长链非编码RNA GASL1在脓毒症患者中的表达及其诊断意义

doi:10.19739/j.cnki.issn1001-9510.2021.02.007

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Abstract Objective To analyze the diagnostic value of blood GASL1 in patients with sepsis by collecting and detecting the difference of GASL1 expression between patients with sepsis and patients in the control group.Methods Two hundred and fourteen patients were enrolled, 134 patients with sepsis and 80 patients without sepsis, and 120 healthy people were enrolled. The blood samples of patients were collected within 24 hours after admission. RT-PCR was used to detect the expression level of GASL1.Results The relative expression levels of LncRNAGASL1 were 5.33±4.08, 2.01±1.75 and 1.72±1.40 in sepsis patients, non sepsis patients and healthy trontrols, respectively. The relative expression level of GASL1 in the blood of sepsis patients was significantly higher than that of non sepsis patients (P<0.05) and healthy controls (P<0.05). Compared with the healthy controls, the area under curve (AUC), sensitivity and specificity of blood GASL1 in the diagnosis of sepsis were 0.866, 0.885 and 0.735, respectively. Compared with non sepsis patients, the AUC, sensitivity and specificity of blood GASL1 were 0.861, 0.695 and 0.900. The relative expression level of blood GASL1 in sepsis patients with Apache>15 and sofa>7 was significantly higher than that in sepsis patients with Apache≤15 and sofa ≤ 7, average P<0.05; the relative expression level of GASL1 in sepsis patients was significantly lower than that in severe sepsis and septic shock patients, P<0.05.Conclusion The expression level of GASL1 is increased in patients with sepsis, and it has a better diagnostic value for sepsis.

Key words： sepsis GASL1 APACHEⅡ SOFA

Received: 03 July 2020

PACS:

R459.7

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	ZHANG Weiwei
	LIU Jinqian
	ZHANG Quanyi

Cite this article:

ZHANG Weiwei,LIU Jinqian,ZHANG Quanyi. Expression and clinical significance of LncRNAGASL1 in patients with sepsis[J]. 滨州医学院学报, 2021, 44(2): 108-111.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2021.02.007 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2021/V44/I2/108

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