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| Study on treatment mechanism of heart failure for astragali radix based on network pharmacology |
| DONG Pingping1,2, CEN Shuai1, LIU Zihan3, WANG Yuqi1, DAI Long3, WANG Shaoping1*, ZHANG Jiayu1* |
1 School of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, P.R.China;
2 Shandong University of Traditional Chinese Medicine, Jinan 250300, Shandong, P.R.China;
3 School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 102488, P.R.China |
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Abstract Objective To study the mechanism of astragali radix against heart failure based on network pharmacology.Methods The potential target of astragali radix against heart failure and signal pathways were predicted by active ingredient screening and target prediction technology, combined with bioinformatics. Finally, we explored the molecular mechanism of astragali radix in the treatment of heart failure.Results Twenty corresponding chemical constituents in astragali radix were screened through the TCMSP data, and 121 targets of these components were found using target prediction technology. Meanwhile, 10 962 known genes related to the occurrence and development of heart failure were retrieved from the gene databases. Eight key targets were selected by string database screening and network topology analysis in Cytoscape software. GO enrichment analysis showed that astragali radix played an important role in anti-heart failure by participating in 10 key signal pathways such as PI3K/AKT, p38MAPK, and MAPK/NF-κB, which were related to 10 biological functions including Cellular energy metabolism response, changes in blood vessel environment, hormone activity, nerve activity and receptor function.Conclusion As a traditional Chinese medicine, the effect of astragali radix against heart failure has the characteristics of multi-component, multi-target and mutual synergy.
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Received: 23 April 2020
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