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| Expression of sclerostin in alveolar bone of experimental periodontitis in rats |
| LIU Yusan, CUI Caiyun, ZHANG Bin, LIU Min, LIU Rubing, RONG Li |
| Department of Stomatology, Binzhou Medical University Hospital, Binzhou 256603, Shandong, P.R.China |
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Abstract Objective To observe the expression and distribution of sclerostin in alveolar bone of experimental periodontitis in rats. Methods 16 SD rats of about 3 months old were randomly divided into 4 groups (1 blank control group and 3 experimental groups). The rats were sacrificed at 0, 3, 7, and 14 d, and the experimental tissue was taken. The expression and distribution of sclerostin were detected by immunohistochemistry. Results The model of rat periodontitis is made by ligating the teeth with silk, and the method is mature and reliable. Sclerostin was occasionally expressed in alveolar bone tissue of normal adult rats. On the third day, the number of sclerostin-positive bone cells increased exponentially, the 7 d group reached a peak, and the 14 d group began to decrease. Conclusion The cells participate in the pathogenesis and development of periodontitis through the synthesis of sclerostin; the destruction and reconstruction of alveolar bone, the expression shows a certain regularity with time.
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Received: 28 June 2019
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