|
|
|
| Optimization of extraction process for volatile oil from compound Corydalismicroemulsiongel cataplasmaby central composite design-response surface methodology |
| GAO Junling1, WANG Huikai2, WANG Bin3, WANG Zhenwei3, LI Xinxin3, GONG Kaikai3, HUANG Yingjie1, MAN Yuqing1,3,*, LI Yan3,* |
1 College of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, P. R. China;
2 Binzhou Traditional Chinese Medicine Hospital, Binzhou 256600, Shandong, P. R. China;
3 Pharmaceutical Department, Binzhou Medical University Hospital, Binzhou 256603, Shandong, P. R. China |
|
|
|
|
Abstract Objective To optimize the extracting condition of volatile oil by central composite design-response surface methodology.Methods Analytical method was established, and volatile oil was extracted by the method of steam distillation. Yield of water, soaking time and extracting time were selected as study factors. The extraction rate of volatile oil, the content of ligustilide and cinnamaldehyde was as the optimized index to abtain the optimal extraction for verifying tests.Results The optimal extracting process was as follows: adding10 times of water, soaking for 100 minutes and extraction time was 8 hours. The expected extraction rate of volatile oil was 0.413%, the content of ligustilide was 39.20%, and cinnamaldehyde was 23.30%. The error between the actual value and the predicted value was less than 0.05.Conclusion The central composite design-response surface methodology has a high accuracy in the extraction of volatile oil, and the parameters are reasonable and reliable.
|
|
Received: 18 December 2020
|
|
|
|
|
|
[1] 赵静,夏晓培.当归的化学成分及药理作用研究现状[J].临床合理用药杂志,2020,13(6):172-174.
[2] 夏天卫,周国威,姚晨,等.桂枝及肉桂治痹的中医认识与现代药学研究进展[J].中国实验方剂学杂志,2019,25(6):218-226.
[3] QADIR M M F, BHATTI A, ASHRAF M U, et al. Immunomodulatory and therapeutic role of Cinnamomum verum extracts in collagen-induced arthritic BALB/c mice[J]. Inflammopharmacology, 2018, 26(1):157-170.
[4] 梁宇飞,张欣欣,许洁,等.星点设计-效应面法优化姜黄素-胡椒碱聚合物复方胶束的处方工艺研究[J].中草药,2020,51(1):43-50.
[5] 国家药典委员会.中华人民共和国药典.四部[M].北京:中国医药科技出版社,2020:223.
[6] 胡杰,冯丽莉,刘延,等.当归、川芎中藁本内酯含量测定及醇提工艺研究[J].沈阳药科大学学报,2005,22(2):145-148.
[7] 强皎,叶炳皇,林丽,等.丁香酚、桂皮醛不同存在状态下的稳定性影响因素研究[J].中药新药与临床药理,2014,25(1):89-92.
[8] 钟立甲,张文泉,华永丽,等.代谢组学方法评价当归不同炮制品挥发油抗大鼠急性炎症作用的研究[J].中国中药杂志,2016,41(11):2061-2069.
[9] 徐锋,王德健,王凤,等.桂枝挥发油的药理作用研究进展[J].中华中医药杂志,2016,31(11):4653-4657. |
| [1] |
LI Na, LI Jinlian, LIU Yuling, LUAN Haiyun. Study on antioxidant capacity of paeonia extract[J]. 滨州医学院学报, 2020, 43(5): 373-376. |
| [2] |
LI Yan, WANG Bin, ZHANG Jinjie, HE Jing, WANG Zhenzhen. The preparation and quality control of Leukoplakia Cream (Ι)[J]. 滨州医学院学报, 2018, 41(4): 289-291. |
| [3] |
LI Xinxin, BO Mingxiang, WANG Zhenzhen, HU Limin, WANG Yu, FAN Qizhong. Preparation and quality control of compound spironolactone gel[J]. 滨州医学院学报, 2018, 41(3): 204-207. |
|
|
|
|
