海藻多糖对子宫内膜症大鼠炎症反应和氧化应激的影响

doi:10.19739/j.cnki.issn1001-9510.2021.02.003

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Abstract Objective To investigate the therapeutic effect of alga polysaccharide on endometriosis (EMS) and its effects on serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), malondialdehyde (MDA) and interleukin-6 (IL-6).Methods The rats were divided into five groups: the control group, the model group and three alga polysaccharide groups with different doses. Four weeks later, the rats were treated with alga polysaccharide at different doses. The pathological changes and serum levels of FSH, LH, MDA and IL-6 in rats with endometriosis were observed after 2 weeks of administration.Results The therapeutic effect of alga polysaccharide on endometriosis in rats was dose-dependent. The degree of atrophy and decrease of the glands and the serum levels of FSH, LH, MDA and IL-6 significantly decreased in alga polysaccharide groups compared with the model group.Conclusion Alga polysaccharide achieves the therapeutic effect of EMS in rats, and the underlying mechanisms may be through significantly inhibiting the proliferation of ectopic endometrium, accelerating the regression of inflammation, and reducing the levels of FSH, LH, MDA and IL-6 in serum.

Key words： alga polysaccharide endometriosis FSH MDA IL-6

Received: 11 September 2020

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R963

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	SHI Lin
	JIAO Xudong
	WANG Chengjun

Cite this article:

SHI Lin,JIAO Xudong,WANG Chengjun. Effects of alga polysaccharide on inflammatory response and oxidative stress in rats with endometriosis[J]. 滨州医学院学报, 2021, 44(2): 92-95.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2021.02.003 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2021/V44/I2/92

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