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| A randomized controlledtrial about the treatment of first-episode depression by agomelatine and escitalopram |
| LI Huijing1, CUI Minghu2 ZHANG Lanlan2, SUN Guizhi2, WU Xiaorui2, GE Xiangli1 |
1 School of Clinical Medicine, Binzhou Medical University, Yantai 264003, P.R.China;
2 Department of Psychology, Binzhou Medical University Hospital |
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Abstract Objective To explore the clinical efficacy and safety of agomelatine and escitalopram used for the treatment of first-episode depression. Methods Sixty patients with first-episode depression were randomly divided into the research group and control group, and each group had 30 patients. The control group was treated with escitalopram, and the research group was treated with agomelatine for 8 weeks. The Hamilton depression rating scale-17 (HAMD-17) and side effect scale (TESS) were used to evaluate the clinical efficacy and adverse reactions. The difference of clinical efficacy was compared according to HAMD-17 scores of two groups and the difference of adverse reactions was compared according to TESS scores of two groups. Results There was no statistically significant difference between the HAMD-17 scores of control group after treatment of 1 week and that before the treatment. The differences among the HAMD-17 scores of control group after treatment of 2, 4, 8 weeks and that before the treatment were significant. The differences were significant among the HAMD-17 scores of research group after treatment and that before the treatment. Conclusion The effect of escitalopram was better than that of agomelatine after treatment of 4 weeks. With the extension of time, the effect between escitalopram and agomelatine was similar after treatment of 8 weeks, but agomelatine had a rapid onset of effect, around 1 week, and escitalopram needs 2 weeks. Both drugs had fewer adverse reactions and higher safety.
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Received: 27 February 2019
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