神经肌肉电刺激慢性阻塞性肺疾病患者股四头肌的临床研究

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Abstract Objective To explore the effects of neuromuscular electrical stimulation (NMES) of quadriceps femoris in patients with chronic obstructive pulmonary disease (COPD) with respect to exercise capacity, lung function, quadriceps shape, and inflammatory cytokines.Methods All the COPD patients were recruited from Binzhou community and randomly assigned to one of the two groups receiving NMES (the intervention group), and sham treatment (the control group) from November 2016 to December 2017. The above indexes were evaluated after 6 weeks.Exercise capacity was assessed by 6 minute walking distance (6MWD) and lung function was evaluated by FEV1 (forced expiratory volume in one second) and FVC (forced vital capacity).Rectus femoris cross-sectional area (RFCSA) and thickness (RFT) were measured by ultrasound. Inflammatory cytokines including tumor necrosis factor-α (TNF-α),C-reactive protein (CRP),and interleukin-8 (IL-8) were detected by enzyme-linked immunosorbent assay.Results After 6 weeks, the changes from baseline for RFCSA, RFT and 6MWD were significantly improved in the intervention group (all P＜0.05),and the difference was statistically significant (6MWD:P=0.03;RFCSA:P=0.04;RFT:P=0.04), while there was no significant difference in the control group (P＞0.05).There was no significant difference regarding to FEV1,FVC,and inflammatory cytokines including TNF-α, CRP and IL-8 between the two groups (all P＞0.05).Conclusion NMES can improve exercise capacity in COPD patients, which may be related to its increased RFCSA and RFT. NMES can be used as a potentially valuable rehabilitation therapy in patients with COPD.

Key words： chronic obstructive pulmonary disease neuromuscular electrical stimulation quadriceps exercise capacity

Received: 14 March 2018

PACS:

R563.3

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	Articles by authors
	YAN Junhong
	WANG Qian
	PAN Lei

Cite this article:

YAN Junhong,WANG Qian,PAN Lei. Clinical research of neuromuscular electrical stimulation of quadriceps femoris in patientswith chronic obstructive pulmonary disease[J]. 滨州医学院学报, 2018, 41(4): 262-265.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/ OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2018/V41/I4/262

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