PI3K/AKT/mTOR信号通路调控Th17细胞的研究进展

doi:10.19739/j.cnki.issn1001-9510.2020.03.017

Abstract
Figure/Table
References
Related Citation (2)

Download: PDF (702 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract CD4⁺ T cells are a kind of immune cells that play an important role in the immune response, which can be differentiated into Th1, Th2, Th17, Treg and other cell subsets after being activated. Th17 cells are new subtype of CD4⁺ effector T cells and play important roles in host defense against various pathogens and inflammatory pathogenesis. PI3K/AKT/mTOR signaling pathway can regulate cell metabolism, proliferation, differentiation, survival and other life processes, meanwhile, participate in the occurrence of tumors and autoimmune diseases. This review concentrated on the research progress in the regulation of the PI3K/AKT/mTOR signaling pathway on Th17 cells.

Key words： PI3K/AKT/mTOR signaling pathway Th17 cells IL- 17

Received: 20 December 2019

PACS:

R34

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Qian
	MA Lei
	XUE Haibo

Cite this article:

ZHANG Qian,MA Lei,XUE Haibo. Advances on the relationship between PI3K/AKT/mTOR signaling pathway and Th17 cells[J]. 滨州医学院学报, 2020, 43(3): 225-228.

URL:

http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2020.03.017 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2020/V43/I3/225

[1] KREBS C F,PANZER U.Plasticity and heterogeneity of Th17 in immune-mediated kidney diseases[J].J Autoimmun,2018,87:61-68.
[2] SCHORER M,KUCHROO V K,JOLLER N.Role of Co-stimulatory Molecules in T Helper Cell Differentiation[J].Adv Exp Med Biol,2019,1189:153-177.
[3] HARRINGTON L E,HATTON R D,MANGAN P R,et al.Interleukin 17-producing CD4⁺ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages[J].Nat Immunol,2005,6(11):1123-1132.
[4] LEE G R .The Balance of Th17 versus Treg Cells in Autoimmunity[J].Int J Mol Sci,2018,19(3):1-14.
[5] LI M,ZHAO Y,QI D,et al.Tangeretin attenuates lipopolysaccharide-induced acute lung injury through Notch signaling pathway via suppressing Th17?cell response in mice[J].Microb Pathog,2019,138:103826.
[6] ABDEL-MONEIM A,BAKERY H H.The potential pathogenic role of IL-17/Th17 cells in both type 1 and type 2 diabetes mellitus[J].Biomed Pharmacother,2018,101:287-292.
[7] LAWRENCE J,NHO R.The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis[J].Int J Mol Sci,2018,19(3):1-31.
[8] COSTA R L B,HAN H S,GRADISHAR W J.Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review[J].Breast Cancer Res Treat,2018,169(3):397-406.
[9] AZIZ A U R,FARID S, QIN K,et al.PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer[J].Biomolecules,2018,8(1).:1-14.
[10] HOLROYD A K,MICHIE A M.The role of mTOR-mediated signaling in the regulation of cellular migration[J].Immunol Lett,2018,196:74-79.
[11] SINGH S S,YAP W N,ARFUSO F,et al.Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?[J].World J Gastroenterol,2015,21(43):12261-12273.
[12] KUREBAYASHI Y,NAGAI S,IKEJIRI A,et al.PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ[J].Cell Rep,2012,1(4):360-373.
[13] NAGAI S,KUREBAYASHI Y,KOYASU S.Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation[J].Ann N Y Acad Sci,2013,1280:30-34.
[14] REN W,YIN J,DUAN J,et al.mTORC1 signaling and IL-17 expression: Defining pathways and possible therapeutic targets[J].Eur J Immunol,2016,46(2):291-299.
[15] MA J,MENG Y,KWIATKOESKI D J,et al.Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade[J].J ClinInvest,2010,120(1):103-114.
[16] SALERO D.Intersection of mTOR and STAT signaling in immunity[J].Trends Immunol,2015,36(1):21-29.
[17] KIM H Y,JHUN J Y,CHO M L,et al.Interleukin-6 upregulates Th17 response via mTOR/STAT3 pathway in acute-on-chronic hepatitis B liver failure[J].J Gastroenterol,2014,49(8):1264-1273.
[18] SASAKI C Y, CHEN G, MUNK R, etal.p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice[J].Eur J Immunol,2016,46(1):212-222.
[19] CARNEVALLI L S, MASUDA K, FRIGERN F, et al. S6K1 plays a critical role in early adipocyte differentiation[J]. Dev Cell, 2010,18(5):763-774.
[20] LASLO P, SPOONER C J, WARMFLASH A, et al. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates[J].Cell,2006,126(4):755-766.
[21] ROST B, YACHDAY G. The Predict Protein server[J].Nucleic Acids Res,2004,32(Web Server issue):W321-6.
[22] LIU P, CHEN S, WANG M. The role of nuclear localization signal in parvovirus life cycle[J]. Virol J,2017,14(1):80.
[23] IVANOV II, MCKENZIE B S, ZHOU L, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells[J].Cell,2006,126(6):1121-1133.