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| Clinical study of the correlation between HBV-DNA quantification, liver hardness value and hepatitis B cirrhosis with esophageal and gastric varicose endoscopy for early rebleeding |
| LIU Puhui1,2, LIU Yipin3, XU Ning3, CAO Xiaoling3, LI Xia3, JIANG Weiwei3, MOU Shaojiao3 |
1 Binzhou Medical University, Yantai 264003, P.R.China;
2 Third Medical Departments, Yantai Infectious Disease Hospital;
3 Department of Gastroenterology, Yantai Affiliated Hospital of Binzhou Medical University |
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Abstract Objective To investigate the clinical value of HBV-DNA quantification and liver stiffness in patients with hepatitis B cirrhosis complicated with esophagogastric variceal bleeding (EVB) after endoscopic treatment.Methods Patients with EVB who underwent endoscopic treatment from August 2016 to July 2018 were divided into the bleeding group (27 cases) and the non-bleeding group (201 cases) according to whether early bleeding occurred after treatment.The risk factors that may lead to rebleeding after EVB were assigned,and then Logstic regression analysis was performed to explore the risk factors of rebleeding after EVB.The correlation between HBV-DNA quantification,liver stiffness and prediction of rebleeding after endoscopic therapy was observed by describing the subject work curve (ROC). The specificity and sensitivity of the combined detection were calculated and the value of the combined detection was observed.Results (1)Among 228 EVB patients in this study,27 cases had early rebleeding after EVB.The early rebleeding rate after EVB endoscopy was 11.84%.(2)The HBV-DNA content and liver stiffness of patients with early rebleeding were significantly higher than those of patients without bleeding (P＜0.01).(3) Logistic regression analysis showed that HBV-DNA, liver stiffness,fasting blood glucose and the number of varices were risk factors for early rebleeding after EVB.(4)ROC curve showed that HBV-DNA content and liver stiffness could significantly improve the sensitivity and specificity of predicting rebleeding after EVB.Conclusion HBV DNA quantification and liver stiffness were significantly increased in patients with rebleeding after EVB.HBV DNA quantification and liver stiffness could be used to evaluate the risk of rebleeding after EVB.
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Received: 15 September 2018
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