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Effect observation of gastrodia elata granule combined with nifedipine controlled-release tablet in the treatment of cervical hypertension |
LI Min1,2, WANG Huikai1, WANG Jinyan1, HE Qianqian1,2, GAO Junling1,2, GONG Kaikai2, MAN Yuqing2* |
1 Department of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, P.R.China; 2 Binzhou Medical University Hospital, Binzhou 256603, Shandong, P.R.China; 3 Binzhou Hospital of Traditional Chinese Medicine, Binzhou 256600, Shandong, P.R.China |
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Abstract Objective To observe the effect of gastrodia elata granule combined with nitradipine controlled-release tablet in patients with cervical hypertension.Methods One hundred and twenty patients with cervical hypertension were selected and randomly divided into 3 groups. In the experiment group, both gastrodia elata granule and nifedipine controlled-release tablets were taken orally, while in the first control group, nifedipine controlled-release tablets were taken orally, and in the second control group, gastrodia elata granule was taken orally. The treatment period was 4 weeks and the observation period was 8 weeks. Blood pressure, neck NDI score and neck NRS pain score before and after treatment were compared among the three groups after week 4 and week 8 respectively.Results Four weeks after the treatment, NRS pain score and NDI score in the neck of the three groups were all decreased, and the difference was not statistically significant. Eight weeks after the treatment, NRS pain score in the experiment group and the second control groups was lower than that in the first control group, P<0.05. Systolic blood pressure and diastolic blood pressure in the experiment group decreased 4 days after the treatment, and the antihypertensive effect of the experiment group and the first control group 8 weeks after the treatment was better than that of the second control group, P<0.05.Conclusion Gastrodia elata granule combined with nifedipine controlled-release tablets can significantly improve the clinical symptoms of neck and shoulder pain in patients with cervical hypertension. The antihypertensive effect is significant, and the side effects of western medicine are reduced. The patients′ satisfaction is high, so it is worthy of clinical promotion.
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Received: 26 April 2020
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