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Analysis of risk factors related to the progression of brain stem infarction |
GENG Yanlei, SONG Xiaowen, ZHUANG Wei, CHEN Jinbo* |
Department of Neurology, Binzhou Medical University Hospital, Binzhou 256603, Shandong, P. R. China |
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Abstract Objective To explore the risk factors for the progression of brainstem infarction.Methods Totally 173 patients with confirmed brainstem infarction were selected and divided into two groups: the progressive group and the unprogressive group. The risk factors of the two groups were compared and multivariate logistic regression analysis was performed.Results Compared with those in the non-progressive group, the proportion of smoking history, diabetes history, fever, unstable plaque, severe vascular stenosis, medulla oblongata infarction and LDL level in the progressive group significantly increased, while the proportion of midbrain infarction significantly decreased (all P<0.05). Multivariate logistic regression analysis showed that smoking history, diabetes history, fever, unstable plaque, severe vascular stenosis and medulla oblongata infarction were independent risk factors for the progression of brainstem infarction, while LDL and midbrain infarction were not associated with the progression of brainstem infarction.Conclusion Smoking history, diabetes history, fever, unstable plaque, severe vascular stenosis and medulla oblongata infarction are independent risk factors for the progression of brainstem infarction, which can significantly predict the progression of brainstem infarction. Timely identification of the above risk factors and effective intervention may prevent the aggravation of patients with brainstem infarction.
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Received: 06 April 2021
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[1] OHKI M, TANAKA K. An isolated vestibulocochlear symptom preceding brainstem infarction due to basilar artery occlusion[J]. Otol Neurotol, 2012,33(5):730-732. [2] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682. [3] BIRSCHEL P, ELLUL J, BARER D. Progressing stroke: towards an internationally agreed definition[J]. Cerebrovasc Dis, 2004,17(2-3):242-252. [4] NORTH AMERICAN SYMPTOMATIC CAROTID ENDARTERECTOMY TRIAL COLLABORATORS, BARNETT H J M, TAYLOR D W, et al. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis[J]. N Engl J Med, 1991,325(7):445-453. [5] PAN B, JIN X, JUN L, et al. The relationship between smoking and stroke: a meta-analysis[J]. Medicine (Baltimore), 2019,98(12):14872. [6] AMBROSE J A, BARUA R S. The pathophysiology of cigarette smoking and cardiovascular disease: an update[J]. J Am Coll Cardiol, 2004,43(10):1731-1737. [7] MANDRAFFINO G, ARAGONA C O, SCURUCHI M, et al. Biglycan expression, earlier vascular damage and pro-atherogenic profile improvement after smoke cessation in young people[J]. Atherosclerosis, 2017,257(1):109-115. [8] KASHIWAGI H, YUHKI K I, IMAMICHI Y, et al. Cigarette smoke extract inhibits platelet aggregation by suppressing cyclooxygenase activity[J]. TH Open, 2017,1(2):122-129. [9] GUM PA, KOTTKE-MARCHAND K, POGGIO E D, et al. Profile and prevalence of aspirin resistance in patients with cardiovascular disease[J]. Am J Cardiol,2001, 88(2):230-235. [10] FERRARI J, KNOFLACH M, KIECHL S, et al. Early clinical worsening in patients with TIA or minor stroke: the austrian stroke unit registry[J]. Neurology, 2010,74(2):136-141. [11] EXHENRY C, REGLI F, BOGOUSSLAVSKY J, et al. Prognosis in brain stem infarction [J]. Rev Med Suisse Romande, 1992,112(6):539-546. [12] 陆正齐,李海燕,胡学强,等.脑干梗死合并糖尿病的临床特点及预后分析[J].中华内科杂志,2011,50(1):27-30. [13] 许文灿,陈慎仁,陈永松.糖尿病并脑梗死的发病及预后影响因素分析[J].中国综合临床,2001,17(1):42-43. [14] REITH J, JØRGENSEN H S, PEDERSEN P M, et al. Body temperature in acute stroke: relations to stroke severity, infarct size, mortality, and outcome[J]. Lancet,1996, 347(3):422-425. [15] DÁVALOS A, CASTILLO J, PUMAR J M, et al. Body temperature and fibrinogen are related to early neurological deterioration in acute ischemic stroke[J]. Cerebrovasc Dis,1997, 7(1):64-69. [16] DIETRICH W D. Temperature changes and ischemic stroke. In:Fischer M,Bogousslavsky J,eds. Current Review of Cerebrovascular Diseases[M]. 2cond ed. Philadelphia: Current Medicine,1996: 43-52. [17] SAVITZ S I, CAPLAN L R. Vertebrobasilar disease[J]. N Engl J Med, 2005,352(25):2618-2626. [18] GULLI G, MARQUARDT L, ROTHWELL P M, et al. Stroke risk after posterior circulation stroke/transient ischemic attack and its relationship to site of vertebrobasilar stenosis: pooled data analysis from prospective studies[J]. Stroke, 2013,44(3):598-604. [19] MARQUARDT L, KUKER W, CHANDRATHEVA A, et al. Incidence and prognosis of >or=50% symptomatic vertebral or basilar artery stenosis: prospective population-based study[J]. Brain,2009,132(4):982-988. [20] GULLI G, KHAN S, MARKUS H S. Vertebrobasilar stenosis predicts high early recurrent stroke risk in posterior circulation stroke and TIA[J]. Stroke, 2009,40(8):2732-2737. [21] GÖKÇAL E, BARAN G, NIFTALIYEV E, et al. Risk factors, etiological classification, topographical location, and outcome in medullary infarctions[J]. Neurologist,2017,22(4):116-119. [22] HATA Y, YOSHIDA K, KINOSHITA K, et al. Sudden unexpected death owing to unilateral medial medullary infarction with early involvement of the respiratory center[J] . Leg Med (Tokyo) , 2014, 16(3): 146-149. [23] MARTINO R, FOLEY N, BHOGAL S, et al. Dysphagia after stroke: incidence, diagnosis, and pulmonary complications[J]. Stroke, 2005, 36(12):2756-2763. [24] AYDOGDU I, ERTEKIN C, TARLACI S, et al. Dysphagia in lateral medullary infarction (Wallenberg′s syndrome): an acute disconnection syndrome in premotor neurons related to swallowing activity[J]. Stroke, 2001, 32(9):2081-2087. [25] PAVI Č K, PRETNAR-OBLAK J, BAJROVIC′ F F, et al. Prospective study of sleep-disordered breathing in 28 patients with acute unilateral lateral medullary infarction[J]. Sleep Breath, 2020,24(4):1557-1563. |
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