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| Significance of HPV E6/E7 mRNA combined with thinprep cytologic test in cervical cancer screening |
| CHEN Wenqian, ZHANG Xiaotong, JIA Xiangqi, GUO Shanwei, NAN Fangfang |
| Department of Obstetrics and Gynecology,Binzhou Medical University Hospital,Binzhou 256603,P.R.China |
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Abstract Objective To explore the significance of the combined application of cervical E6/E7 mRNA and thinprep cytologic test (TCT) in cervical cancer screening.Methods 311 patients with cervical high risk HPV infected were chosen to carry on TCT,E6/E7 mRNA and histological examination,histological pathology Results as the gold standard.Results The sensitivity to high-level squamous intraepithelial lesion (HSIL) was 72.97%, the specificity was 90.08%,the positive predictive value (PPV) was 81.82%,and the negative predictive value (NPV) was 85.51%. The sensitivity of E6/E7 mRNA test in HSIL diagnosis was 69.64%,the specificity was 59.30%,and the PPV and NPV were 47.56% and 80.27%,respectively.The sensitivity of TCT to HSIL diagnosis was 56.25%,the specificity was 88.94%,and the PPV and NPV were 74.12% and 81.94%,respectively.Conclusion The sensitivity of E6/E7 mRNA was higher than that of TCT,and the specificity of TCT was higher than that of E6/E7 mRNA.The combination of E6/E7 mRNA and TCT significantly improved the sensitivity and specificity,and the PPV and NPV were more than 80%.Combined E6/E7 mRNA and TCT could improve the sensitivity and specificity of cervical cancer screening.
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Received: 20 June 2018
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