主动灌注与分流栓在猪急性心肌缺血模型中心肌保护作用比较

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Abstract Objective To establish the porcine myocardial ischemia model, compare and estimate the protective effects of active perfusion and shunt perfusion on ischemic myocardial.Methods The acute myocardial ischemia was induced by suturing left anterior descending coronary artery at the proximal in 24 anesthetized,open-chest pigs. Thirty pigs were randomly divided into five groups:natural control group (N),shunt-55%coronary artery stenosis group (A1),shunt-75%coronary artery stenosis group (A2),active perfusion -55%coronary artery stenosis group (B1),and active perfusion -75% coronary artery stenosis group(B2).Aortic pressure(P₀),left anterior descending coronary pressure(P1), and the effective coronary artery pressure ratio (P₀/P₁) were measured 30mins after myocardial ischemia.The expression levels of TNF-α,cTnI,Mb,CK-MB,IL-6,and IL-10 were observed with Elisa,respectively.Results After operation, compared with those in the control group, left anterior descending coronary pressure(P₁),and the effective coronary artery pressure ratio (P₀/P₁) in other groups significantly decreased (P＜0.01) and TNF-α,cTnI,Mb,CK-MB,IL-6, and IL-10 in other groups significantly increased (P＜0.01).On the other hand, compared with those in group A,P₁ and P₁/P₀ in group B significantly increased (P＜0.01),and TNF-α,cTnI,Mb,CK-MB,IL-6,and IL-10 in group B significantly decreased (P＜0.01),showing that the degree of myocardial ischemia in B group was lower than that in group A.Conclusion Compared with shunt perfusion,active perfusion appears to have a more protective effect on ischemic myocardial.

Key words： acute myocardial ischemia animal model active perfusion shunt perfusion

Received: 15 March 2017

PACS:

R542.2

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	Articles by authors
	FENG Zanxiang
	HOU Fang
	LIU Baohui
	LI Wei
	WANG Feng
	QIAN Zhaoyang
	WANG Yujiu

Cite this article:

FENG Zanxiang,HOU Fang,LIU Baohui, et al. Comparison of protective effects of active perfusion and shunt perfusion on ischemic myocardial[J]. 滨州医学院学报, 2017, 40(4): 244-248.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/ OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2017/V40/I4/244

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