血管内皮生长因子与急性硬膜外血肿严重程度的关系

doi:10.19739/j.cnki.issn1001-9510.2021.02.004

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Abstract Objective To detect the expression of vascular endothelial growth factor (VEGF) in the blood of patients with acute epidural hematoma (EDH) and explore its relationship with severity.Methods Three hundred and forty-two adult patients admitted to the hospital with EDH whose VEGF values were detected were selected for research. Patients were divided into low,normal and high groups according to the VEGF values detected at admission. New injury severity score (NISS), Glasgow Coma Scale (GCS), hematoma volume, and midline shift were recorded at admission. Early neurological decline (END), surgical procedure, death toll, intensive care unit (ICU) and total hospital stay were recorded at discharge. Pearson correlation analysis was used to analyze the relationship between VEGF levels and various indicators among different VEGF groups. The relationship between VEGF levels and mortality was calculated by analysis of variance. Unconditional logistic regression analysis was used to determine the risk factors associated with mortality.Results Totally 342 patients with EDH were studied, and the mean VEGF at admission was (74.585±37.686) pg/mL. One hundred and forty-seven patients (43.0%) underwent surgery. Sixteen patients (4.7%) died before discharge. Pearson method showed no correlation between VEGF and each index. Analysis of variance showed statistically significant correlation between VEGF reduction and mortality (P<0.05). Logistic regression analysis showed that NISS increase and GCS decrease at admission and VEGF reduction were risk factors associated with mortality.Conclusion In the early phase of admission, the serum VEGF values of more patients with EDH increased, and a few cases decreased. NISS increase, GCS decrease and VEGF reduction during admission were risk factors for mortality.

Key words： vascular endothelial growth factor epidural hematoma mortality Glasgow Coma Scale

Received: 13 August 2020

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R641

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	Articles by authors
	SUN Shengfang
	LI Mintao
	MA Huili
	JIA Zhuting

Cite this article:

SUN Shengfang,LI Mintao,MA Huili, et al. Relationship between VEGF and severity of acute epidural hematoma[J]. 滨州医学院学报, 2021, 44(2): 96-99.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2021.02.004 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2021/V44/I2/96

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