石蒜碱衍生物LY-09对两种癌细胞增殖和迁移的影响

doi:10.19739/j.cnki.issn1001-9510.2019.06.011

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Abstract Objective To investigate the effects of Lycorine derivative LY-09 on proliferation and migration ofhuman A549 and MCF-7 cells, and preliminarily explore its possible mechanism. Methods With the doxorubicin and SAHA as the positive control, various concentrations (9,3,1, 0.3, 0.1, 0.03, 0.01, 0.003μM) of LY-09 was added in A549 and MCF-7 cells and then were cultured. MTT assay and the cell wound healing assay were applied to detect the proliferation and migration of cancer cells, respectively. In addition, the combination of LY-09 with doxorubicin or SAHA was also investigated. Results LY-09 could inhibit the proliferation and migration of A549 and MCF-7 cells (EC₅₀:0.081±0.024; 0.275±0.083 μM), with the concentration dependent property. The combination of LY-09 and SAHA could play a synergistic roleagainst cancer cells. Conclusion LY-09, a derivative of lycorine, can inhibit the proliferation and migration of A549 and MCF-7 cells and is expected to become a chemical precursor of anti-cancer drugs.

Key words： LY-09 anti-tumor cell proliferation cell migration drug combination

Received: 30 August 2019

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R285

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	XU Xiaoyi
	LIU Jingying
	LIU Hao

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XU Xiaoyi,LIU Jingying,LIU Hao. Effects of LY-09, a Lycorine derivative, on proliferation and migration of two cancer cells[J]. 滨州医学院学报, 2019, 42(6): 437-440.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2019.06.011 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2019/V42/I6/437

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