神经精神性红斑狼疮危险因素的meta分析

doi:10.19739/j.cnki.issn1001-9510.2019.02.002

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Abstract Objective To investigate the risk factors for neuropsychiatric lupus erythematosus (NPSLE) and provide reference for the prevention and control of this disease.Methods Database including CNKI,Wanfang database,Weipu database, Pubmed, Cochrane were searched for studies on the risk factors of NPSLE (including central nervous lupus and lupus encephalopathy), and Stata 12.0 was used for the meta analysis.Results A total of 14 studies were included, with 1 028 cases in the case group(NPSLE group) and 2 101 cases in the control group(SLE group).A total of 26 possible risk factors were investigated in this study, among which were statistically significant as follows:white ball ratio (A/G decline or A/G inversion) (OR=2.491,95%CI=1.635~3.784),red blood cell decline(OR=2.086,95%CI=1.043~4.168),platelet decrease (OR=1.512,95%CI=1.037~2.203),erythrocyte sedimentation rate (ESR) (OR=2.415,95%CI=1.665~3.503),Alanine aminotransferase (ALT) increased (OR=3.536,95%CI=2.246~5.566),aspartate aminotransferase (AST) increased (OR=5.587, 95%CI=3.582~8.713), and urinary red blood cells increased (OR=2.906,95%CI=2.079~4.064),elevated creatinine (OR=4.6053,85%CI=1.872~11.326), elevated urea nitrogen or urea (OR=3.451,95%CI=2.372~5.022),anti-ribose The body P protein antibody was positive (OR=4.779,95%CI=3.053~7.483).Subgroup analysis of NPSLE risk factors showed that the above factors except for thrombocytopenia (OR=1.305,95%CI=0.808~2.108), butterfly erythema (OR=1.634,95%CI=1.110~2.406),blood vessels Inflammation (OR=1.810,95%CI=1.224~2.678),Anti Smith(Sm) antibody positive (OR=1.638,95%CI=1.202~2.232) are risk factors for NPSLE in Chinese population.Conclusion The occurrence of NPSLE is related to many factors, and there may be some differences between the risk factors of this disease in Chinese population and foreign populations. However, due to limited research, the Conclusion needs further proof.

Key words： neuropsychiatric lupus lupus encephalopathy central nervous lupus risk factors meta-analysis

Received: 10 October 2018

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R593.24

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	Articles by authors
	ZHOU Jun
	JIN Lairun
	TAO Mengjun
	YUAN Hui

Cite this article:

ZHOU Jun,JIN Lairun,TAO Mengjun, et al. A meta-analysis of risk factors for neuropsychiatric lupus erythematosus[J]. 滨州医学院学报, 2019, 42(2): 84-87.

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http://manu58.magtech.com.cn/Jwk_bzyxy/EN/10.19739/j.cnki.issn1001-9510.2019.02.002 OR http://manu58.magtech.com.cn/Jwk_bzyxy/EN/Y2019/V42/I2/84

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