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| Synthesis and anti-inflammatory activity of resveratrol derivatives |
| KUANG Hongtao, WEN Shouhui, CAO Jiankang, XU Mengtong, AN Qi, MOU Xiaofeng*, ZHAO Feng* |
| Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Ministry of Educationof Molecular Pharmacology and Drug Evaluation, Yantai University, Yantai 264005, Shandong, P.R.China |
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Abstract Objective To obtain better drug lead compounds with anti-inflammatory activity from derivatives of natural product resveratrol. Methods Resveratrol was used as a lead compound for structural modification and 6 derivatives were designed and synthesized, including one methylation product, four esterification products and one amide analogue.The structures of all derivatives were characterized by 1H-NMR, and MS spectra. The inhibition on NO production of resveratrol derivatives in LPS-stimulated RAW 264.7 cells were tested by Griess method. Results The results indicated that amide derivative 6 possessed some application potential with good anti-inflammatory activities and no cytotoxity. Conclusion Research on the potential anti-inflammatory activity of resveratrol derivatives can provide a material basis for the research of new anti-inflammatory drug lead compounds.
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Received: 28 June 2019
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