牙周炎孕妇龈沟液及血清中MMP-9和MMP-25检测对早产的预测价值

doi:10.19739/j.cnki.issn1001-9510.2020.02.012

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Abstract Objective To evaluate the predictive value of matrix metalloproteinases in preterm labor in pregnant women with periodontitis and examine the hypothesis that periodontitis was one of the sources of maternal inflammation in premature infants. Methods The samples of gingival crevicular fluid (GCF) and serum were collected from groups of 62 periodontitis mothers (PG) and 60 oral healthy mothers (HG). Levels of MMP-9 and MMP-25 were analyzed by enzyme-linked immunosorbent assay (ELISA). Results The gestational weeks of pregnant women in the PG were significantly fewer than those in the HG (P<0.05). MMP-9 and MMP-25 expression levels in GCF and serum were significantly higher in the PG than in the HG (P<0.05). Conclusion There was a tendency presenting the higher expression of MMP-9 and MMP-25 in CGF and serum, the shorter gestational period. Detection of the expression level of MMP-9 and MMP-25 in the body fluids of pregnant women with periodontitis in middle and late pregnancy can be used as a target to reduce the preterm rate.

Key words： periodontitis preterm gingival crevicular fluid serum MMP-9 MMP-25

Received: 28 June 2019

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	TIAN Tian
	WANG Aiqin

Cite this article:

TIAN Tian,WANG Aiqin. Detection effect of gingival crevicular fluid and serum matrix metalloproteinases in pregnant women with periodontitis on preterm birth prediction[J]. 滨州医学院学报, 2020, 43(2): 129-131.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2020.02.012 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2020/V43/I2/129

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