补充丙氨酰谷氨酰胺对老年食管癌患者同步放化疗治疗顺应性的影响

doi:10.19739/j.cnki.issn1001-9510.2020.04.014

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Abstract Objective To investigate the effect of alanyl-glutamine supplements in elderly patients with esophageal cancer on concurrent chemo-radiotherapy.Methods From November 2015 to November 2018,60 Elderly patients who were treated in our hospital with esophageal cancer on concurrent chemo-radiotherapy were recruited and randomly divided into the experimental group and the control group by random digits table.Both groups received routine nutritional support and dietary guidance,while only the experimental group received alanyl-glutamine supplements (20 g/d) on radiotherapy day.We compared blood indicators,changes in body weight,incidence of complications,completion rates of therapy and the T lymphocyte percentage of peri-pheral blood between the two groups.Results After chemoradiotherapy,albumin and hemoglobin of the control group decreased significantly,and the difference between the two groups was statistically significant,P<0.05.Compared with before treatment,the serum prealbumin level of the experimental group was higher than that of the control group,P<0.05.After chemoradiotherapy,serum transferrin of the control group decreased,P<0.05,and serum transferrin of the experimental group was higher than that of the control group,P<0.05.The incidence of radiation esophagitis and bone marrow suppression of the experimental group was significantly lower than that of the control group,P<0.05.There were no significant changes of body weight and incidence of radiation pneumonia before and after treatment in the two groups.The difference of immune indexes between the two groups was statistically significant,P<0.05.The completion rate of the treatment plan of the experimental group was higher than in the control group,P<0.05.Conclusion For patients undergoing concurrent chemoradiotherapy for esophageal cancer,supplementing alanyl glutamine is beneficial to improve nutritional status,reduce the incidence of complications,reduce the possibility of immune decline,and thus improve the therapeutic compliance of patients.

Key words： esophageal cancer chemoradiotherapy alanyl-glutamine injection

Received: 28 February 2020

PACS:

R735.1

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	CAO Liang
	ZHANG Shigeng
	LI Ruiqing

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CAO Liang,ZHANG Shigeng,LI Ruiqing. Study of alanyl-glutamine supplements on treatment compliance in elderly patientswith esophageal cancer on concurrent chemo-radiotherapy[J]. 滨州医学院学报, 2020, 43(4): 287-290.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2020.04.014 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2020/V43/I4/287

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