自噬相关蛋白LC3II在非小细胞肺癌中的表达及其与放射治疗敏感性的相关性

doi:10.19739/j.cnki.issn1001-9510.2019.04.009

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Abstract Objective To study the expression of autophagy-related protein LC3II in non-small cell lung cancer (NSCLC, including lung adenocarcinoma and squamous cell carcinoma), and elucidate the influence and significance of autophagy expression on lung cancer radiotherapy curative effect. Methods Immunohistochemical method was used to detect the expression of LC3-II in 243 cases of non-small cell lung cancer based on retrospective study and 48 cases of normal lung tissue, and analyze the the relationship with expression of LC3II and clinicopathological factors. Dividing the patients into four groups according to the curative effect, to explore the relationship between the expression of LC3II and radiotherapy sensitivity. Results ① The positive expression of LC3II in the adenocarcinoma group and the squamous cell carcinoma group was lower than that in normal lung tissue.② High LC3II expression was found to be significantly correlated with tumor size, necrosis and TNM grade (P＜0.05) , but not with age, sex and pathological type. ③ Compared with all patients with positive expression of LC3II (52.7%), the positive rate of LC3II expression in CR group was the lowest (40.9%), whereas PD group was the highest (71.9%). Conclusion Autophagy-related protein LC3II was down-regulated in lung adenocarcinoma and squamous cell carcinoma, and associated with large size, necrosis and TNM grade, which may be related with the development of lung cancer. The high expression of autophagy is closely related to lung adenocarcinoma, squamous cell carcinoma and the radiation resistance, which would affect the efficacy of radiotherapy.

Key words： Lung cancer NSCLC Autophagy LC3II Radiotherapy radiotherapy

Received: 21 November 2018

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R734.2

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2019.04.009 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2019/V42/I4/267

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