|
|
|
| Determination of Fluconazole Ophthalmic Thermosensitive Gels by HPLC |
| ZHANG Qinggang1, WANG Fengqin2, XING Shuli2, ZHANG Jinjie2, SUN Yingdong2 |
1 Department of Pharmacy, Binzhou City Center Hospital, Binzhou 256000, P.R.China;
2 Department of Pharmacy, Binzhou Medical University Hospital |
|
|
|
|
Abstract Objective To establish an HPLC method for the content of Fluconazole Ophthalmic Thermosensitive Gels . Methods The method was performed on a C18. column, using mobile phase consisted of acetonitrile-0.063% ammonium formate soltuin(20∶80). The detection wavelength was 260 nm. Results Fluconazole in Fluconazole Ophthalmic Thermosensitive Gels can be effectively separated under this chromatographic condition. The linear ranges was 5.9~239.8 μg·mL-1(r=0.999 9) for assay. The mean recovery was 98.96%, RSD was 1.29%. Conclusion The method is accurate and stable for content determination of Fluconazole Ophthalmic Thermosensitive Gels .
|
|
Received: 26 February 2019
|
|
|
|
|
|
[1] 辛雨,郑颖,杨宏伟.氟康唑滴眼液治疗真菌性角膜炎的疗效观察[J].实用药物与临床, 2006, 9(3): 168-169.
[2] 吴尚国.真菌性角膜溃疡治疗的研究进展[J].中外医学研究,2017,15(17):160-161.
[3] 孙迎东,汪风芹,张金杰,等.氟康唑温敏型原位眼用凝胶基质处方研究[J].医药导报2018, 12(37): 1494-1497.
[4] 成新莲,王玉,刘秀莲,等.氟康唑眼凝胶治疗真菌性角膜溃疡的应用研究[J].滨州医学院学报, 2007, 30(5): 393-394.
[5] 国家药典委员会编.中华人民共和国药典(二部)[S]. 2015版,北京:中国医药科技出版社, 2015: 761.
[6] 周俊,唐蕾,刘锐锋,等.苯麻鼻用温敏凝胶的制备及质量控制[J].中国药师, 2016, 19(3): 596-598.
[7] 谢爱丽.氟康唑眼用剂型凝胶的制备及质量控制 [J].海峡药学,2012, 24(10): 26-27. |
| [1] |
YU Jingping, LIU Xiaona, SONG Jiaxuan, LI Liming, ZHANG Yongqing, ZHOU Jie, CHEN Caiyun, WANG Shaoping, LIN Ying. Comparison of ginsenosides from Panaxquinquefolium L. by two different extraction methods[J]. 滨州医学院学报, 2019, 42(4): 303-306. |
| [2] |
XIAO Lu, LI Shucui, LUAN Haiyun, ZHANG Shuping. Content determination of paeoniflorin in chaixiangshugan capsule by HPLC[J]. 滨州医学院学报, 2019, 42(1): 30-32. |
|
|
|
|
