支气管肺泡灌洗阿米卡星治疗支气管扩张感染的临床疗效及对炎症因子的影响

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Abstract Objective To analyze the therapeutic effect of bronchoscopic injection of Amikacin on bronchiectasis and its influence on inflammatory factors.Methods A total of 72 patients with bronchiectasis were selected,they were randomly divided into control group and observation group,two groups were given routine medical treatment.The control group was intravenous injected with Amikacin and bronchoalveolar lavage with physiological saline,and the observation group was given Amikacin by bronchoscope, the clinical effect was synthetically analyzed.Results The total effective rate of the observation group (97.22%) was higher than that of the control group (83.33%);the symptoms disappeared and antibiotic application time was shorter than that in the control group,and the difference was statistically significant (P＜0.05);CRP,MMP-9 and IL-6 inflammatory factors after treatment were significantly lower in the observation group than that in the control group,P＜0.05.Study showed that 25 cases were markedly effective,10 cases effective,1 cases ineffective,the total effective rate was 97.22%,16 cases of control group were markedly effective,14 cases effective,6 cases ineffective, the total effective rate was 83.33%,there was significant difference between groups (χ²=3.9560,P＜0.05).Conclusion Bronchoscopic injection of Amikacin can significantly improve the bronchiectasis symptoms and inflammatory factors and improve the curative effect.

Key words： Bronchiectasis bronchoscopic Amikacin inflammatory factor

Received: 18 October 2017

PACS:

R562.2+2

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	Articles by authors
	ZHANG Xueping
	MA Xiaofen
	ZHAO Na
	WANG Meng
	ZHAI Yunqing

Cite this article:

ZHANG Xueping,MA Xiaofen,ZHAO Na, et al. Clinical efficacy of bronchoscopic injection of Amikacin in the treatment of bronchiectasis and its influence on inflammatory factors[J]. 滨州医学院学报, 2018, 41(2): 116-118.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/ OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2018/V41/I2/116

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