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| Clinical observation of method of invigorating spleen and regulating liver combined with metformin in the treatmentof 72 cases of type 2 diabetes mellitus with non-alcoholic fatty liver due to liver depression and spleen deficiency |
| NI Linlin1, WANG Yuling2, WEI Youhua2, ZHOU Honglei1*, LI Haorui1 |
1 Shandong University of Traditional Chinese Medicine,Jinan 250355,Shandong,P.R.China;
2 Linyi Traditional Chinese Medicine Hospital,Linyi 276002,Shangdong |
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Abstract Objective To investigate the clinical effect of Tangyiping combined with metformin on type 2 diabetes mellitus with non-alcoholic fatty liver disease.Methods Seventy-two patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease were randomly divided into the treatment group and the control group,with 36 patients in each group.The treatment group was given oral administration of Tangyiping combined with metformin,while the control group was given oral administration of metformin tablets for a course of 3 months.After the treatment,TCM syndrome score,blood lipid,blood glucose level and li-ver function were compared between the two groups.Results After 12 weeks of treatment,TCM syndrome,2 h PG,TC,HbAlc,and TG of the experiment group were significantly lower than those of the control group (P<0.05);the improvement of fatty liver under B ultrasound was better than that of the control group (P<0.05),and HDL-C was significantly higher than that of the control group (P<0.05).Conclusion Tangyiping combined with metformin can improve TCM syndromes in patients with type 2 diabetes mellitus with liver depression and spleen deficiency combined with non-alcoholic fatty liver disease,reduce blood glucose and lipids,and improve liver injury and steatosis,so the effect is superior to that of metformin alone.
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Received: 28 February 2020
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