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Analysis of pregnancy outcome after multifetal pregnancy reduction under the guidance of transvaginal ultrasound |
LAO Kaixue, DIAO Xinghua, ZHAI Qingliang, MA He, ZHANG Dongmei, YUAN Saisai, DING Peihui, WANG Yanlin* |
Reproductive Medicine Center, Binzhou Medical University Hospital, Binzhou 256003, Shandong, P. R. China |
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Abstract Objective To analyze the pregnancy outcome of patients undergoing multiple pregnancy reduction.Methods Retrospective analysis was carried out on clinical data of 63 pregnant women with multiple pregnancies through transvaginal fetal reduction. The patients were divided into four groups: four fetuses reduced to twins group, three fetuses reduced to twins group, three fetuses reduced to singles group, and twins reduced to singles group. The pregnancy outcome of patients in each group after pregnancy reduction was analyzed.Results Of the 63 patients undergoing fetal reduction, 50 had a successful delivery, 3 had early miscarriage (4.67%), 9 had late miscarriage (14.29%), 1 had induced labor due to fetal cleft lip, and 37 had full-term labor (58.73%), 13 cases of premature delivery (20.63%), and the rate of low birth weight infants was 43.53%. There was no statistically significant difference between the two groups reduced to twins and the two groups reduced to singles in early abortion, premature delivery, neonatal weight, and low-birth-weight infants. Compared with the multiple fetuses reduced to singles, the multiple fetuses reduced to twins groups had lower birth weight, and the difference was statistically significant. There was no statistical difference between the groups in the early abortion rate, late miscarriage rate, premature birth rate, and low birth weight rate.Conclusion Pregnancy outcomes after multiple pregnancy reduction are mostly related to the final number of pregnancy, but not related to the number of initial pregnancy sacs. The multiple fetuses reduced to twins groups have higher complications than reduction to singles, so it is recommended that multiple pregnancy reduction be better to single pregnancy
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Received: 21 October 2020
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[1] SUNDERAM S, KISSIN D M, CRAWFOED S, et al. Assist reproductive technology surveillance-United States, 2013[J].MMWR Surveill Summ, 2015, 64(11): 1-25. [2] MARTIN J A, HAMILTON B E, VENTURA S J, et al. Births: final date for 2010[J]. Natl Vital Stat Rep, 2012, 61(1); 1-72. [3] The ESHRE Capri Workshop Group. Multiple gestation pregnancy[J]. Hum Reprod, 2000,15(8): 1856-1864. [4] 胡琳莉,黄国宁,孙海翔,等.多胎妊娠减胎术操作规范(2016)[J].生殖医学杂志,2017,26(3):193-198. [5] ANTHOULAKIS C, DAGKLIS T, MAMOPOULOS A, et al. Risks of miscarriage or preterm delivery in trichorionic and dichorionic triplet pregnancies with embryo reduction versus expectant management: a systematic review and meta-analysis[J]. Hum Reprod, 2017, 32(6): 1351-1359. [6] 白云,马艳萍. 多胎妊娠减胎术发展现状[J]. 中华生殖与避孕杂志, 2017, 37(3): 245-149. [7] LIU R, ZHANG C, SHI Y, et al. Dysbiosis of gut microbiota associated with clinical parameters in polycystic ovary syndrome[J]. Front Microbiol, 2017, 8: 324. [8] 张庆颜,陈士岭,周星宇,等.全面二孩政策下多胎妊娠减胎术55例临床结局分析[J].实用医学杂志,2019,35(14):2243-2245. [9] 孟庆霞,吴惠华,李建芬,等.选择性减胎术可以明显改善多胎妊娠的临床妊娠结局[J]. 生殖医学杂志,2017,26(10):1035-1040. [10] DODD J M, DOWSWELL T, CROWTHER C A. Reduction of the number of fetuses for women with a multiple pregnancy[J]. Cochrane Database Syst Rev, 2015, 4(11): CD003932. [11] STONE J, FERRARA L, KAMRATH J, et al. Contemporary outcomes with the latest 1000 cases of multifetal pregnancy reduction (MPR) [J]. Am J Obstet Gynecol, 2008,199(4): 406. [12] DICKEY R P, TAYLOR S N, LU P Y, et al. Spontaneous reduction of multiple pregnancy: Incidence and effect on outcome[J]. Am J Obstet Gynecol,2002,186(1):77-83. [13] BHANDARI S, GANGULY I, AGRAWAL P, et al. Comparative analysis of perinatal outcome of spontaneous pregnancy reduction and multifetal pregnancy reduction in triplet pregnancies conceived after assisted reproductive technique[J]. J Hum Reprod Sci,2016,9(3):173-178. [14] SALEM I, RAMSER A, ISHAM N, et al. The gut microbiome as a major regulator of the gut-skin axis[J]. Front Microbiol, 2018, 9: 1459. [15] SPITTLE A, ORTON J, ANDERSON P, et al. Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants[J]. Cocharane Database Syst Rev, 2015, 24(11): CD005495. [16] 何春,付士强,罗函渝,等.早期综合干预对早产低体重儿体格发育和智力发展的影响分析[J].中国妇幼保健,2016,31(5):976-978. [17] 刘凤华,杨业洲,张松英,等.辅助生殖技术并发症诊断及处理共识[J].生殖与避孕,2015,35(7):431-439. [18] 徐冰,路遥,何亚琼,等.多胎减胎后单胎分娩与单胎妊娠分娩比较分析[J].中华生殖与避孕杂志,2017,37(6):485-488. [19] NORWITZ E R, EDUSA V, PARK J S. Maternal physiology and complications of multiple pregnancy[J]. Semin Perinatol, 2005, 29(5): 338-348. [20] 李佳美,何玉洁.多胎妊娠患者124例减胎术后妊娠结局的分析[J].医学综述,2020(1):196-199. |
[1] |
JI Shanshan. Effects of gasbag midwifery assisted vaginal delivery on labor process and pregnancy outcomes of puerperae with scarred uterus and previous history of cesarean section[J]. 滨州医学院学报, 2020, 43(3): 206-208. |
[2] |
ZHOU Xuegui, YUAN Jiang, XUE Guige. Retrospective analysis of pregnancy risk in the advanced maternal age[J]. 滨州医学院学报, 2020, 43(2): 118-121. |
[3] |
. [J]. 滨州医学院学报, 2019, 42(4): 318-319. |
[4] |
. [J]. 滨州医学院学报, 2018, 41(3): 235-237. |
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