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| Dicer expression in visceral white adipose tissue of obese hypertension patients |
| LIU Hongxia, SHI Zhen |
| School of Basic Medical Sciences, Binzhou Medical University, Yantai 264003, P.R.China |
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Abstract Objective To investigate the expression of Dicer in visceral white adipose tissue of hypertension patients. Methods The visceral white adipose tissues from 314 patients who underwent elective abdominal surgery in our hospital were collected to detect the expression of Dicer by quantitative real-time PCR (qRT-PCR). And their clinical pathological data including age, height, weight and arterial blood pressure were collected for correlation analysis. Results Compared with the patients between 31 and 40 years old, the expression level of Dicer mRNA in visceral white adipose tissue of patients between 41 and 50 years old, between 51 and 60 years old, more than 60 years old increased, the difference was statistically significant (P<0.05); compared with the patients between 41 and 50 years old, the expression level of Dicer mRNA in visceral white adipose tissue of patients more than 60 years old increased, the difference was statistically significant (P<0.05); compared with the patients between 51 and 60 years old, the expression level of Dicer mRNA in visceral white adipose tissue of patients more than 60 years old increased, the difference was statistically significant (P<0.05). In the patients more than 60 years old, compared with the patients of normal blood pressure, the expression level of Dicer mRNA in visceral white adipose tissue of patients with hypertensive decreased, the difference was statistically significant (P<0.05). In the patients less than 60 years old, compared with the patients of normal blood pressure and weight, the expression level of Dicer mRNA in visceral white adipose tissue of patients with simple hypertension and obesity hypertension decreased, the difference was statistically significant (P<0.05); compared with the patients with simple hypertension, the expression level of Dicer mRNA in visceral white adipose tissue of patients with obesity hypertensive decreased, the difference was statistically significant (P<0.05). Conclusion The decreased expression of Dicer mRNA in the visceral white fat tissue was involved in occurrence and development of hypertension, especially obese hypertension.
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Received: 05 October 2019
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[1] 刘华玲, 章小英, 叶建平. 肥胖相关脂肪因子与高血压的关系[J]. 中华高血压杂志, 2019,27(1): 25-29.
[2] 吴妹珍, 蒋智渊, 钟国强. 腹型肥胖对糖尿病合并高血压患者心脏结构和功能的影响[J]. 广西医科大学学报, 2018, 35(5): 690-693.
[3] 曹清艳. 原发性高血压患者内脏脂肪分布的相关性研究[J]. 中西医结合心血管病杂志, 2016, 4(33): 137-138.
[4] Thomou T, Mori M A, Dreyfuss J M, et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues[J]. Nature. 2017,542(7642):450-455.
[5] 田晓玲, 王洪岩, 孙吉花, 等. 高血压脑出血手术患者医院感染现状及危险因素分析[J]. 滨州医学院学报, 2019,42(2): 81-83, 109.
[6] 陈步凤, 宋琼, 任瑞, 等. 社区综合护理干预对老年高血压患者疾病认知度和知晓率的影响[J]. 滨州医学院学报, 2018, 41(3): 194-196.
[7] Vegiopoulos A, Rohm M, Herzig S. Adipose tissue: between the extremes[J]. EMBO J,2017,36(14):1999-2017.
[8] 樊云秀,李建厂,孙维梅, 等. 微小RNA-132对白血病K562细胞增殖及凋亡的影响[J]. 滨州医学院学报, 2019, 42(1): 9-12.
[9] 郑婧.自发性高血压大鼠心肌组织microRNA-97a与TGF-β1蛋白表达的改变及意义[J].中国比较医学杂志, 2016, 26(11): 72-76.
[10] Thomou T, Mori M A, Dreyfuss J M, et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues[J]. Nature, 2017, 542(7642): 450-455. |
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