瞬时弹性成像联合NLR、PLR对乙型肝炎肝硬化并发症的预测价值及与病情严重程度的关系

doi:10.19739/j.cnki.issn1001-9510.2021.03.002

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Abstract Objective To explore the application value of transient elastography combined with neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in predicting the complications of hepatitis B cirrhosis, and to study the relationship between the above indicators and the severity of hepatitis B liver cirrhosis.Methods Retrospective analysis was conducted on 76 patients with hepatitis B liver cirrhosis who were diagnosed in the Binzhou Medical University Hospital from January 2018 to September 2020, and it is divided into CPT A, CPT B, CPT C according to the Child-Pugh (CPT) score; at the same time, it is divided into ≤9 group and ≥10 group according to MELD score; according to the presence or absence of complications, 76 patients with hepatitis B liver cirrhosis were divided into the complication group and the non-complication group; and according to the number of complications, the complication group was divided into the single complication group and the multiple complication group. The changes of NLR, PLR and liver hardness value (LSM) among the groups were compared and analyzed, and the correlation between each index and CPT score and MELD score was further analyzed, and the strength and significance of the correlation were evaluated. Finally, the ROC curve was used to analyze whether each index and the combined application had predictive value for the complications of hepatitis B liver cirrhosis.Results NLR and LSM were positively correlated with CPT score and MELD score, and PLR was negatively correlated with CPT score and MELD score. The NLR and LSM of the complicationgroup were higher than those of the non-complication group, and the PLR was lower than that of the non-complication group. The NLR and LSM of the single complication group were lower than those of the multiple complication group, and the PLR was higher than that of the multiple complication group. The predictive value of NLR, PLR, LSM, NLR combined with PLR, NLR combined with LSM, PLR combined with LSM were expressed by AUC as 0.715, 0.691, 0.777, 0.770, 0.811, 0.830, and 0.839, respectively, where the best cut-off values for NLR, PLR, and LSM were 2.101, 76.92, and 19.3 respectively.Conclusion 1. NLR, PLR, LSM are all related to the severity of hepatitis B liver cirrhosis, and can be used to assess the severity of liver cirrhosis. 2. NLR and LSM are positively correlated and PLR is negatively correlated with the severity of liver cirrhosis. 3. NLR, PLR, LSM, the combination of two and the combination of the three have certain predictive value for the complications of liver cirrhosis, and the combination of NLR, PLR and LSM has the best predictive value for the complications of liver cirrhosis.

Key words： hepatitis B cirrhosis transient elastography CPT score MELD score serological indicator

Received: 23 February 2021

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R575.1

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	HE Yanyan
	LIU Yipin

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HE Yanyan,LIU Yipin. Predictive value of transient elastography combined with NLR and PLR for the complications of hepatitis B liver cirrhosis and its relationship with the severity of the disease[J]. 滨州医学院学报, 2021, 44(3): 167-172.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2021.03.002 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2021/V44/I3/167

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