided bone regeneration.Results The polycaprolactone/nano-hydroxyapatite composite material with a disordered non-woven three-dimensional staggered network structure can show low tensile strength and good wettability. MC3T3-E1 cells with pseudopodia can grow well on the polycaprolactone/nano hydroxyapatite membrane, which could promote the expression of alkaline phosphatase and Runx2 gene.Conclusion The polycaprolactone/nano hydroxyapatite electrospun membrane could show good physical-chemical characteristics, biological properties and osteogenic properties, which was a potential material for bone regeneration.

Key words： polycaprolactone electrospinning nano hydroxyapatite MC3T3-E1 cell bioactivity

Received: 28 December 2020

PACS:

R783.1

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	Articles by authors
	LI Yourui
	ZHANG Zihan
	XIONG Shijiang
	SONG Hualei

Cite this article:

LI Yourui,ZHANG Zihan,XIONG Shijiang, et al. Preparation and bioactivity of polycaprolactone/nano hydroxyapatite electrospun fiber membrane[J]. 滨州医学院学报, 2021, 44(4): 287-291.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2021.04.012 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2021/V44/I4/287

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